Is CREATINE safe to use in EU cosmetics?

CREATINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

How do I check if my formula contains CREATINE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 5552015/10/2010

CREATINE

Glycine, N-(Aminoiminomethyl)-N-Methyl-

CREATINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 57-00-1

CAS 57-00-1PubChem CID 586

Creatine

Creatine is a glycine derivative having methyl and amidino groups attached to the nitrogen. It has a role as a geroprotector, a nutraceutical, a neuroprotective agent, a mouse metabolite and a human metabolite. It is a glycine derivative and a member of guanidines. It is a conjugate acid of a creatinate. It is a tautomer of a creatine zwitterion. — ChEBI

IUPAC name: 2-[carbamimidoyl(methyl)amino]acetic acid

Molecular formula: C4H9N3O2
Molecular weight: 131.13 g/mol
Exact mass: 131.069476538 Da
XLogP3: -1.2
Topological polar surface area: 90.4 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

CreatinN-amidinosarcosineKreatinKrebiozonmethylglycocyamineN-methyl-N-guanylglycineGlycine, N-(aminoiminomethyl)-N-methyl-Pyrolysate

16 more reported names

(alpha-Methylguanido)acetic acidN-carbamimidoyl-N-methylglycineCosmocair C 100KreatinumNeotine2-(1-methylcarbamimidamido)acetic acidN-(aminoiminomethyl)-N-methylglycinealpha-Methylguanidino acetic acidNSC-8752(N-methylcarbamimidamido)acetic acid((amino(imino)methyl)(methyl)amino)acetic acidN-[(E)-AMINO(IMINO)METHYL]-N-METHYLGLYCINECHEBI:169192-(carbamimidoyl(methyl)amino)acetic acid[[Amino(imino)methyl](methyl)amino]acetic acidN-((E)-AMINO(IMINO)METHYL)-N-METHYLGLYCINE

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External database identifiers

ChEBI:CHEBI:16919
ChEMBL:CHEMBL283800
EPA DTXSID:DTXSID1040451
PubMed:33124720
PubMed:33022268
PubMed:29968805
PubMed:28558019
PubMed:24709313
PubMed:23125906
PubMed:23120950
PubMed:23117948
PubMed:23117947
PubMed:23115480
PubMed:23115467
PubMed:23112907

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

PubChem 2D chemical structure for CAS 6020-87-7

CAS 6020-87-7PubChem CID 80116

Creatine Monohydrate

Creatine Monohydrate is the monohydrate form of creatine similar or identical to endogenous creatine produced in the liver, kidneys, and pancreas. Creatine, in phosphate form, helps supply energy to muscle cells for contraction. After intense effort, when ATP deposits are depleted, creatine phosphate donates phosphate groups toward the fast synthesis of ATP. Dietary supplementation with creatine may improve muscle wasting associated with cancer and other chronic diseases. — NCI Thesaurus (NCIt)

IUPAC name: 2-[carbamimidoyl(methyl)amino]acetic acid;hydrate

Molecular formula: C4H11N3O3
Molecular weight: 149.15 g/mol
Exact mass: 149.08004122 Da
Topological polar surface area: 91.4 Å²
Hydrogen-bond donors: 4
Hydrogen-bond acceptors: 4
Covalent units: 2
Defined stereocentres: 0

Also known as

Creatine, monohydrateCreapureGlycine, N-(aminoiminomethyl)-N-methyl-, monohydrateUNII-9603LN7R2Q9603LN7R2QN-(Aminoiminomethyl)-N-methylglycine monohydrateCREATINE MONOHYDRATE [WHO-DD]Glycine, N-(aminoiminomethyl)-N-methyl-, hydrate (1:1)

16 more reported names

Creatine SupplementRefChem:128421N-(aminoiminomethyl)-N-methyl-Glycine, monohydrate611-954-82-(1-Methylguanidino)acetic acid hydrateCreatine hydrateCreatine (monohydrate)N-Guanyl-N-methylglycinecreatine-monohydrateCreatine (hydrate)Glycine, N-(aminoiminomethyl)-N-methyl-, hydrate (1:1); Creatine, monohydrate (8CI); Glycine, N-(aminoiminomethyl)-N-methyl-, monohydrate (9CI); CreapureCreatine monohydrate, >=98%Methylguanidoacetic acid monohydrates6023CS-W018178DS-9420

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External database identifiers

ChEMBL:CHEMBL5275950
EPA DTXSID:DTXSID10208954

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CREATINE

INCI name

CREATINE

Description

Glycine, N-(Aminoiminomethyl)-N-Methyl-

Record provenance

Inventory reference: 55520
Imported identity: CREATINE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for CREATINE

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Key data

CAS

57-00-1 / 6020-87-7

200-306-6 / -

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#7584 · CREATINE

Ingredients with overlapping formulation functions

CRATAEGUS OXYACANTHA FLOWER EXTRACTSKIN CONDITIONING

CRATAEGUS OXYACANTHA FRUIT EXTRACTSKIN CONDITIONING

CRATAEGUS PINNATIFIDA FRUIT EXTRACTSKIN CONDITIONING

CREAMSKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

CREPIDIASTRUM DENTICULATUM LEAF/STEM EXTRACTSKIN CONDITIONING

CREPIDIASTRUM LANCEOLATUM LEAF EXTRACTSKIN CONDITIONING

CREPIS SIBIRICA FLOWER/LEAF/STEM EXTRACTHAIR CONDITIONING, SKIN CONDITIONING

CRINUM ASIATICUM EXTRACTSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How CREATINE appears in the CosIng inventory

The CosIng inventory lists CREATINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CREATINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CREATINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, CREATINE carries the following function designation(s):

SKIN CONDITIONING

CAS 57-00-1 / 6020-87-7 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

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Source note for CREATINE

This page reproduces the CosIng inventory entry for CREATINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research CREATINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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