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CAS 22608-11-3 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 5572515/10/2010

DEMETHOXYCURCUMIN

1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-hepta-1,6-dien-3,5-dione

DEMETHOXYCURCUMIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 22608-11-3

CAS 22608-11-3PubChem CID 5469424

Demethoxycurcumin

Demethoxycurcumin is a beta-diketone that is curcumin in which one of the methoxy groups is replaced by hydrogen. It is found in Curcuma zedoaria and Etlingera elatior. It has a role as a metabolite, an antineoplastic agent and an anti-inflammatory agent. It is a polyphenol, an enone, a beta-diketone and a diarylheptanoid. — ChEBI

IUPAC name: (1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione

Molecular formula: C20H18O5
Molecular weight: 338.4 g/mol
Exact mass: 338.11542367 Da
XLogP3: 3.3
Topological polar surface area: 83.8 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 0

Also known as

curcumin IIdesmethoxycurcuminDemethoxy CurcuminBHCFM4-Hydroxycinnamoyl(feroyl)methaneFeruloyl-P-hydroxycinnnamoylmethanedemethoxy-curcuminCHEBI:65737

16 more reported names

W2F8059T80RefChem:131719(1E,4Z,6E)-5-hydroxy-7-(4-hydroxy-3-methoxyphenyl)-1-(4-hydroxyphenyl)hepta-1,4,6-trien-3-one663-429-8monodemethoxycurcumin(E/Z)-Demethoxycurcumin1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)hepta-1,6-diene-3,5-dionecurcuminII(2E)-Demethoxy CurcuminC20H18O51,6-Heptadiene-3,5-dione, 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-p-Hydroxycinnamoyl-feruloylmethane(1E,6E)-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dionecid_53244764-hydroxycinnamoyl(feruloyl)methaneAC-34584

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:65737
ChEMBL:CHEMBL105360
EPA DTXSID:DTXSID00873751
PubMed:40449866
PubMed:39746524
PubMed:35752269
PubMed:34291863
PubMed:33861438
PubMed:33582110
PubMed:26264395
PubMed:23386263
PubMed:20691508
PubMed:19715544
PubMed:19188863
PubMed:18930076

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for DEMETHOXYCURCUMIN

INCI name

DEMETHOXYCURCUMIN

Description

1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-hepta-1,6-dien-3,5-dione

Record provenance

Inventory reference: 55725
Imported identity: DEMETHOXYCURCUMIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for DEMETHOXYCURCUMIN

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Key data

CAS

22608-11-3

—

Restriction

—

Function

ANTIOXIDANT: Inhibiting reactions promoted by oxygen, thus avoiding oxidation and rancidity.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#8311 · DEMETHOXYCURCUMIN

Ingredients with overlapping formulation functions

DEINOCOCCUS EXTRACTANTIOXIDANT, SKIN PROTECTING

DEINOXANTHINANTIOXIDANT

DELONIX REGIA FLOWER EXTRACTANTIOXIDANT; SKIN CONDITIONING - MISCELLANEOUS

DELPHINIUM ELATUM FLOWER EXTRACTANTIOXIDANT

DENDROBIUM CANDIDUM CALLUS POWDERANTIOXIDANT, HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

DENDROBIUM FIMBRIATUM EXTRACTANTIOXIDANT, SKIN PROTECTING

DENDROBIUM HUOSHANENSE PROTOCORM-LIKE BODIES EXTRACTANTIOXIDANT; SKIN PROTECTING; SKIN CONDITIONING - HUMECTANT

DENDROPANAX MORBIFERUS ADVENTITIOUS ROOT EXTRACTANTIMICROBIAL, ANTIOXIDANT, HAIR CONDITIONING, HUMECTANT, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How DEMETHOXYCURCUMIN appears in the CosIng inventory

The CosIng inventory lists DEMETHOXYCURCUMIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

DEMETHOXYCURCUMIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

DEMETHOXYCURCUMIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, DEMETHOXYCURCUMIN carries the following function designation(s):

ANTIOXIDANT

CAS 22608-11-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for DEMETHOXYCURCUMIN

This page reproduces the CosIng inventory entry for DEMETHOXYCURCUMIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research DEMETHOXYCURCUMIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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