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EU cosmetic ingredients, restrictions and safety
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Official EU label nameGlossary entry 29421

TRIPHENYL PHOSPHATE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

0 markets with evidence
Markets checked
13
Markets with evidence
0
Evidence gaps
13
Resolved identifiers
2

A missing local match is not permission, approval or proof of safety. It means no strong identity match was resolved in that indexed dataset.

Resolved substance identity

CAS:115-86-6
EC:204-112-2
Ingredient index records:
TRIPHENYL PHOSPHATE
Cosmetic functions: PLASTICISER

Phosphoric acid, triphenyl ester

Open full local profile
1 matched or reported name
TRIPHENYL PHOSPHATE

Regulatory evidence in all 13 markets

Open each matched record for its scope, concentration, conditions, warnings and official source version.

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MarketResultRecordsDatasetMeaning / next action
European Union
EU
No local match0
Complete annex dataset
Regulation (EC) 1223/2009 consolidated to 1 May 2026
No annex match only means that these five annexes did not return a match; CosIng identity data and other EU obligations still need review.
Great Britain
GB
No local match0
Complete consolidated annex dataset
GB retained Regulation 1223/2009 schedules, effective 15 August 2026
No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.
Canada
CA
No local match0
Complete Hotlist snapshot
Health Canada Cosmetic Ingredient Hotlist, 13 August 2025
The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.
New Zealand
NZ
No local match0
Complete schedules dataset
Cosmetic Products Group Standard schedules effective 1 January 2026
The searchable spreadsheet is an aid; the legal Group Standard and incorporated notices remain authoritative.
ASEAN
ASEAN
No local match0
Complete regional annex dataset
ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026
Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.
China
CN
No local match0
Complete prohibited catalogues plus official-source workflow
NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025
IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.
Japan
JP
No local match0
Complete Standards appendices dataset
MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot
The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.
South Korea
KR
No local match0
Complete current appendix dataset
MFDS Notice 2026-19, effective 18 March 2026
Korean source wording is canonical and other positive lists/notices may still apply to the formulation.
United States
US
No local match0
Complete enumerated federal ingredient rules
eCFR Title 21 issue date 27 August 2026
FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety.
Australia
AU
No local match0
Complete cosmetic-relevant Poisons Standard subset plus official workflow
Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026
An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.
Brazil
BR
No local match0
Complete prohibited dataset plus current restricted-list workflow
ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026
RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.
India
IN
No local match0
Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4
Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)
The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.
Saudi Arabia
SA
No local match0
Complete official list index
SFDA live prohibited/restricted lists, snapshot 30 August 2026
No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.
No market rows match this filter.

Chemical identity and properties

PubChem 2D chemical structure for CAS 115-86-6
CAS 115-86-6PubChem CID 8289

Triphenyl Phosphate

IUPAC name
triphenyl phosphate
Molecular formula
C18H15O4P
Molecular weight
326.3 g/mol
Exact mass
326.07079595 Da
XLogP3
4.6
Topological polar surface area
44.8 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
4
Covalent units
1
Defined stereocentres
0

Also known as

TriphenylphosphatePhosphoric acid, triphenyl esterDisflamoll TPCelluflex TPPPhosflex TPPTriphenoxyphosphine oxideTrifenylfosfatPhenyl phosphate ((PhO)3PO)
16 more reported names
YZE19Z66EANSC-57868Triphenyl phosphoric acid esterCHEBI:35033204-112-2Triphenyl ester of phosphoric acidRefChem:6331NSC 57868C18H15O4PPhosphoric Acid Triphenyl EsterTrifenylfosfat [Czech]CAS-115-86-6TPHPTPPACCRIS 4888HSDB 2536
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match8289

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknow Source: CAMEO Chemicals
  • First Aid: (General first aid procedures); Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Note: This chemical does not meet GHS hazard criteria for 0.6% (9 of 1488) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H400 (83.4%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (86%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]; H411 (18.7%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1488 reports by companies from 25 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 9 of 1488 reports by companies.; There are 24 notifications provided by 1479 of 1488 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: NITE-CMC
  • GHS Hazard Statements: H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P273, P391, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H303: May be harmful if swallowed [Warning Acute toxicity, oral]; H320: Causes eye irritation [Warning Serious eye damage/eye irritation] Source: NITE-CMC
  • Precautionary Statement Codes: P264+P265, P301+P317, P305+P351+P338, and P337+P317 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Warning Source: Hazardous Substances Data Bank (HSDB)
  • GHS Hazard Statements: H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
  • Toxicity Summary: IDENTIFICATION AND USE: Triphenyl phosphate (TPP) is a solid. It is used as fire-retarding agent, and a plasticizer for cellulose acetate and nitrocellulose. Triphenyl phosphate also has been found as one component of lubricating oil and hydraulic fluids. HUMAN STUDIES: It causes a delayed peripheral neuritis involving motor neurons, resulting in a flaccid paralysis, particularly of the distal muscles. No sensory disturbances. Potential symptoms of overexposure are minor changes in blood enzymes. In workers engaged in the manufacture of TPP there was some inhibition of plasma cholinesterase but no correlation of this effect with degree of exposure or with minor gastrointestinal or neuromuscular symptoms. A case of TPP allergy from spectacle frames was reported. TPP increased both 17beta-estradiol (E2) and testosterone concentrations in human H295R cells in vitro. In addition, transcription of four major steroidogenic genes was up-regulated and that of two sulfotransferase genes was down-regulated. Increase of TPP concentration in house dust was associated with a 10% increase in prolactin and a 19% decrease in sperm concentration in exposed men. ANIMAL STUDIES: Topical application o Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: Bioconcentration factors (BCFs) of 180 to 280 have been measured in rainbow trout (Salmo gairdneri) exposed to Pydraul 50E (a hydraulic fluid containing 35% triphenyl phosphate) for 90 days in flowing water(1). A BCF range of 132 to 364 was observed for rainbow trout exposed to triphenyl phosphate in flowing water for 90 days(2). BCFs of 573 and 561 have been measured using static tests for radio-labelled triphenyl phosphate in rainbow trout and fathead minnows (Pimephales promelas), respectively(3). A bioaccumulation ratio (the rate of the initial uptake rate constant to the initial clearance rate constant) of 2,590 was determined for triphenyl phosphate in rainbow trout; however, this represents the worse-case estimate based on the total 14C content of whole fish after 24 hr exposure(4). A bioconcentration factor (BCF) for triphenyl phosphate of 250 was measured in killifish under static conditions and a BCF of 155 was measured in killifish in a flow through system(5). A BCF for triphenyl phosphate of 110 was observed in goldfish under static conditions(6). According to a classification scheme(7), this range of BCF values suggest that bioconcentration in aquatic organisms is high Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), a Koc range of 2,514 to 3,561(2) indicates that triphenyl phosphate is expected to have slight mobility in soil(SRC). Volatilization of triphenyl phosphate from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.3X10-6 atm-cu m/mole(SRC), based upon its vapor pressure, 2.00X10-6 mm Hg(3), and water solubility, 1.9 mg/L(4). However, adsorption to soil is expected to attenuate volatilization(SRC). Triphenyl phosphate is not expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Mineralization half-lives of 37 and 32 days under aerobic and anaerobic conditions, respectively, using a loamy sand(2) suggest that biodegradation may be an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), a Koc range of 2,514 to 3,561(2) indicates that triphenyl phosphate is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.3X10-6 atm-cu m/mole(SRC), derived from its vapor pressure, 2.00X10-6 mm Hg(4), and water solubility, 1.9 mg/L(5). Estimated volatilization half-lives for a model river and model lake are 20 and 152 days, respectively. However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 400 days if adsorption is considered(6). According to a classification scheme(7), bioconcentration factors ranging from 132(8) to 573(9) suggest that bioconcentration in aquatic organisms is high(SRC). Biodegradation half-lives of 2-4 days in river die-away tests(10) suggest that biodegradation may be an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), triphenyl phosphate, which has a vapor pressure of 2.00X10-6 mm Hg at 25 °C(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase triphenyl phosphate is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 12 hours(SRC), calculated from its rate constant of 1.1X10-11 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Particulate-phase triphenyl phosphate may be removed from the air by wet and dry deposition(SRC). Triphenyl phosphate does not absorb light at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Cosmetic Ingredient Review Link: CIR ingredient: Triphenyl Phosphate Source: Cosmetic Ingredient Review (CIR)
  • Sources/Uses: Used as a plasticizer, fire-retardant, and substitute for camphor in celluloid; also used in lubricating oils and hydraulic fluids; [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Noncombustible substitute for camphor in celluloid; rendering acetylcellulose, nitrocellulose, airplane "dope", etc., stable and fireproof; impregnating roofing paper; plasticizer in lacquers and varnishes. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Fire-retarding agent, plasticizer for cellulose acetate and nitrocellulose. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: /Triphenyl phosphate/ has been used as a plasticizer in automobile upholstery, as a fireproofing agent, as a noncombustible substitute for camphor in celluloid, and for impregnating roofing paper. Triphenyl phosphate also has been found as one component of lubricating oil and hydraulic fluids. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: An early application was as a flame retardant for cellulose acetate safety film. It is also used in cellulose nitrate, various coatings, triacetate film and sheet, and rigid urethane foam. It has been used as a flame-retardant additive for engineering thermoplastics such as polyphenylene oxide-high impact polystyrene and ABS-polycarbonate blends. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Plastics -> Typical concentration range in plastic materials -> 2% Source: NORMAN Suspect List Exchange

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

These source-specific lookups can add hazard, toxicology, identity and assessment context. A link is a research route, not a claim that the source contains an exact record.

Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

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FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

Identity registry only; UNII availability does not imply FDA review or approval

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ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

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Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

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NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

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OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

Discovery gateway; each linked authority remains responsible for its data

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US EPA CompTox CTX APIs

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality

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2. Review restrictions

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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