Is ECTOIN safe to use in EU cosmetics?

ECTOIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 96702-03-3?

CAS 96702-03-3 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains ECTOIN?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 5612215/10/2010

ECTOIN

4-Pyrimidinecarboxylic Acid, 1,4,5,6,-Tetrahydro-2-Methyl-, (4S)-

ECTOIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 96702-03-3

CAS 96702-03-3PubChem CID 126041

Ectoine

Ectoine is a carboxamidine heterocycle obtained by formal condensation of (2S)-2,4-diaminobutanoic acid with acetic acid. It has a role as an osmolyte. It is a monocarboxylic acid, a carboxamidine and a member of 1,4,5,6-tetrahydropyrimidines. It is a conjugate acid of an ectoinate. It is a tautomer of an ectoine zwitterion. — ChEBI

IUPAC name: (6S)-2-methyl-1,4,5,6-tetrahydropyrimidine-6-carboxylic acid

Molecular formula: C6H10N2O2
Molecular weight: 142.16 g/mol
Exact mass: 142.074227566 Da
XLogP3: -0.8
Topological polar surface area: 61.7 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 1

Also known as

ectoin7GXZ3858RY(4S)-2-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic acidCHEBI:27592NSC-6146161,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid(4S)-3,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid4-Pyrimidinecarboxylic acid, 1,4,5,6-tetrahydro-2-methyl-, (+)-

16 more reported names

(4S)-2-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylate(6S)-2-methyl-1,4,5,6-tetrahydropyrimidin-3-ium-6-carboxylateRefChem:5905672-methyl-3,4,5,6-tetrahydropyrimidine-4-carboxylic acidL-Ectoine(S)-2-Methyl-3,4,5,6-tetrahydropyrimidine-4-carboxylic acid(S)-2-Methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic acidUS9138393, Ectoine4-Pyrimidinecarboxylicacid, 3,4,5,6-tetrahydro-2-methyl-, (4S)-(S)-2-Methyl- 1,4,5,6-tetrahydropyrimidine-4-carboxylic acid(+)-1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acidUNII-7GXZ3858RY(S)-1,4,5,6-Tetrahydro-2-methyl-4-pyrimidincarbonsureEctoine?4CSEctoine (Standard)

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:27592
ChEMBL:CHEMBL1230264
EPA DTXSID:DTXSID50869280
PubMed:22989641
PubMed:22860907
PubMed:22850292
PubMed:22803353
PubMed:22702895
PubMed:22675587
PubMed:22675584
PubMed:22539022
PubMed:22527044
PubMed:22489184
PubMed:22480362
PubMed:22448254

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ECTOIN

INCI name

ECTOIN

Description

4-Pyrimidinecarboxylic Acid, 1,4,5,6,-Tetrahydro-2-Methyl-, (4S)-

Record provenance

Inventory reference: 56122
Imported identity: ECTOIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for ECTOIN

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Key data

CAS

96702-03-3

—

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#9723 · ECTOIN

Ingredients with overlapping formulation functions

ECLIPTA PROSTRATA LEAF POWDERSKIN CONDITIONING

ECLIPTA PROSTRATA POWDERHAIR CONDITIONING, SKIN CONDITIONING

ECLIPTA PROSTRATA STEM EXTRACTSKIN CONDITIONING

ECLIPTA PROSTRATA WAXSKIN CONDITIONING

EDGEWORTHIA CHRYSANTHA BARK EXTRACTSKIN CONDITIONING

EEL SKIN MUCUS EXTRACTSKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

EGGHAIR CONDITIONING, SKIN CONDITIONING

EGG OILHAIR CONDITIONING, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How ECTOIN appears in the CosIng inventory

The CosIng inventory lists ECTOIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ECTOIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ECTOIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ECTOIN carries the following function designation(s):

SKIN CONDITIONING

CAS 96702-03-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for ECTOIN

This page reproduces the CosIng inventory entry for ECTOIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ECTOIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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