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InventoryRef 5733715/10/2010

NEOPENTYL GLYCOL

2,2-Dimethyl-1,3-propanediol

NEOPENTYL GLYCOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 126-30-7
CAS 126-30-7PubChem CID 31344

Neopentyl glycol

2,2-dimethylpropane-1,3-diol is a white crystalline solid. Melting point 130 °C. — CAMEO Chemicals

IUPAC name
2,2-dimethylpropane-1,3-diol
Molecular formula
C5H12O2
Molecular weight
104.15 g/mol
Exact mass
104.083729621 Da
XLogP3
0.0
Topological polar surface area
40.5 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

2,2-DIMETHYL-1,3-PROPANEDIOLDimethylolpropaneNeopentanediolNeopentylene glycol1,3-Propanediol, 2,2-dimethyl-NeopentylglycolNeolDimethyltrimethylene glycol
16 more reported names
Hydroxypivalyl alcohol2,2-Dimethyltrimethylene glycolNexcoat 6002,2-Dimethyl-1,3 propanediolQI80HXD6S5ORISTAR NPGNSC-63661,3-Dihydroxy-2,2-dimethylpropaneNSC-55836NEOPENTYLGLYCOL ECAILLESCHEBI:143768dimethylol propaneRefChem:165329204-781-0NPG GlycolNSC 55836
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match31344

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: Flush with copious amounts of water.; SKIN: Wash with soap and copious amounts of water. (USCG, 1999) Source: CAMEO Chemicals
  • Note: This chemical does not meet GHS hazard criteria for 1.9% (19 of 1013) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H315 (21.1%): Causes skin irritation [Warning Skin corrosion/irritation]; H318 (74.9%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H319 (22%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P264, P264+P265, P280, P302+P352, P305+P351+P338, P305+P354+P338, P317, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1013 reports by companies from 9 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 19 of 1013 reports by companies.; There are 8 notifications provided by 994 of 1013 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: Hazardous Substances Data Bank (HSDB)
  • GHS Hazard Statements: H318: Causes serious eye damage [Danger Serious eye damage/eye irritation] Source: Hazardous Substances Data Bank (HSDB)
  • Precautionary Statement Codes: P264+P265, P280, P305+P354+P338, and P317 (click each P-code to see the statement) Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: Neopentyl glycol (NPG) is a solid. It is used in chemical synthesis, and in polyester manufacture. An insect repellent. HUMAN STUDIES: There are no data available. ANIMAL STUDIES: NPG was not irriating to skin in rabbits, and non sensitizing to the skin in the Murine Local Lymph Node Assay. NPG was practically non-toxic in acute studies in rats and guinea pigs. No treatment-related, adverse findings were observed at clinical examinations, clinical pathology and pathology up to a dose level of 1000 mg/kg bw/d in 90 day oral gavage studies in rats. In other rat study reproductive performance of the parent generation and development of the F1 generation were not affected after oral application of dose levels up to 1000 mg/kg bw/day. In male rats single i.p. injection of 2000 mg/kg bw resulted in a mid level of ataxia but no loss of righting reflex. NPG had no mutagenic activity in Salmonella typhimurium TA 100, TA 1535, TA 98, TA 1537, or in Escherichia coli WP2 uvrA tested with and without metabolic activation at dose levels up to 5000 ug/plate. NPG was not mutagenic in the HPRT locus assay under in vitro conditions in CHO cells in the absence and the presence Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: A BCF range of 0.3-0.5 was calculated in fish for neopentyl glycol at 10 ppm using carp (Cyprinus carpio) which were exposed over an 6-week period(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that neopentyl glycol is expected to have very high mobility in soil(SRC). Volatilization of neopentyl glycol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 3.1X1-07 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). Neopentyl glycol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 1.27X10-2 mm Hg at 25 °C(3). Utilizing the Japanese MITI test, 1.2% of the Theoretical BOD was reached in 2 weeks(4) indicating that biodegradation is not an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that neopentyl glycol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 3.1X10-7 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 122 and 890 days, respectively(SRC). According to a classification scheme(4), a BCF range of 0.3-0.5(5) suggests bioconcentration in aquatic organisms is low(SRC). Utilizing the Japanese MITI test, 1.2% of the Theoretical BOD was reached in 2 weeks(5) indicating that biodegradation is not an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), neopentyl glycol, which has a estimated vapor pressure of 1.27X10-2 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase neopentyl glycol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 44 hrs(SRC), calculated from its rate constant of 8.7X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Neopentyl glycol does not contain chromophores that absorb at wavelengths >290 nm(4) and, therefore, is not expected to be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Sources/Uses: Used to make plasticizers and polyesters and as modifier of alkyd resins; [Merck Index] Used in chemical synthesis and in the polymers industry; [IUCLID] Used to make large scale and fine chemicals, rubber products, plastic products, textiles, leather, fur, wood and wood products, pulp-paper and paper products, non-metallic mineral products (i.e. plasters and cement), in printing and reproduction of recorded media, building and construction work, scientific research and development, and consumer construction chemicals; [ECHA REACH Registrations] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Pulp and Paper Processing [Category: Industry]; Textiles (Fiber & Fabric Manufacturing) [Category: Industry]; Leather Tanning and Processing [Category: Industry]; Fur Dressing and Dyeing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: In the manufacture of plasticizers, polyesters, as modifier of alkyd resins. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Used in polyester manufacture. An insect repellent. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Application: 2,2-Dimethyl-1,3-propanediol may be used in the synthesis of: 2,2-dimethyl-1,3-propanediol cyclic phosphorochloridate; 2,2-dimethyl-1,3-propanediol cyclic phenylphosphonate; [1',3'-(2',2'-dimethylpropylene)]-2-iodo-3-octyl-5-thienylboronate; cyclic carbonate; 2,2-dimethyl-1,3-propanediol bis(cyclic-2,2-dimethyltrimethylene phosphite) Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Synthetic lubricants. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Neopentyl glycol is the main glycol in powder polyester formulations ... These polyesters are used, for example, in the automotive, domestic appliance, and general industries. Neopentyl glycol is also widely used in solvent borne polyester paints for coil coatings, cans, automotive paints, aerospace and transportation applications, and for other stoving enamels. Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for NEOPENTYL GLYCOL

INCI name

NEOPENTYL GLYCOL

Description

2,2-Dimethyl-1,3-propanediol

Record provenance

Inventory reference
57337
Imported identity
NEOPENTYL GLYCOL
Source update
15/10/2010
European Commission CosIng source notes
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Key data

CAS
126-30-7
EC
204-781-0
Restriction
—
Function
PLASTICISER
Softening and making supple synthetic polymers that otherwise could not be easily deformed, spread or worked out.
SOLVENT
Dissolving other components of cosmetics. Solvents are usually liquids (aqueous and nonaqueous).

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#17334 · NEOPENTYL GLYCOL

Ingredients with overlapping formulation functions

METHYL EPOXIDIZED SOYATEFILM FORMING, PLASTICISER
METHYL POLYRICINOLEATEBINDING, PLASTICISER
METHYLBUTENE/PIPERYLENE COPOLYMERPLASTICISER
N-ETHYLTOSYLAMIDE/EPOXY RESINFILM FORMING, PLASTICISER
NEOPENTYL GLYCOL DIPELARGONATEPLASTICISER, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT
OCTANEDIOLPLASTICISER
OCTYLDODECYL DILINOLEIC ACID/PROPANEDIOL COPOLYMERFILM FORMING, PLASTICISER, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, VISCOSITY CONTROLLING
OXIDIZED TALL OIL ACIDS/NEOPENTYL GLYCOL COPOLYMERFILM FORMING, PLASTICISER, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SURFACTANT - CLEANSING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How NEOPENTYL GLYCOL appears in the CosIng inventory

The CosIng inventory lists NEOPENTYL GLYCOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NEOPENTYL GLYCOL is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NEOPENTYL GLYCOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, NEOPENTYL GLYCOL carries the following function designation(s):

CAS 126-30-7 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for NEOPENTYL GLYCOL

This page reproduces the CosIng inventory entry for NEOPENTYL GLYCOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research NEOPENTYL GLYCOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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