What does the restriction note for SPERMIDINE HCL mean?

The restriction field for SPERMIDINE HCL reads: II/411. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 334-50-9?

CAS 334-50-9 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains SPERMIDINE HCL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 5844715/11/2016

SPERMIDINE HCL

1,4-Butanediamine, N-(3-Aminopropyl)-, Trihydrochloride

SPERMIDINE HCL is linked to 1 EU annex record on this page. Inventory note: II/411.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 334-50-9

CAS 334-50-9PubChem CID 9539

Spermidine trihydrochloride

Spermidine trihydrochloride is an organic molecular entity. It has a role as an EC 1.14.13.39 (nitric oxide synthase) inhibitor. It is functionally related to a spermidine. — ChEBI

IUPAC name: N'-(3-aminopropyl)butane-1,4-diamine;trihydrochloride

Molecular formula: C7H22Cl3N3
Molecular weight: 254.6 g/mol
Exact mass: 253.087931 Da
Topological polar surface area: 64.1 Å²
Hydrogen-bond donors: 6
Hydrogen-bond acceptors: 3
Covalent units: 4
Defined stereocentres: 0

Also known as

Spermidine hydrochlorideSpermidine HClN-(3-Aminopropyl)-1,4-butanediamine trihydrochlorideEINECS 206-379-0NSC 5283991,4-BUTANEDIAMINE, N-(3-AMINOPROPYL)-, TRIHYDROCHLORIDE1O14BED3981,4-Butanediamine, N-(3-aminopropyl), hydrochloride

16 more reported names

4-Azoniaoctamethylenediammonium trichlorideNSC-528399SPERMIDINE TRIHYDROCHLORIDE [MI]1,4-Butanediamine, N1-(3-aminopropyl)-, hydrochloride (1:3)RefChem:888501SPERMIDINE HCL [INCI]4Azoniaoctamethylenediammonium trichlorideN(3Aminopropyl)1,4butanediamine trihydrochloride1,4Butanediamine, N(3aminopropyl), hydrochloride1,4Butanediamine, N(3aminopropyl), trihydrochloride1,4Butanediamine, N1(3aminopropyl), hydrochloride (1:3)N1-(3-Aminopropyl)butane-1,4-diamine trihydrochlorideSpermidine (trihydrochloride)(4-aminobutyl)(3-aminopropyl)amine trihydrochlorideSR-01000075461UNII-1O14BED398

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:233088
ChEMBL:CHEMBL1473196
EPA DTXSID:DTXSID0059825
PubMed:4055

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for SPERMIDINE HCL

INCI name

SPERMIDINE HCL

Description

1,4-Butanediamine, N-(3-Aminopropyl)-, Trihydrochloride

Record provenance

Inventory reference: 58447
Imported identity: SPERMIDINE HCL
Source update: 15/11/2016

European Commission CosIng source notes

Annex records for SPERMIDINE HCL

Annex II Restriction reference

Entry 411

Secondary alkyl- and alkanolamines and their salts

CAS: 111-42-2 / 110-97-4

EC: 203-868-0 / 203-820-9

Key data

CAS

334-50-9

206-379-0

Restriction

II/411

Function

HAIR CONDITIONING: Enhancing the appearance and feel of hair. Leaving the hair easy to comb, supple, soft and shiny and/or imparting volume, lightness, gloss, texture, etc.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#27400 · SPERMIDINE HCl

Ingredients with overlapping formulation functions

SPATHOLOBUS SUBERECTUS EXTRACTANTIMICROBIAL, HAIR CONDITIONING, HUMECTANT, SKIN PROTECTING

SPENT GRAIN EXTRACTANTIOXIDANT; HAIR CONDITIONING; SKIN PROTECTING; SKIN CONDITIONING - HUMECTANT

SPENT GRAIN POWDERANTIOXIDANT; BULKING; HAIR CONDITIONING; SKIN PROTECTING

SPERMIDINEANTIOXIDANT, HAIR CONDITIONING

SPHINGANINEHAIR CONDITIONING, SKIN CONDITIONING

SPILANTHES ACMELLA FLOWER EXTRACTHAIR CONDITIONING, SKIN CONDITIONING

SPINOCHROMESANTIOXIDANT, HAIR CONDITIONING

SPIRAEA SALICIFOLIA EXTRACTHAIR CONDITIONING; HUMECTANT; SKIN PROTECTING; SKIN CONDITIONING - HUMECTANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How SPERMIDINE HCL appears in the CosIng inventory

The CosIng inventory lists SPERMIDINE HCL as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SPERMIDINE HCL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SPERMIDINE HCL appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for SPERMIDINE HCL reads: "II/411". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, SPERMIDINE HCL carries the following function designation(s):

HAIR CONDITIONING

CAS 334-50-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for SPERMIDINE HCL

This page combines the CosIng inventory entry for SPERMIDINE HCL with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research SPERMIDINE HCL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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