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InventoryRef 5987915/10/2010

TRIPHENYL PHOSPHATE

Phosphoric acid, triphenyl ester

TRIPHENYL PHOSPHATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 115-86-6
CAS 115-86-6PubChem CID 8289

Triphenyl Phosphate

Triphenyl phosphate is an aryl phosphate resulting from the formal condensation of phosphoric acid with 3 mol eq. of phenol. It has a role as a plasticiser and a flame retardant. It is functionally related to a phenol. — ChEBI

IUPAC name
triphenyl phosphate
Molecular formula
C18H15O4P
Molecular weight
326.3 g/mol
Exact mass
326.07079595 Da
XLogP3
4.6
Topological polar surface area
44.8 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

TriphenylphosphatePhosphoric acid, triphenyl esterDisflamoll TPCelluflex TPPPhosflex TPPTriphenoxyphosphine oxideTrifenylfosfatPhenyl phosphate ((PhO)3PO)
16 more reported names
YZE19Z66EANSC-57868Triphenyl phosphoric acid esterCHEBI:35033204-112-2Triphenyl ester of phosphoric acidRefChem:6331NSC 57868C18H15O4PPhosphoric Acid Triphenyl EsterTrifenylfosfat [Czech]CAS-115-86-6TPHPTPPACCRIS 4888HSDB 2536
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8289

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • First Aid: (General first aid procedures); Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Note: This chemical does not meet GHS hazard criteria for 0.6% (9 of 1488) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H400 (83.4%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (86%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]; H411 (18.7%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1488 reports by companies from 25 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 9 of 1488 reports by companies.; There are 24 notifications provided by 1479 of 1488 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H303: May be harmful if swallowed [Warning Acute toxicity, oral]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation] Source: NITE-CMC
  • Precautionary Statement Codes: P264+P265, P301+P317, P305+P351+P338, and P337+P317 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: Hazardous Substances Data Bank (HSDB)
  • GHS Hazard Statements: H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: IDENTIFICATION AND USE: Triphenyl phosphate (TPP) is a solid. It is used as fire-retarding agent, and a plasticizer for cellulose acetate and nitrocellulose. Triphenyl phosphate also has been found as one component of lubricating oil and hydraulic fluids. HUMAN STUDIES: It causes a delayed peripheral neuritis involving motor neurons, resulting in a flaccid paralysis, particularly of the distal muscles. No sensory disturbances. Potential symptoms of overexposure are minor changes in blood enzymes. In workers engaged in the manufacture of TPP there was some inhibition of plasma cholinesterase but no correlation of this effect with degree of exposure or with minor gastrointestinal or neuromuscular symptoms. A case of TPP allergy from spectacle frames was reported. TPP increased both 17beta-estradiol (E2) and testosterone concentrations in human H295R cells in vitro. In addition, transcription of four major steroidogenic genes was up-regulated and that of two sulfotransferase genes was down-regulated. Increase of TPP concentration in house dust was associated with a 10% increase in prolactin and a 19% decrease in sperm concentration in exposed men. ANIMAL STUDIES: Topical application o Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: Bioconcentration factors (BCFs) of 180 to 280 have been measured in rainbow trout (Salmo gairdneri) exposed to Pydraul 50E (a hydraulic fluid containing 35% triphenyl phosphate) for 90 days in flowing water(1). A BCF range of 132 to 364 was observed for rainbow trout exposed to triphenyl phosphate in flowing water for 90 days(2). BCFs of 573 and 561 have been measured using static tests for radio-labelled triphenyl phosphate in rainbow trout and fathead minnows (Pimephales promelas), respectively(3). A bioaccumulation ratio (the rate of the initial uptake rate constant to the initial clearance rate constant) of 2,590 was determined for triphenyl phosphate in rainbow trout; however, this represents the worse-case estimate based on the total 14C content of whole fish after 24 hr exposure(4). A bioconcentration factor (BCF) for triphenyl phosphate of 250 was measured in killifish under static conditions and a BCF of 155 was measured in killifish in a flow through system(5). A BCF for triphenyl phosphate of 110 was observed in goldfish under static conditions(6). According to a classification scheme(7), this range of BCF values suggest that bioconcentration in aquatic organisms is high Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), a Koc range of 2,514 to 3,561(2) indicates that triphenyl phosphate is expected to have slight mobility in soil(SRC). Volatilization of triphenyl phosphate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.3X10-6 atm-cu m/mole(SRC), based upon its vapor pressure, 2.00X10-6 mm Hg(3), and water solubility, 1.9 mg/L(4). However, adsorption to soil is expected to attenuate volatilization(SRC). Triphenyl phosphate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Mineralization half-lives of 37 and 32 days under aerobic and anaerobic conditions, respectively, using a loamy sand(2) suggest that biodegradation may be an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), a Koc range of 2,514 to 3,561(2) indicates that triphenyl phosphate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.3X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 2.00X10-6 mm Hg(4), and water solubility, 1.9 mg/L(5). Estimated volatilization half-lives for a model river and model lake are 20 and 152 days, respectively. However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 400 days if adsorption is considered(6). According to a classification scheme(7), bioconcentration factors ranging from 132(8) to 573(9) suggest that bioconcentration in aquatic organisms is high(SRC). Biodegradation half-lives of 2-4 days in river die-away tests(10) suggest that biodegradation may be an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), triphenyl phosphate, which has a vapor pressure of 2.00X10-6 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase triphenyl phosphate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 12 hours(SRC), calculated from its rate constant of 1.1X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase triphenyl phosphate may be removed from the air by wet and dry deposition(SRC). Triphenyl phosphate does not absorb light at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Link: CIR ingredient: Triphenyl Phosphate Source: Cosmetic Ingredient Review (CIR)
  • Sources/Uses: Used as a plasticizer, fire-retardant, and substitute for camphor in celluloid; also used in lubricating oils and hydraulic fluids; [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Noncombustible substitute for camphor in celluloid; rendering acetylcellulose, nitrocellulose, airplane "dope", etc., stable and fireproof; impregnating roofing paper; plasticizer in lacquers and varnishes. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Fire-retarding agent, plasticizer for cellulose acetate and nitrocellulose. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: /Triphenyl phosphate/ has been used as a plasticizer in automobile upholstery, as a fireproofing agent, as a noncombustible substitute for camphor in celluloid, and for impregnating roofing paper. Triphenyl phosphate also has been found as one component of lubricating oil and hydraulic fluids. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: An early application was as a flame retardant for cellulose acetate safety film. It is also used in cellulose nitrate, various coatings, triacetate film and sheet, and rigid urethane foam. It has been used as a flame-retardant additive for engineering thermoplastics such as polyphenylene oxide-high impact polystyrene and ABS-polycarbonate blends. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Plastics -> Typical concentration range in plastic materials -> 2% Source: NORMAN Suspect List Exchange

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TRIPHENYL PHOSPHATE

INCI name

TRIPHENYL PHOSPHATE

Description

Phosphoric acid, triphenyl ester

Record provenance

Inventory reference
59879
Imported identity
TRIPHENYL PHOSPHATE
Source update
15/10/2010
European Commission CosIng source notes
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Key data

CAS
115-86-6
EC
204-112-2
Restriction
—
Function
PLASTICISER
Softening and making supple synthetic polymers that otherwise could not be easily deformed, spread or worked out.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#29421 · TRIPHENYL PHOSPHATE

Ingredients with overlapping formulation functions

TRIMETHYL PENTANYL DIISOBUTYRATEPLASTICISER
TRIMETHYLPENTANEDIYL DIBENZOATEPLASTICISER
TRIOLEYL CITRATEPLASTICISER, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT
TRIOLEYL PHOSPHATEPLASTICISER, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT
TRIPROPYLENE GLYCOL DIACRYLATEPLASTICISER
TRISTEARYL PHOSPHATEPLASTICISER, SURFACTANT - CLEANSING
XYLITYL COCOATEEMULSION STABILISING, HUMECTANT, PLASTICISER, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SUR…

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How TRIPHENYL PHOSPHATE appears in the CosIng inventory

The CosIng inventory lists TRIPHENYL PHOSPHATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TRIPHENYL PHOSPHATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TRIPHENYL PHOSPHATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TRIPHENYL PHOSPHATE carries the following function designation(s):

CAS 115-86-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for TRIPHENYL PHOSPHATE

This page reproduces the CosIng inventory entry for TRIPHENYL PHOSPHATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

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