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InventoryRef 5497315/10/2010

BRUCINE SULFATE

2,3-Dimethoxystrychnidin-10-one Sulfate (2:1)

BRUCINE SULFATE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Chemical identity and properties

PubChem 2D chemical structure for CAS 4845-99-2
CAS 4845-99-2PubChem CID 24721400

Brucine Sulfate

The CIR Expert Panel concluded that the available data are insufficient to support the safety of ... and Brucine Sulfate in cosmetic products, and that the available data are insufficient to support the safety of ... Brucine Sulfate as denaturants. Cosmetic Ingredient Review (CIR)

IUPAC name
bis((4aR,5aS,8aR,13aS,15aS,15bR)-10,11-dimethoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one);sulfuric acid
Molecular formula
C46H54N4O12S
Molecular weight
887.0 g/mol
Exact mass
886.34589434 Da
Topological polar surface area
185.0 Ų
Hydrogen-bond donors
2
Hydrogen-bond acceptors
14
Covalent units
3
Defined stereocentres
12

Also known as

Brucine sulphateKY7O12XPOQBrucine sulfate anhydrousBrucine sulphate anhydrousNSC-463Strychnidin-10-one, 2,3-dimethoxy-, sulfate (2:1)10,11-DIMETHOXYSTRYCHNINE SULFATERefChem:1080193
16 more reported names
225-432-9611-586-8Brucine sulfate [NF]Brucine sulfate (VAN)UNII-KY7O12XPOQBrucine, sulfate (2:1)NSC 463EINECS 225-432-9AI3-15304Brucine sulphate (2:1)2,3-Dimethoxystrychnidin-10-one sulfate (2:1)HCMSIGALSOEZRW-WIMNQIPBSA-NFS-697010,11-DIMETHOXYSTRYCHNINE SULPHATEB06722,3-DIMETHOXYSTRYCHNIDIN-10-ONE SULFATE
External database identifiers

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for BRUCINE SULFATE

INCI name

BRUCINE SULFATE

Description

2,3-Dimethoxystrychnidin-10-one Sulfate (2:1)

Record provenance

Inventory reference
54973
Imported identity
BRUCINE SULFATE
Source update
15/10/2010
European Commission CosIng source notes

Key data

Restriction
Function
DENATURANT
Rendering cosmetics unpalatable. Mostly added to cosmetics containing ethyl alcohol to make it unsuitable for ingestion.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

Ingredients with overlapping formulation functions

Additional official and scientific sources

11 external databases to check this identity in

How BRUCINE SULFATE appears in the CosIng inventory

The CosIng inventory lists BRUCINE SULFATE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

BRUCINE SULFATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

BRUCINE SULFATE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, BRUCINE SULFATE carries the following function designation(s):

CAS 4845-99-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Source note for BRUCINE SULFATE

This page reproduces the CosIng inventory entry for BRUCINE SULFATE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research BRUCINE SULFATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

Tools & next steps

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