Is CROTAMITON safe to use in EU cosmetics?

CROTAMITON is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 483-63-6?

CAS 483-63-6 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains CROTAMITON?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 5552415/10/2010

CROTAMITON

N-Ethyl-N-(2-methylphenyl)-2-butenamide

CROTAMITON is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 483-63-6

CAS 483-63-6PubChem CID 2883

Crotamiton

Crotamiton is a scabicidal and antipruritic agent available as a cream or lotion for topical use only. It is a colorless to slightly yellowish oil, having a faint amine-like odor. It is miscible with alcohol and with methanol. — DrugBank

IUPAC name: N-ethyl-N-(2-methylphenyl)but-2-enamide

Molecular formula: C13H17NO
Molecular weight: 203.28 g/mol
Exact mass: 203.131014166 Da
XLogP3: 2.8
Topological polar surface area: 20.3 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 0

Also known as

CrotanCrotamitoneCrotalginCrotamitonumD6S4O4XD0HCHEBI:31439NSC-758951RefChem:58614

16 more reported names

N-ethylcrotono-o-toluidide207-596-32-Butenamide, N-ethyl-N-(2-methylphenyl)-crotonyl-N-ethyl-o-toluidineEuraxCrotamiton (Cis/Trans Mixture)CrotaglinCrotamiton; N-Ethyl-N-(2-methylphenyl)but-2-enamideCrotamiton CRSDNTGGZPQPQTDQF-UHFFFAOYSA-NPrestwick0_000951Prestwick1_000951Spectrum2_001700Spectrum3_001081Spectrum4_001234NCIOpen2_004405

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL3183440
EPA DTXSID:DTXSID6040664
PubMed:28927721
PubMed:23003104
PubMed:22701866
PubMed:22578794
PubMed:22379965
PubMed:22191375
PubMed:22183101
PubMed:22051621
PubMed:21975006
PubMed:21907876
PubMed:21893234
PubMed:21603165

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CROTAMITON

INCI name

CROTAMITON

INN name

crotamiton

Description

N-Ethyl-N-(2-methylphenyl)-2-butenamide

Record provenance

Inventory reference: 55524
Imported identity: CROTAMITON
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for CROTAMITON

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Key data

CAS

483-63-6

207-596-3

Restriction

—

Function

ANTIMICROBIAL: Preventing and/or slowing down microbial growth.
SOLVENT: Dissolving other components of cosmetics. Solvents are usually liquids (aqueous and nonaqueous).

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#7623 · CROTAMITON

Ingredients with overlapping formulation functions

COCOBUTYRAMIDO HYDROXYSULTAINECLEANSING, SOLVENT, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING, SURFACTANT - FOAM BOOSTING, V…

COCONUT ALKANESSKIN CONDITIONING - EMOLLIENT, SOLVENT

COCOYL METHYL GLUCAMIDEHAIR CONDITIONING, SKIN CONDITIONING, SOLVENT, SURFACTANT - CLEANSING, VISCOSITY CONTROLLING

COLLAGEN WATERHUMECTANT, SKIN CONDITIONING, SOLVENT, VISCOSITY CONTROLLING

CRYPTOMERIA JAPONICA BARK EXTRACTDEODORANT, SOLVENT

CUPHEA VISCOSISSIMA SEED OILHAIR CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT

CYCLOETHOXYMETHICONESKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT

CYCLOHEPTASILOXANEANTICAKING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How CROTAMITON appears in the CosIng inventory

The CosIng inventory lists CROTAMITON as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CROTAMITON is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CROTAMITON is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, CROTAMITON carries the following function designation(s):

CAS 483-63-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for CROTAMITON

This page reproduces the CosIng inventory entry for CROTAMITON from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research CROTAMITON and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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