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InventoryRef 5518315/10/2010

CALCIUM PCA

L-Proline, 5-Oxo, Calcium Salt (2:1)

CALCIUM PCA is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Chemical identity and properties

PubChem 2D chemical structure for CAS 31377-05-6
CAS 31377-05-6PubChem CID 14559044

Calcium pidolate

The CIR Expert Panel concluded that PCA (i.e., 2-pyrrolidone-5-carboxylic acid), calcium PCA, magnesium PCA, potassium PCA, and sodium PCA are safe in cosmetics in the present practices of use and concentration described in this safety assessment. PCA and its salts should not be used in cosmetic products in which N-nitroso compounds can be formed. Cosmetic Ingredient Review (CIR)

IUPAC name
calcium bis((2S)-5-oxopyrrolidine-2-carboxylate)
Molecular formula
C10H12CaN2O6
Molecular weight
296.29 g/mol
Exact mass
296.0321270 Da
Topological polar surface area
138.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
6
Covalent units
3
Defined stereocentres
2

Also known as

Efical7Y2LVU5EKKCALCIDONECALCIUM PCARefChem:122896250-602-4Calcium (S)-5-oxopyrrolidine-2-carboxylatecalcium;(2S)-5-oxopyrrolidine-2-carboxylate
15 more reported names
Calcium bis(5-oxo-L-prolinate)UNII-7Y2LVU5EKKEINECS 250-602-4Ibercal (TN)CALCIUM OXOPROLINEL-CALCIUM PIDOLATECALCIUM L-PYROGLUTAMATECALCIUM PIDOLATE [MART.]CALCIUM PIDOLATE [WHO-DD]5-OXO-L-PROLINE CALCIUM SALTPIDOLIC ACID CALCIUM SALT (2:1)Calcium bis[(2S)-5-oxopyrrolidine-2-carboxylate]L-PROLINE, 5-OXO-, CALCIUM SALT (2:1)L-PYRROLIDONE CARBOXYLIC ACID, CALCIUM SALTPROLINE, 5-OXO-, CALCIUM SALT (2:1), L-
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CALCIUM PCA

INCI name

CALCIUM PCA

Description

L-Proline, 5-Oxo, Calcium Salt (2:1)

Record provenance

Inventory reference
55183
Imported identity
CALCIUM PCA
Source update
15/10/2010
European Commission CosIng source notes

Key data

Restriction
Function
HUMECTANT
Retaining and/or preserving the moisture in a product during use.
SKIN CONDITIONING
Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

Ingredients with overlapping formulation functions

Additional official and scientific sources

11 external databases to check this identity in

How CALCIUM PCA appears in the CosIng inventory

The CosIng inventory lists CALCIUM PCA as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CALCIUM PCA is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CALCIUM PCA is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, CALCIUM PCA carries the following function designation(s):

CAS 31377-05-6 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Source note for CALCIUM PCA

This page reproduces the CosIng inventory entry for CALCIUM PCA from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research CALCIUM PCA and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

Tools & next steps

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