Is TETRANDRINE safe to use in EU cosmetics?

TETRANDRINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 518-34-3?

CAS 518-34-3 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains TETRANDRINE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 6024815/10/2010

TETRANDRINE

Berbaman, 6,6',7,12-Tetramethoxy-2,2'-(Dimethyl-,(1beta)-

TETRANDRINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 518-34-3

CAS 518-34-3PubChem CID 73078

Tetrandrine

(+)-Tetrandrine is a bisbenzylisoquinoline alkaloid and a member of isoquinolines. — ChEBI

IUPAC name: (1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,31-dodecaene

Molecular formula: C38H42N2O6
Molecular weight: 622.7 g/mol
Exact mass: 622.30428706 Da
XLogP3: 6.4
Topological polar surface area: 61.9 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 8
Covalent units: 1
Defined stereocentres: 2

Also known as

D-Tetrandrine(+)-TetrandrineTetrandrinFanchinineSinomenine A(S,S)-TetrandrinehanjisongNSC-77037

16 more reported names

29EX23D5AJTETRANDRINE, D-TETRANDRINE, (+)-(1beta)-6,6',7,12-Tetramethoxy-2,2'-dimethylberbamanRefChem:932847tetrandrine, (1'beta)-tetrandrine dihydrochloride, (1beta)-6,6',7,12-tetramethoxy-2,2'-dimethyl-(1beta)-berbamanBerbaman, 6, 6',7,12-trtramethoxy-2,2'-dimethyl-, (1beta)-(PM)-683-095-7DL-Tetrandine(S,S)-(+)-TetrandrineNSC 77037S,S-(+)-Tetrandrine(+-)-TetrandineHanfangchin A

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:49
ChEMBL:CHEMBL176045
EPA DTXSID:DTXSID10178062
EPA DTXSID:DTXSID70881383
PubMed:38352826
PubMed:32930523
PubMed:31602212
PubMed:25722412
PubMed:2448307
PubMed:1331975

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TETRANDRINE

INCI name

TETRANDRINE

Description

Berbaman, 6,6',7,12-Tetramethoxy-2,2'-(Dimethyl-,(1beta)-

Record provenance

Inventory reference: 60248
Imported identity: TETRANDRINE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for TETRANDRINE

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Key data

CAS

518-34-3

—

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28595 · TETRANDRINE

Ingredients with overlapping formulation functions

TETRAMETHYL HEXAPHENYL TETRASILOXANESKIN CONDITIONING

TETRAMETHYL PYRAZOLYLPYRIMIDINE HCLSKIN CONDITIONING

TETRAMETHYL TETRAPHENYL TRISILOXANESKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

TETRAMETHYLCHROMANOL GLUCOSIDEANTIOXIDANT, HUMECTANT, SKIN CONDITIONING

TETRAPEPTIDE-1SKIN CONDITIONING

TETRAPEPTIDE-10SKIN CONDITIONING

TETRAPEPTIDE-11SKIN CONDITIONING

TETRAPEPTIDE-12SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TETRANDRINE appears in the CosIng inventory

The CosIng inventory lists TETRANDRINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TETRANDRINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TETRANDRINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TETRANDRINE carries the following function designation(s):

SKIN CONDITIONING

CAS 518-34-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TETRANDRINE

This page reproduces the CosIng inventory entry for TETRANDRINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TETRANDRINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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