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CAS 674-26-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 5819515/10/2010

MEVALONOLACTONE

2H-Pyran-2-one, tetrahydro-4-hydroxy-4-methyl-, (+/-)-

MEVALONOLACTONE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 674-26-0

CAS 674-26-0PubChem CID 10428

(+-)-Mevalonolactone

4-hydroxy-4-methyloxan-2-one is a member of the class of 2-pyranones that is tetrahydro-2H-pyran-2-one substituted by a methyl and hydroxy group at position 4. It has a role as a plant metabolite. It is a tertiary alcohol and a member of 2-pyranones. — ChEBI

IUPAC name: 4-hydroxy-4-methyloxan-2-one

Molecular formula: C6H10O3
Molecular weight: 130.14 g/mol
Exact mass: 130.062994177 Da
XLogP3: -0.3
Topological polar surface area: 46.5 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

DL-Mevalonic acid lactone1RJ06DC41BRefChem:818792Mevalonolactone, (+-)-DL-Mevalonolactone4-Hydroxy-4-methyltetrahydro-2H-pyran-2-oneD,L-Mevalonic Acid LactoneMevalolactone

16 more reported names

(+/-)-Mevalonolactone4-hydroxy-4-methyl-tetrahydropyran-2-oneMevalonolactone, (+/-)-MEVALONOLACTONE, DL-Mevalonic lactoneMevalonic acid .delta.-lactone503-48-0HMS2097E22NSC-90804AS-65830tetrahydro-4-hydroxy-4-Methylpyran-2-onebeta-Hydroxy-beta-methyl-delta-valerolactoneCS-0030738DL-Mevalolactone2H-Pyran-2-one, tetrahydro-4-hydroxy-4-methyl-.beta.-Hydroxy-.beta.-methyl-.delta.-valerolactone

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:95115
ChEMBL:CHEMBL4758470
EPA DTXSID:DTXSID00964572
PubMed:22796672
PubMed:22276116
PubMed:22073170
PubMed:22073134
PubMed:21990128
PubMed:21620829
PubMed:21540247
PubMed:21355014
PubMed:20964856
PubMed:20883752
PubMed:20396700
PubMed:20233097

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for MEVALONOLACTONE

INCI name

MEVALONOLACTONE

Description

2H-Pyran-2-one, tetrahydro-4-hydroxy-4-methyl-, (+/-)-

Record provenance

Inventory reference: 58195
Imported identity: MEVALONOLACTONE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for MEVALONOLACTONE

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Key data

CAS

674-26-0

211-615-0

Restriction

—

Function

HUMECTANT: Retaining and/or preserving the moisture in a product during use.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#16693 · MEVALONOLACTONE

Ingredients with overlapping formulation functions

METHYLINOSITOLHUMECTANT, SKIN CONDITIONING

METHYLSILANOL PCAHUMECTANT, SKIN CONDITIONING

METSCHNIKOWIA HENANENSIS EXTRACTHUMECTANT, SKIN CONDITIONING

METSCHNIKOWIA VITICOLA EXTRACTHUMECTANT, SKIN CONDITIONING

MICROBACTERIUM/PANAX GINSENG ROOT FERMENT FILTRATEHUMECTANT, SKIN CONDITIONING

MINOXIDIL HYALURONAMIDEHUMECTANT

MOMORDICA CHARANTIA STEM SAPHUMECTANT, SKIN CONDITIONING

MOMORDICA GROSVENORII FRUIT JUICEHUMECTANT, SOLVENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How MEVALONOLACTONE appears in the CosIng inventory

The CosIng inventory lists MEVALONOLACTONE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

MEVALONOLACTONE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

MEVALONOLACTONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, MEVALONOLACTONE carries the following function designation(s):

HUMECTANT

CAS 674-26-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for MEVALONOLACTONE

This page reproduces the CosIng inventory entry for MEVALONOLACTONE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research MEVALONOLACTONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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