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CAS 111109-77-4 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 5586915/10/2010

DIPROPYLENE GLYCOL DIMETHYL ETHER

Propane, oxybis(methoxy-

DIPROPYLENE GLYCOL DIMETHYL ETHER is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 111109-77-4

CAS 111109-77-4PubChem CID 86302

1-Methoxy-3-(3-methoxypropoxy)propane

IUPAC name: 1-methoxy-3-(3-methoxypropoxy)propane

Molecular formula: C8H18O3
Molecular weight: 162.23 g/mol
Exact mass: 162.125594432 Da
XLogP3: 0.5
Topological polar surface area: 27.7 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

RefChem:197053601-045-4Propane, 1,1'-oxybis[3-methoxy-Propane, oxybis(methoxy-Propane, oxybis[methoxy-Proglyde(R) DMMmethoxy-propyl-etherDSSTox_CID_22327

11 more reported names

DSSTox_RID_79997UNII-Q4KC92LJ05DSSTox_GSID_42327Q4KC92LJ05KWDCKLXGUZOEGM-UHFFFAOYSA-NDi(propylene glycol) dimethyl etherEthanol,2,6'-(hexadecylimino)bis-Tox21_301158Pentanedioicacid,6-oxo-,dimethylesterLS-13545CAS-111109-77-4

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL3182517
EPA DTXSID:DTXSID90274213
PubMed:12443040

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match86302

Attributed physical-property, hazard, environmental and use annotations.

Physical Description: Liquid; Other Solid; Liquid; CBI Source: EPA Chemical Data Reporting (CDR)
Physical Description: Clear colorless liquid; [Sigma-Aldrich MSDS] Mild odor; [Dow Chemical MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Note: This chemical does not meet GHS hazard criteria for 35.6% (339 of 953) of reports. Source: European Chemicals Agency (ECHA)
Signal: Warning Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H319 (64.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P264+P265, P280, P305+P351+P338, and P337+P317 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 953 reports by companies from 5 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 339 of 953 reports by companies.; There are 4 notifications provided by 614 of 953 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Note: This chemical does not meet GHS hazard criteria for 100% (272 of 272) of all reports. Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 272 of 272 companies. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 272 reports by companies from 1 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 272 of 272 reports by companies.; There are 0 notifications provided by 0 of 272 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Consumer Uses: Solvent; Not Known or Reasonably Ascertainable Source: EPA Chemical Data Reporting (CDR)

Industry Uses: Solvent; Not Known or Reasonably Ascertainable; Catalyst; Sealant (barrier); Cleaning agent Source: EPA Chemical Data Reporting (CDR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for DIPROPYLENE GLYCOL DIMETHYL ETHER

INCI name

DIPROPYLENE GLYCOL DIMETHYL ETHER

Description

Propane, oxybis(methoxy-

Record provenance

Inventory reference: 55869
Imported identity: DIPROPYLENE GLYCOL DIMETHYL ETHER
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for DIPROPYLENE GLYCOL DIMETHYL ETHER

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Key data

CAS

111109-77-4

404-640-5

Restriction

—

Function

SOLVENT: Dissolving other components of cosmetics. Solvents are usually liquids (aqueous and nonaqueous).

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#9241 · DIPROPYLENE GLYCOL DIMETHYL ETHER

Ingredients with overlapping formulation functions

DIPHENYL METHANEFRAGRANCE, SOLVENT

DIPROPYL ADIPATESKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT

DIPROPYL OXALATECHELATING, PLASTICISER, SOLVENT

DIPROPYLENE GLYCOLFRAGRANCE, PERFUMING, SOLVENT, VISCOSITY CONTROLLING

DISODIUM C12-14 PARETH-4 SULFOSUCCINATECLEANSING, SOLVENT, SURFACTANT - CLEANSING, SURFACTANT - FOAM BOOSTING

DISODIUM C13-15 HYDROXY ALKANOYL/ISOALKANOYL GLUTAMATECLEANSING, SOLVENT, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING, SURFACTANT - FOAM BOOSTING

DISODIUM SEBACATE/PALM KERNELATE TRIGLYCERIDECLEANSING, HAIR CONDITIONING, SOLVENT, SURFACTANT - CLEANSING, SURFACTANT - FOAM BOOSTING

DITRIDECYL ADIPATESKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How DIPROPYLENE GLYCOL DIMETHYL ETHER appears in the CosIng inventory

The CosIng inventory lists DIPROPYLENE GLYCOL DIMETHYL ETHER as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

DIPROPYLENE GLYCOL DIMETHYL ETHER is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

DIPROPYLENE GLYCOL DIMETHYL ETHER is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, DIPROPYLENE GLYCOL DIMETHYL ETHER carries the following function designation(s):

SOLVENT

CAS 111109-77-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for DIPROPYLENE GLYCOL DIMETHYL ETHER

This page reproduces the CosIng inventory entry for DIPROPYLENE GLYCOL DIMETHYL ETHER from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research DIPROPYLENE GLYCOL DIMETHYL ETHER and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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