Is NEOHESPERIDIN safe to use in EU cosmetics?

NEOHESPERIDIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 13241-33-3?

CAS 13241-33-3 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 5733515/10/2010

NEOHESPERIDIN

(S)-7-[[2-O-6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

NEOHESPERIDIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 13241-33-3

CAS 13241-33-3PubChem CID 442439

Neohesperidin

Neohesperidin is a flavanone glycoside that is hesperitin having an 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety attached to the 7-hydroxy group. It has a role as an antineoplastic agent and a plant metabolite. It is a member of 4'-methoxyflavanones, a neohesperidoside, a monomethoxyflavanone, a dihydroxyflavanone, a member of 3'-hydroxyflavanones, a disaccharide derivative and a flavanone glycoside. It is functionally related to a hesperetin. — ChEBI

IUPAC name: (2S)-7-[(2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one

Molecular formula: C28H34O15
Molecular weight: 610.6 g/mol
Exact mass: 610.18977037 Da
XLogP3: -0.5
Topological polar surface area: 234.0 Å²
Hydrogen-bond donors: 8
Hydrogen-bond acceptors: 15
Covalent units: 1
Defined stereocentres: 11

Also known as

OA5C88H3L0Hesperetin 7-O-neohesperidoside(S)-7-(((2-O-6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-oneFEMA NO. 4799CHEBI:59016(2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside4H-1-Benzopyran-4-one, 7-((2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (S)-RefChem:165257

16 more reported names

236-216-97-(4,5-dihydroxy-6-(hydroxymethyl)-3-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl)oxy-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-oneHesperetin-7-O-neohesperidosideNeohesperidin (Standard)Hesperetin-7-neohesperidoside4H-1-Benzopyran-4-one, 7-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-, (2S)-NSC 31048(2S)-NEOHESPERIDINNeohesperidin, >=90%UNII-OA5C88H3L0NEOHESPERIDIN [USP-RS]HY-N0101RNeohesperidin, analytical standardHY-N0101EINECS 236-216-9CS-6413

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:59016
ChEMBL:CHEMBL506398
EPA DTXSID:DTXSID60927668
PubMed:23000113
PubMed:22958058
PubMed:22957912
PubMed:22953908
PubMed:22953882
PubMed:22827164
PubMed:22804782
PubMed:22707269
PubMed:22634580
PubMed:22536197
PubMed:22454671
PubMed:22454667

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for NEOHESPERIDIN

INCI name

NEOHESPERIDIN

Description

(S)-7-[[2-O-6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one

Record provenance

Inventory reference: 57335
Imported identity: NEOHESPERIDIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for NEOHESPERIDIN

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Key data

CAS

13241-33-3

236-216-9

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#17325 · NEOHESPERIDIN

Ingredients with overlapping formulation functions

NELUMBO NUCIFERA STEM EXTRACTANTIOXIDANT, SKIN CONDITIONING

NEMATODE RH-POLYPEPTIDE-47HUMECTANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

NEOCHLORIS OLEOABUNDANS EXTRACTSKIN CONDITIONING

NEOFINETIA FALCATA CALLUS CULTURE EXTRACTSKIN CONDITIONING

NEOLENTINUS LEPIDEUS/STACHYS JAPONICA ROOT EXTRACT FERMENT FILTRATESKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

NEOLENTINUS LEPIDEUS/STACHYS RIEDERI ROOT EXTRACT FERMENT FILTRATESKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

NEOLEPISORUS FORTUNEI RHIZOME EXTRACTSKIN CONDITIONING

NEOLEPISORUS FORTUNEI ROOT EXTRACTSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How NEOHESPERIDIN appears in the CosIng inventory

The CosIng inventory lists NEOHESPERIDIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NEOHESPERIDIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NEOHESPERIDIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, NEOHESPERIDIN carries the following function designation(s):

SKIN CONDITIONING

CAS 13241-33-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for NEOHESPERIDIN

This page reproduces the CosIng inventory entry for NEOHESPERIDIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research NEOHESPERIDIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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