What function does CYCLOTETRAGLUCOSE serve in cosmetics?

According to the EU CosIng inventory, CYCLOTETRAGLUCOSE carries the following function designation(s): BINDING, BULKING, HUMECTANT, SKIN CONDITIONING, VISCOSITY CONTROLLING.

What other records share CAS 159640-28-5?

CAS 159640-28-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains CYCLOTETRAGLUCOSE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 5555315/10/2010

CYCLOTETRAGLUCOSE

D-Glucose, cyclic tetramer

CYCLOTETRAGLUCOSE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 159640-28-5

CAS 159640-28-5PubChem CID 11686063

Cyclotetraglucose

Cyclobis-(1->6)-alpha-nigerosyl is a cyclic tetrasaccharide constructed from four alpha-glucopyranosyl residues joined by alternate alpha-(16)- and alpha-(13)-linkages. It is a tetrasaccharide and a macrocycle. It is functionally related to an isomaltose and a nigerose. — ChEBI

IUPAC name: (1R,3S,4R,5R,7S,10R,11S,12S,13R,14R,16S,17R,18R,20S,23R,24S,25S,26R,28R,30R)-5,18-bis(hydroxymethyl)-2,6,8,15,19,21,27,29-octaoxapentacyclo[21.3.1.13,7.110,14.116,20]triacontane-4,11,12,13,17,24,25,26,28,30-decol

Molecular formula: C24H40O20
Molecular weight: 648.6 g/mol
Exact mass: 648.21129366 Da
XLogP3: -7.5
Topological polar surface area: 317.0 Å²
Hydrogen-bond donors: 12
Hydrogen-bond acceptors: 20
Covalent units: 1
Defined stereocentres: 20

Also known as

CycloalternanCyclic nigerosylnigeroseCT-1180AS740C52alpha-D-Glucopyranose, o-alpha-D-glucopyranosyl-(1-3)-o-alpha-D-glucopyranosyl-(1-6)-o-alpha-D-glucopyranosyl-(1-3)-, cyclic 1,6'''-anhydrideRefChem:581287GlyTouCan:G67006KTCyclotetraglucose [INCI]

16 more reported names

UNII-80AS740C52cyclobis-(1->6)-alpha-nigerosylcyclobis-(1->3)-alpha-isomaltosylCycloisomaltotetraoseCYCLOTETRAOSECYCLOALTERNANOTETRAOSECyclobis-1,6-alpha-nigerosylINS NO.1504(II)INS NO.1504(I)CHEBI:136822INS-1504(II)INS-1504(I)E-1504(II)CYCLIC NIGEROSYL-(1->6)-NIGEROSEE-1504(I).ALPHA.-D-GLUCOPYRANOSE, O-.ALPHA.-D-GLUCOPYRANOSYL-(1-3)-O-.ALPHA.-D-GLUCOPYRANOSYL-(1-6)-O-.ALPHA.-D-GLUCOPYRANOSYL-(1-3)-, CYCLIC 1,6'''-ANHYDRIDE

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:136822
EPA DTXSID:DTXSID70166703

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CYCLOTETRAGLUCOSE

INCI name

CYCLOTETRAGLUCOSE

Description

D-Glucose, cyclic tetramer

Record provenance

Inventory reference: 55553
Imported identity: CYCLOTETRAGLUCOSE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for CYCLOTETRAGLUCOSE

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Key data

CAS

159640-28-5

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Restriction

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Function

BINDING: Providing adhesive properties during and after compression in cosmetic tablets and/or cakes.
BULKING: Non-reactive (chemically inert), solid ingredients that dilute other solids and/or increase the volume of cosmetic products.
HUMECTANT: Retaining and/or preserving the moisture in a product during use.
SKIN CONDITIONING: Maintaining the skin in good condition.
VISCOSITY CONTROLLING: Increasing or decreasing the viscosity (thickness) of cosmetics.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#7881 · CYCLOTETRAGLUCOSE

Ingredients with overlapping formulation functions

COLLOIDAL OATMEALABRASIVE, ABSORBENT, BULKING, SKIN PROTECTING

CORCHORUS CAPSULARIS POWDERBULKING, OPACIFYING

COTTONABSORBENT; ANTICAKING; BULKING; OPACIFYING; SLIP MODIFIER; SKIN CONDITIONING - MISCELLANEOUS

CROSCARMELLOSEBINDING, BULKING, GEL FORMING, VISCOSITY CONTROLLING

DEXTRINABSORBENT, BINDING, BULKING, VISCOSITY CONTROLLING

DIATOMACEOUS EARTHABRASIVE, ANTICAKING, BULKING, OPACIFYING

DICALCIUM PHOSPHATEABRASIVE, BULKING, OPACIFYING, ORAL CARE

DIETHYLENE GLYCOL ROSINATEBINDING, BULKING, DEPILATORY, FILM FORMING, PLASTICISER

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How CYCLOTETRAGLUCOSE appears in the CosIng inventory

The CosIng inventory lists CYCLOTETRAGLUCOSE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CYCLOTETRAGLUCOSE is also tagged with 5 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CYCLOTETRAGLUCOSE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, CYCLOTETRAGLUCOSE carries the following function designation(s):

CAS 159640-28-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for CYCLOTETRAGLUCOSE

This page reproduces the CosIng inventory entry for CYCLOTETRAGLUCOSE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research CYCLOTETRAGLUCOSE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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