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CAS 53-84-9 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 5741115/10/2010

NICOTINAMIDE ADENINE DINUCLEOTIDE

Adenosine 5'-(trihydrogen diphosphate), 5'->5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium hydroxide, inner salt

NICOTINAMIDE ADENINE DINUCLEOTIDE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 53-84-9

CAS 53-84-9PubChem CID 5892

Nadide

NAD zwitterion is a NAD. It has a role as a geroprotector. It is functionally related to a deamido-NAD zwitterion. It is a conjugate base of a NAD(+). — ChEBI

IUPAC name: [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate

Molecular formula: C21H27N7O14P2
Molecular weight: 663.4 g/mol
Exact mass: 663.10912256 Da
XLogP3: -6.0
Topological polar surface area: 321.0 Å²
Hydrogen-bond donors: 7
Hydrogen-bond acceptors: 18
Covalent units: 1
Defined stereocentres: 8

Also known as

coenzyme Ibeta-NADCodehydrase ICodehydrogenase Inicotinamide adenine dinucleotidediphosphopyridine nucleotideCozymase Ibeta-Diphosphopyridine nucleotide

16 more reported names

EnzoprideCOZYMASENadidumNicotinamide-adenine dinucleotidecodehydrogenaseNadidaPyridine, nucleotide diphosphateAdenine-nicotinamide dinucleotideNadida [INN-Spanish]Nicotineamide adenine dinucleotideNadidum [INN-Latin].beta.-NADNadide [USAN:INN:BAN:JAN]EINECS 200-184-4NSC 20272BRN 3584133

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External database identifiers

ChEBI:CHEBI:44215
ChEMBL:CHEMBL1234613
EPA DTXSID:DTXSID2045236
PubMed:20491506
PubMed:16926152
PubMed:16601673
PubMed:15780941
PubMed:15744310
PubMed:15674325
PubMed:15658858
PubMed:15577910
PubMed:15491144
PubMed:15469825
PubMed:15100216
PubMed:12564954

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for NICOTINAMIDE ADENINE DINUCLEOTIDE

INCI name

NICOTINAMIDE ADENINE DINUCLEOTIDE

INN name

nadide

Description

Adenosine 5'-(trihydrogen diphosphate), 5'->5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium hydroxide, inner salt

Record provenance

Inventory reference: 57411
Imported identity: NICOTINAMIDE ADENINE DINUCLEOTIDE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for NICOTINAMIDE ADENINE DINUCLEOTIDE

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Key data

CAS

53-84-9

200-184-4

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#17428 · NICOTINAMIDE ADENINE DINUCLEOTIDE

Ingredients with overlapping formulation functions

NICOTIANA BENTHAMIANA SH-POLYPEDTIDE-7SKIN CONDITIONING

NICOTIANA BENTHAMIANA SH-POLYPEPTIDE-15 HEXAPEPTIDE-40SKIN CONDITIONING

NICOTIANA SYLVESTRIS LEAF CELL CULTURESKIN CONDITIONING

NICOTIANA TABACUM LEAF EXTRACTPERFUMING, SKIN CONDITIONING

NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATESKIN CONDITIONING, SKIN PROTECTING

NICOTINOYL DIPEPTIDE-22SKIN CONDITIONING

NICOTINOYL DIPEPTIDE-23SKIN CONDITIONING

NICOTINOYL DIPEPTIDE-24SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How NICOTINAMIDE ADENINE DINUCLEOTIDE appears in the CosIng inventory

The CosIng inventory lists NICOTINAMIDE ADENINE DINUCLEOTIDE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NICOTINAMIDE ADENINE DINUCLEOTIDE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NICOTINAMIDE ADENINE DINUCLEOTIDE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, NICOTINAMIDE ADENINE DINUCLEOTIDE carries the following function designation(s):

SKIN CONDITIONING

CAS 53-84-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for NICOTINAMIDE ADENINE DINUCLEOTIDE

This page reproduces the CosIng inventory entry for NICOTINAMIDE ADENINE DINUCLEOTIDE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research NICOTINAMIDE ADENINE DINUCLEOTIDE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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