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InventoryRef 5587413/03/2018

DISILOXANE

Bis(trimethylsyl)Oxide; Disiloxane, Hexamethyl-

DISILOXANE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 107-46-0
CAS 107-46-0PubChem CID 24764

Hexamethyldisiloxane

Hexamethyldisiloxane is an organosiloxane consisting of two trimethylsilyl groups covalently bound to a central oxygen. — ChEBI

IUPAC name
trimethyl(trimethylsilyloxy)silane
Molecular formula
C6H18OSi2
Molecular weight
162.38 g/mol
Exact mass
162.08961826 Da
Topological polar surface area
9.2 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

Disiloxane, hexamethyl-Oxybis(trimethylsilane)Fluka AGHexamethyl disiloxaneBis(trimethylsilyl)etherBelsil DM 0.65Bis(trimethylsilyl)oxideBistrimethylsilyl ether
16 more reported names
KF 96LSilane, oxybis(trimethyl-Dow corning 200OS 10D7M4659BPUAEC DISILOXANEMIRASIL HMSNSC-43346VOLASIL DM-0.65SI-TEC DM 0.65CHEBI:78002SF1000N-0.65CSTRefChem:7516SF1000N-0.65 cStXiameter PMX-200 Silicone Fluid 0.65 cSt203-492-7
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:78002

hexamethyldisiloxane

An organosiloxane consisting of two trimethylsilyl groups covalently bound to a central oxygen.

Formula
C6H18OSi2
Average mass
162.381 g/mol
Monoisotopic mass
162.08962 Da
Formal charge
0
  • organosiloxane — is a (CHEBI:48150)
  • organosiloxane — is a (CHEBI:48150)
Additional curated names
hexamethyldisiloxaneBis(trimethylsilyl)etherBis(trimethylsilyl)oxide((CH3)3Si)2OHMDSOOxybis(trimethylsilane)
Cross-references from this source

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2014-03-31. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match24764

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 0.1% (5 of 3584) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H225 (98.8%): Highly Flammable liquid and vapor [Danger Flammable liquids]; H400 (92.6%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410 (19.3%): Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard]; H411 (71.3%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P273, P280, P303+P361+P353, P370+P378, P391, P403+P235, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 3584 reports by companies from 24 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 5 of 3584 reports by companies.; There are 23 notifications provided by 3579 of 3584 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]; H400: Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]; H410: Very toxic to aquatic life with long lasting effects [Warning Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P273, P280, P302+P352, P303+P361+P353, P304+P340, P317, P319, P321, P332+P317, P362+P364, P370+P378, P391, P403+P235, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H225: Highly Flammable liquid and vapor [Danger Flammable liquids] Source: NITE-CMC
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P280, P303+P361+P353, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Environmental Bioconcentration: An estimated BCF of 340 was calculated for hexamethyldisiloxane(SRC), using a log Kow of 4.2(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is high(SRC), provided the compound is not metabolized by the organism(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 4,600(SRC), determined from a log Kow of 4.2(2) and a regression-derived equation(3), indicates that hexamethyldisiloxane is expected to have slight mobility in soil(SRC). Volatilization of hexamethyldisiloxane from moist soil surfaces is expected to be an important fate process(SRC) given a estimated Henry's Law constant of 0.0453 atm-cu m/mole(4). Hexamethyldisiloxane is expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 42.1 mm Hg(5). However, adsorption to soil is expected to attenuate volatilization(SRC). No biodegradation data regarding hexamethyldisiloxane were found; however, dimethyl siloxanes in general are highly resistant to biodegradation(6). As a member of this class biodegradation is not expected to be an important fate process. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Poly(dimethylsiloxane) (PDMS) fluids in intimate contact with many soils undergo siloxane redistribution and hydrolysis, resulting in the formation of low molecular weight cyclic and linear oligomers. Low molecular weight hydroxy-functional hydrolysis products are water soluble, and the cyclics and trimethylsiloxy-end-blocked oligomers are volatile, thus providing materials which can partition from the soil to the water and atmospheric environmental compartments(1). /Poly(dimethylsiloxane)/ Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 4,600(SRC), determined from a log Kow of 4.2(2) and a regression-derived equation(3), indicates that hexamethyldisiloxane is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon a Henry's Law constant of 0.0453 atm-cu m/mole(4). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 1.3 hours and 5 days, respectively(SRC). However, volatilization from water surfaces is expected to be attenuated by adsorption to suspended solids and sediment in the water column. The estimated volatilization half-life from a model pond is 30 days if adsorption is considered(5). According to a classification scheme(6), an estimated BCF of 340(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is high(SRC). Polydimethylsiloxane fluids undergo siloxane bond rearrangement to form low molecular weight linear and cyclic oligomers that are water soluble(8), indicating that hydrolysis of hexamethyldisiloxane may be an impor Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), hexamethyldisiloxane, which has a vapor pressure of 42.1 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase hexamethyldisiloxane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 18 days(SRC), calculated from its rate constant of 1.4x10-12 cu cm/molecule-sec at 25 °C(3). Methyl siloxanes are transparent to UV radiation >290 nm(4) and therefore hexamethyldisiloxane is not expected to undergo direct photolytic degradation(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Other; Binder; Dispersing agent; Solvent; Insulators; Anti-adhesive/cohesive; Terminator/Blocker; Surface modifier; Adhesion/cohesion promoter; Intermediate; Diluent; Not Known or Reasonably Ascertainable; Cleaning agent Source: EPA Chemical Data Reporting (CDR)
  • Sources/Uses: Used to make silicone fluids, elastomers, octamethylcyclotetrasiloxane, and fluorosilicone oils; Also used in cosmetics and in photolithography applications (adhesion promoter/priming agent); [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: Hydraulic fluid /Organo Silicate MLO 5277/ Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Chemical intermediate for silicone fluids and elastomers Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Hexamethyldisiloxane is used in cosmetic and personal care products, in the production of octamethylcyclotetrasiloxane, as an adhesion promotor-priming agent for photolithography applications, and as an end blocking agent in the production of fluorosilicone oils. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: /Used/ ... for headlights ... as a protective layer 20-30 nm thick ... effective diffusion barrier (condensed water resistance is 1000 times greater than without coating) ... . Other applications include the hydrophilic coating of contact lenses and the coating of medical materials to improve biocompatibility. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Used as antifoams in aqueous systems, in petroleum processing, and in laundry detergents ... In human and veterinary medicine ... used as antiflatulent agents ... Useful as lubricants (eg, for films, yarn, medical articles, wine corks, and fillers). /Polydimethylsiloxanes/ Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for DISILOXANE

INCI name

DISILOXANE

Description

Bis(trimethylsyl)Oxide;
Disiloxane, Hexamethyl-

Record provenance

Inventory reference
55874
Imported identity
DISILOXANE
Source update
13/03/2018
European Commission CosIng source notes
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Key data

CAS
107-46-0
EC
203-492-7
Restriction
—
Function
ANTIFOAMING
Suppressing foam during manufacturing or reducing the tendency of finished products to generate foam.
SKIN CONDITIONING
Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#9265 · DISILOXANE

Ingredients with overlapping formulation functions

DIMETHICONE SILYLATEANTIFOAMING
DIMETHICONOLANTIFOAMING, MOISTURISING, SKIN CONDITIONING - EMOLLIENT
DIPHENYL DIMETHICONEANTIFOAMING, HAIR CONDITIONING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SURFACTANT - EMUL…
DIPHENYLSILOXY PHENYL TRIMETHICONEANTIFOAMING, HAIR CONDITIONING, SKIN CONDITIONING
FUSEL WHEAT BRAN/STRAW GLYCOSIDESANTIFOAMING, SOLVENT, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING, SURFACTANT - HYDROTROPE
HEXASILOXANEANTIFOAMING
HEXYL ALCOHOLANTIFOAMING, PERFUMING, SOLVENT, SURFACTANT - CLEANSING, SURFACTANT - HYDROTROPE
HYDROGEN TRIFLUOROPROPYL DIMETHICONEANTIFOAMING, BINDING, EMULSION STABILISING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How DISILOXANE appears in the CosIng inventory

The CosIng inventory lists DISILOXANE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

DISILOXANE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

DISILOXANE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, DISILOXANE carries the following function designation(s):

CAS 107-46-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for DISILOXANE

This page reproduces the CosIng inventory entry for DISILOXANE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research DISILOXANE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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