BENZOPHENONE-2
2,2',4,4'-Tetrahydroxybenzophenone
BENZOPHENONE-2 is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
2,2',4,4'-Tetrahydroxybenzophenone
- IUPAC name
- bis(2,4-dihydroxyphenyl)methanone
- Molecular formula
- C13H10O5
- Molecular weight
- 246.21 g/mol
- Exact mass
- 246.05282342 Da
- XLogP3
- 2.4
- Topological polar surface area
- 98.0 Ų
- Hydrogen-bond donors
- 4
- Hydrogen-bond acceptors
- 5
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 491 °C Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Yellow needles Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Light yellow powder Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.21 g/cu cm at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 198.8 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In water, 8,821 mg/L at 24.99 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In water, <1 g/100 mL at 30 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Very soluble in acetone, diethyl ether, ethanol Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Ethyl acetate 10, methanol 50, methyl ethyl ketone 22, toluene < 1 (all g/100 ml at 25 °C) Source: Hazardous Substances Data Bank (HSDB)
- Note: This chemical does not meet GHS hazard criteria for 3.3% (13 of 393) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H302 (96.4%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (33.8%): Causes skin irritation [Warning Skin corrosion/irritation]; H317 (32.1%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H319 (60.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (32.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H412 (26.5%): Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P272, P273, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P333+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 393 reports by companies from 13 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 13 of 393 reports by companies.; There are 12 notifications provided by 380 of 393 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: Hazardous Substances Data Bank (HSDB)
- GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: Hazardous Substances Data Bank (HSDB)
- Precautionary Statement Codes: P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Hazardous Substances Data Bank (HSDB)
- Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
- Toxicity Summary: IDENTIFICATION AND USE: Benzophenone-2 (BP2) is used as UV filter in a personal care products. Benzophenone-2 is commonly used in cosmetic products and food container plastics to filter out ultraviolet light. HUMAN STUDIES: Sensitization against benzophenone-2 has been reported. BP2, may disturb thyroid hormone homeostasis by inhibiting or inactivating thyroid peroxidase, effects that are even more pronounced in the absence of iodide. ANIMAL STUDIES: Benzophenone-2 was estrogenic in vitro and in the rat uterotropic assay. BP2 was shown to bind to the estrogen receptors. Benzophenone-2 was reported to be positive for mutagenicity using Salmonella typhimurium strains TA98, TA100, TA1535, and TA1537 with metabolic activation. An in vitro cytogenic assay was used to evaluate the ability of Benzophenone-2 to induce sister chromatid exchange (SCE) and chromosome aberrations (CA) in L5178Y mouse lymphoma cells. Benzophenone-2 does not directly induce significant SCE or CA increases but does, under metabolic activation, induce these changes. Benzophenone-2 induced an increase in mutations at the TK locus in L5178Y mouse lymphoma cells only for highly toxic doses with or without metabolic a Source: Hazardous Substances Data Bank (HSDB)
- Environmental Bioconcentration: An average BCF of 1.9 was calculated in fish for benzophenone-2, using fathead minnows (Pimephales promelas) which were exposed over 15-day period to 0.01-3.1 ug/g body weight(1). According to a classification scheme(2), this BCF suggests that bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 3200(SRC), determined from a structure estimation method(2), indicates that benzophenone-2 is expected to have slight mobility in soil(SRC). The estimated pKa1 and pKa2 values of benzophenone-2 are 7.1 and 7.9, respectively(3), indicating that this compound will exist partially in the anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Volatilization of the neutral species of benzophenone-2 from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.6X10-16 atm-cu m/mole(SRC), using a fragment constant estimation method(5). Benzophenone-2 is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 1.6X10-11 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). Biodegradation data in soil were not available(SRC, 2017) Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 3200(SRC), determined from a structure estimation method(2), indicates that benzophenone-2 is expected to adsorb to suspended solids and sediment(SRC). Volatilization of teh neutral species from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 3.6X10-16 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). The estimated pKa1 and pKa2 values of benzophenone-2 are 7.1 and 7.9, respectively(5) indicate benzophenone-2 will exist partially in the anion form at pH values of 5 to 9 and, therefore, volatilization from water surfaces is not expected to be an important fate process(SRC). According to a classification scheme(6), a BCF of 1.9(7) suggests that bioconcentration in aquatic organisms is low(SRC). Biodegradation data in water were not available(SRC, 2017). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), benzophenone-2, which has an estimated vapor pressure of 1.6X10-11 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely in the particulate phase in the ambient atmosphere. Particulate-phase benzophenone-2 may be removed from the air by wet and dry deposition(SRC). Benzophenone-2 absorbs UV light at wavelengths approximately 350 nm(3) and, therefore, may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Cosmetic Ingredient Review Link: CIR ingredient: Benzophenone-2 Source: Cosmetic Ingredient Review (CIR)
- Uses: Additives such as benzophenone-2 are commonly used in cosmetic products and food container plastics to filter out ultraviolet light... Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for BENZOPHENONE-2
INCI name
BENZOPHENONE-2
Description
2,2',4,4'-Tetrahydroxybenzophenone
Record provenance
- Inventory reference
- 74472
- Imported identity
- BENZOPHENONE-2
- Source update
- 15/10/2010
Annex records for BENZOPHENONE-2
Key data
- FRAGRANCE
- Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.
- UV ABSORBER
- Protecting the cosmetic product from the effects of UV-light.
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
How BENZOPHENONE-2 appears in the CosIng inventory
The CosIng inventory lists BENZOPHENONE-2 as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
BENZOPHENONE-2 is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
Source note for BENZOPHENONE-2
This page reproduces the CosIng inventory entry for BENZOPHENONE-2 from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research BENZOPHENONE-2 and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
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