Is PANTOLACTONE safe to use in EU cosmetics?

PANTOLACTONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

How do I check if my formula contains PANTOLACTONE?

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InventoryRef 5693528/04/2017

PANTOLACTONE

2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, (R)-

PANTOLACTONE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 599-04-2

CAS 599-04-2PubChem CID 439368

D-Pantolactone

(R)-pantolactone is a butan-4-olide that is dihydrofuran-2(3H)-one substituted by a hydroxy group at position 3 and two methyl groups at position 4 (the R-stereoisomer). It has a role as a Saccharomyces cerevisiae metabolite. It is functionally related to a (R)-pantoic acid. — ChEBI

IUPAC name: (3R)-3-hydroxy-4,4-dimethyloxolan-2-one

Molecular formula: C6H10O3
Molecular weight: 130.14 g/mol
Exact mass: 130.062994177 Da
XLogP3: 0.5
Topological polar surface area: 46.5 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 1

Also known as

D-(-)-PantolactonePANTOLACTONE(R)-pantolactonepantoyl lactone(R)-Pantoyl lactone2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, (3R)-(3R)-dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanoneJ288D7O0JS

16 more reported names

CHEBI:16719(3R)-4,4-dimethyl-3-oxidanyl-oxolan-2-oneRefChem:8584942,4-dihydroxy-3,3-dimethylbutyric acid gamma-lactone209-963-3IID733HD2M(R)-3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-oneD-(-)-Pantoyl Lactone(R)-(-)-PantolactonePantothenic lactoneUNII-J288D7O0JS(R)-(-)-Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanonePANTOLACTONE [MI](3R)-3-hydroxy-4,4-dimethyl-tetrahydrofuran-2-onePANTOLACTONE, (-)-PANTOLACTONE, R-ISOMER

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External database identifiers

ChEBI:CHEBI:16719
ChEMBL:CHEMBL4587869
EPA DTXSID:DTXSID90881249
PubMed:20032887
PubMed:14709053
PubMed:14677931
PubMed:12662032
PubMed:12489941
PubMed:12098246
PubMed:11170253

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 79-50-5

CAS 79-50-5PubChem CID 989

(+-)-Pantolactone

DL-Pantolactone is a gamma-lactone. — ChEBI

IUPAC name: 3-hydroxy-4,4-dimethyloxolan-2-one

Molecular formula: C6H10O3
Molecular weight: 130.14 g/mol
Exact mass: 130.062994177 Da
XLogP3: 0.5
Topological polar surface area: 46.5 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

RefChem:390767DL-Pantolactone3-hydroxy-4,4-dimethyldihydrofuran-2(3H)-oneDL-Pantoyl Lactone2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanoneD,L-Pantolactone(+/-)-pantolactone

16 more reported names

3-hydroxy-4,4-dimethyl-tetrahydrofuran-2-one(+/-)-Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanonePantolyl lactone(D)-Pantolactone3-Hydroxy-4,4-dimethyldihydrofuran-2(3H)-one (DL-Pantolactone)D-(?)-Pantolactone(rs)-pantolactoneD-(-)-Pantolyl lactoneD-(-)-Pantoic acid lactoneUNII-IID733HD2M2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, (R)-s6027alpha-hydroxy-betaD,L-Pantolactone; DL-Pantolactone; (+/-)-Dihydro-3-hydroxy-4,4-dimethyl-2(3H)-furanone; Calcium Pantothenate Impurity CNSC 5926EINECS 201-210-7

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External database identifiers

ChEBI:CHEBI:194720
ChEMBL:CHEMBL4066633
EPA DTXSID:DTXSID40861637
PubMed:22398860
PubMed:22272147
PubMed:21871058
PubMed:21699171
PubMed:21192736
PubMed:19877634
PubMed:19876606
PubMed:18684335
PubMed:18661943
PubMed:18619350
PubMed:18461583
PubMed:18386931

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for PANTOLACTONE

INCI name

PANTOLACTONE

Description

2(3H)-Furanone, dihydro-3-hydroxy-4,4-dimethyl-, (R)-

Record provenance

Inventory reference: 56935
Imported identity: PANTOLACTONE
Source update: 28/04/2017

European Commission CosIng source notes

Annex records for PANTOLACTONE

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Key data

CAS

599-04-2; 79-50-5

209-963-3; 201-210-7

Restriction

—

Function

HUMECTANT: Retaining and/or preserving the moisture in a product during use.
SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#19039 · PANTOLACTONE

Ingredients with overlapping formulation functions

PANTOEA VAGANS/ERYNGIUM MARITIMUM CALLUS FERMENT EXTRACT FILTRATEHUMECTANT, SKIN CONDITIONING

PANTOEA VAGANS/HUMAN BONE MARROW STEM CELL CONDITIONED MEDIA/1,2-HEXANEDIOL FER…HUMECTANT, SKIN CONDITIONING

PANTOEA VAGANS/HUMAN KERATINOCYTE CONDITIONED MEDIA/1,2-HEXANEDIOL FERMENT EXTR…HUMECTANT, SKIN CONDITIONING

PANTOEA/RICE BRAN FERMENT EXTRACT FILTRATEHUMECTANT, SKIN CONDITIONING

PAPAVER RADICATUM CALLUS EXTRACTANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

PARACHLORELLA BEIJERINCKII EXTRACTHUMECTANT

PARACHLORELLA KESSLERI EXOPOLYSACCHARIDESHUMECTANT, SKIN CONDITIONING

PASSIFLORA ALATA CALLUS EXTRACTANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How PANTOLACTONE appears in the CosIng inventory

The CosIng inventory lists PANTOLACTONE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

PANTOLACTONE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

PANTOLACTONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, PANTOLACTONE carries the following function designation(s):

CAS 599-04-2; 79-50-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for PANTOLACTONE

This page reproduces the CosIng inventory entry for PANTOLACTONE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research PANTOLACTONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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