What does the restriction note for 1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL mean?

The restriction field for 1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL reads: III/202. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 74918-21-1?

CAS 74918-21-1 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains 1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 4153515/10/2010

1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL

4,4'-[Propane-1,3-Diylbis(Oxy)]Bisbenzene-1,3-Diaminetetrahydrochloride

1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL is linked to 2 EU annex records on this page. Inventory note: III/202.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Restricted entry found Open this evidence	2	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 74918-21-1

CAS 74918-21-1PubChem CID 21895880

1,3-Bis-(2,4-diaminophenoxy)propane tetrahydrochloride

IUPAC name: 4-[3-(2,4-diaminophenoxy)propoxy]benzene-1,3-diamine;tetrahydrochloride

Molecular formula: C15H24Cl4N4O2
Molecular weight: 434.2 g/mol
Exact mass: 434.062387 Da
Topological polar surface area: 123.0 Å²
Hydrogen-bond donors: 8
Hydrogen-bond acceptors: 6
Covalent units: 5
Defined stereocentres: 0

Also known as

1,3-BIS(2,4-DIAMINOPHENOXY)PROPANE TETRAHYDROCHLORIDEColorex 13bisQ80X769AD4EINECS 278-022-74,4'-(Propane-1,3-diylbis(oxy))bisbenzene-1,3-diamine tetrahydrochloride4,4'-(PROPANE-1,3-DIYLBIS(OXY))BISBENZENE-1,3-DIAMINETETRAHYDROCHLORIDE1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE TETRAHYDROCHLORIDE

16 more reported names

1,3-Benzenediamine, 4,4'-[1,3-propanediylbis(oxy)]bis-, tetrahydrochloride4,4'-[propane-1,3-diylbis(oxy)]bisbenzene-1,3-diamine tetrahydrochloride1,3-BENZENEDIAMINE, 4,4'-(1,3-PROPANEDIYLBIS(OXY))BIS-, HYDROCHLORIDE (1:4)1,3-BENZENEDIAMINE, 4,4'-(1,3-PROPANEDIYLBIS(OXY))BIS-, TETRAHYDROCHLORIDERefChem:4140581,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL [INCI]4,4'-(Propane-1,3-diylbis(oxy))bis(benzene-1,3-diamine) tetrahydrochloride1,3-Bis(2,4-diaminophenoxy)propane 4HClC15H24Cl4N4O2AC-82924,4'-(PROPANE-1,3-DIYLBIS(OXY))BIS(BENZENE-1,3-DIAMINE) TETRAHCLUNII-Q80X769AD41,3-bis(2,4-diaminophenoxy)propane hydrochlorideUXPUOLAAWYPPLE-UHFFFAOYSA-N4-[3-(2,4-diaminophenoxy)propoxy]benzene-1,3-diamine tetrahydrochlorideDS-2687

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID40225891

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for 1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL

INCI name

1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL

Description

4,4'-[Propane-1,3-Diylbis(Oxy)]Bisbenzene-1,3-Diaminetetrahydrochloride

Record provenance

Inventory reference: 41535
Imported identity: 1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for 1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL

Annex III Restriction reference

Entry 202

1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE

CAS: 81892-72-0 - 74918-21-1

EC: 279-845-4 - 278-022-7

Annex III Shared CAS number

Entry 226

1,3-bis-(2,4-Diaminophenoxy)propane 1,3-bis-(2,4-Diaminophenoxy)propane HCl

CAS: 81892-72-0 / 74918-21-1

EC: 279-845-4 / 278-022-7

Key data

CAS

74918-21-1

278-022-7

Restriction

III/202

Function

HAIR DYEING: Imparting color to hair. Hair dyeing preparations may be temporary, semi-permanent, or permanent, depending on the length of time the colorant remains on the hair.

Records sharing a CAS or EC identity

1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL

Ingredients with overlapping formulation functions

1,2,4-BENZENETRIACETATEHAIR DYEING

1,2,4-TRIHYDROXYBENZENEHAIR DYEING

1,3,4,6-TETRAMETHYL-2-PYRIMIDONE SULFATEHAIR DYEING

1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANEHAIR DYEING

1,5-NAPHTHALENEDIOLHAIR DYEING

1,7-NAPHTHALENEDIOLHAIR DYEING

1-ACETOXY-2-METHYLNAPHTHALENEHAIR DYEING

1-ALLYL-3,4,6-TRIMETHYL-2-PYRIMIDONE BROMIDEHAIR DYEING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How 1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL appears in the CosIng inventory

The CosIng inventory lists 1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL as a cosmetic ingredient and this page links it to 2 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for 1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL reads: "III/202". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, 1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL carries the following function designation(s):

HAIR DYEING

CAS 74918-21-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for 1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL

This page combines the CosIng inventory entry for 1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL with 2 linked Annex II–VI records from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research 1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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