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CAS 621-23-8 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 5928815/10/2010

PHLOROGLUCINOL TRIMETHYL ETHER

Benzene, 1,3,5-trimethoxy-

PHLOROGLUCINOL TRIMETHYL ETHER is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 621-23-8

CAS 621-23-8PubChem CID 69301

1,3,5-Trimethoxybenzene

1,3,5-trimethoxybenzene is a methoxybenzene carrying methoxy groups at positions 1, 3 and 5. It has been found to be a biomarker of flavonoid consumption in humans. It has a role as a biomarker and a human xenobiotic metabolite. — ChEBI

IUPAC name: 1,3,5-trimethoxybenzene

Molecular formula: C9H12O3
Molecular weight: 168.19 g/mol
Exact mass: 168.078644241 Da
XLogP3: 2.0
Topological polar surface area: 27.7 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

Phloroglucinol trimethyl ethersym-TrimethoxybenzeneBenzene, 1,3,5-trimethoxy-1,3,5-Trimethyoxybenzene00VJI3VG3DNSC-90060CHEBI:31038RefChem:412646

16 more reported names

210-673-4Phloroglucinol Impurity 271,3,5-Trimethoxybenzene (JAN)1,3,5-TRIMETHOXYBENZENE [JAN]CAS-621-23-8O,O,O-1,3,5-TrimethylresorcinolEINECS 210-673-4NSC 90060UNII-00VJI3VG3D1,3,5-Trimethoxy benzeneBRN 13079931,5-TrimethoxybenzeneSpectrum_0014041,5-Trimethyoxybenzene1,3,5-Methoxybenzene1,3,5-trimethoxybenzol

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:31038
ChEMBL:CHEMBL1605492
EPA DTXSID:DTXSID0045963
PubMed:23002789
PubMed:22707000
PubMed:22475263
PubMed:22200482
PubMed:22194838
PubMed:22065835
PubMed:21954326
PubMed:21902275
PubMed:21754811
PubMed:21696161
PubMed:21587929
PubMed:21587546

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PHLOROGLUCINOL TRIMETHYL ETHER

INCI name

PHLOROGLUCINOL TRIMETHYL ETHER

Description

Benzene, 1,3,5-trimethoxy-

Record provenance

Inventory reference: 59288
Imported identity: PHLOROGLUCINOL TRIMETHYL ETHER
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for PHLOROGLUCINOL TRIMETHYL ETHER

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Key data

CAS

621-23-8

210-673-4

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#20764 · PHLOROGLUCINOL TRIMETHYL ETHER

Ingredients with overlapping formulation functions

PHLOMIS KORAIENSIS ROOT EXTRACTSKIN CONDITIONING

PHLOMIS LYCHNITIS EXTRACTSKIN CONDITIONING

PHLORIDZINSKIN CONDITIONING

PHLORIDZINYL GLUCOSIDEANTIOXIDANT, SKIN CONDITIONING

PHLOX DRUMMONDII SEED EXTRACTHAIR CONDITIONING, NAIL CONDITIONING, SKIN CONDITIONING

PHOENIX DACTYLIFERA FRUIT JUICESKIN CONDITIONING

PHOENIX DACTYLIFERA FRUIT POWDERSKIN CONDITIONING

PHOENIX DACTYLIFERA SEEDSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PHLOROGLUCINOL TRIMETHYL ETHER appears in the CosIng inventory

The CosIng inventory lists PHLOROGLUCINOL TRIMETHYL ETHER as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PHLOROGLUCINOL TRIMETHYL ETHER is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PHLOROGLUCINOL TRIMETHYL ETHER is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PHLOROGLUCINOL TRIMETHYL ETHER carries the following function designation(s):

SKIN CONDITIONING

CAS 621-23-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for PHLOROGLUCINOL TRIMETHYL ETHER

This page reproduces the CosIng inventory entry for PHLOROGLUCINOL TRIMETHYL ETHER from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PHLOROGLUCINOL TRIMETHYL ETHER and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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