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CAS 2457-80-9 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 5819415/10/2010

METHYLTHIOADENOSINE

Adenosine thiomethylpentose

METHYLTHIOADENOSINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 2457-80-9

CAS 2457-80-9PubChem CID 439176

5'-Methylthioadenosine

5'-S-methyl-5'-thioadenosine is adenosine with the hydroxy group at C-5' substituted with a methylthio (methylsulfanyl) group. It has a role as a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a human metabolite and an algal metabolite. It is functionally related to an adenosine. — ChEBI

IUPAC name: (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol

Molecular formula: C11H15N5O3S
Molecular weight: 297.34 g/mol
Exact mass: 297.08956053 Da
XLogP3: -0.3
Topological polar surface area: 145.0 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 8
Covalent units: 1
Defined stereocentres: 4

Also known as

Methylthioadenosine5'-S-methyl-5'-thioadenosine5'-Deoxy-5'-(methylthio)adenosine5'-DEOXY-5'-METHYLTHIOADENOSINE5'-(Methylthio)adenosineS-methyl-5'-thioadenosine5'-S-MethylthioadenosineVitamin L(sub 2)

16 more reported names

5'-Deoxy(methylthio)adenosineNSC 335422UNII-634Z2VK3UQ5'-S-methyl-5'-thio-AdenosineS-methyl-5-thioadenosine(2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methylsulfanyl)methyl]oxolane-3,4-diolBRN 0042420CHEBI:175094-26-00-03675 (Beilstein Handbook Reference)NSC-3354221-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-beta-D-Ribofuranose1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-beta-delta-Ribofuranose7-(TETRAHYDRO-3,4-DIHYDROXY-5-(METHYLMERCAPTOMETHYL)-2-FURYL)ADENINE5-MTDA5'-methylthio-5'-deoxyadenosine(2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-((methylsulfanyl)methyl)oxolane-3,4-diol

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:17509
ChEMBL:CHEMBL277041
EPA DTXSID:DTXSID20179308
PubMed:37611859
PubMed:37545493
PubMed:31712395
PubMed:29968805
PubMed:27469509
PubMed:23040436
PubMed:23000879
PubMed:22854195
PubMed:22729051
PubMed:22685558
PubMed:22629346
PubMed:22563508

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for METHYLTHIOADENOSINE

INCI name

METHYLTHIOADENOSINE

Description

Adenosine thiomethylpentose

Record provenance

Inventory reference: 58194
Imported identity: METHYLTHIOADENOSINE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for METHYLTHIOADENOSINE

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Key data

CAS

2457-80-9

—

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#16679 · METHYLTHIOADENOSINE

Ingredients with overlapping formulation functions

METHYLSILANOL PEG-7 GLYCERYL COCOATESKIN CONDITIONING, SURFACTANT - EMULSIFYING

METHYLSILANOL SPIRULINATESKIN CONDITIONING

METHYLSILANOL TRI-PEG-8 GLYCERYL COCOATESKIN CONDITIONING, SURFACTANT - EMULSIFYING

METHYLSILANOL/SILICATE CROSSPOLYMERSKIN CONDITIONING

METHYLTHIOHEXYL ISOTHIOCYANATESKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

METROSIDEROS EXCELSA BARK/LEAF EXTRACTSKIN CONDITIONING

METROSIDEROS EXCELSA FLOWER/LEAF EXTRACTSKIN CONDITIONING

METSCHNIKOWIA HENANENSIS EXTRACTHUMECTANT, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How METHYLTHIOADENOSINE appears in the CosIng inventory

The CosIng inventory lists METHYLTHIOADENOSINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

METHYLTHIOADENOSINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

METHYLTHIOADENOSINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, METHYLTHIOADENOSINE carries the following function designation(s):

SKIN CONDITIONING

CAS 2457-80-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for METHYLTHIOADENOSINE

This page reproduces the CosIng inventory entry for METHYLTHIOADENOSINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research METHYLTHIOADENOSINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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