What other records share CAS 533-73-3?

CAS 533-73-3 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 3146528/07/2020

1,2,4-TRIHYDROXYBENZENE

Benzene-1,2,4-triol

1,2,4-TRIHYDROXYBENZENE is linked to 1 EU annex record on this page.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Evidence linked Prohibited Open this evidence	1	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Evidence linked Prohibited Open this evidence	1	English
ASEAN	Evidence linked Prohibited Open this evidence	1	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Evidence linked Prohibited Open this evidence	1	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Evidence linked Prohibited Open this evidence	1	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 533-73-3

CAS 533-73-3PubChem CID 10787

1,2,4-Benzenetriol

Benzene-1,2,4-triol is a benzenetriol carrying hydroxy groups at positions 1, 2 and 4. It has a role as a mouse metabolite. — ChEBI

IUPAC name: benzene-1,2,4-triol

Molecular formula: C6H6O3
Molecular weight: 126.11 g/mol
Exact mass: 126.031694049 Da
XLogP3: 1.5
Topological polar surface area: 60.7 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

1,2,4-TrihydroxybenzeneHydroxyhydroquinoneHydroxyquinol4-HydroxycatecholIMEXINE OAM173O8B04RDNSC-2818CHEBI:16971

16 more reported names

RefChem:71511208-575-1Oxyhydroquinone2,5-DihydroxyphenolOxyhydrochinonHydroquinone, hydroxy-1,3,4-Trihydroxybenzene1,3,4-BenzenetriolNSC 2818Oxyhydrochinon [German]CCRIS 2987EINECS 208-575-1BRN 2042863UNII-173O8B04RDAI3-193611,4-Benzenetriol

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:16971
ChEMBL:CHEMBL3092389
EPA DTXSID:DTXSID3040930
PubMed:39245080
PubMed:30327826
PubMed:24530881
PubMed:23776099
PubMed:23022512
PubMed:22701692
PubMed:22380602
PubMed:22292983
PubMed:22200301
PubMed:22102096
PubMed:22073085
PubMed:21912624

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for 1,2,4-TRIHYDROXYBENZENE

INCI name

1,2,4-TRIHYDROXYBENZENE

Description

Benzene-1,2,4-triol

Record provenance

Inventory reference: 31465
Imported identity: 1,2,4-TRIHYDROXYBENZENE
Source update: 28/07/2020

European Commission CosIng source notes

Annex records for 1,2,4-TRIHYDROXYBENZENE

Annex II Identified ingredient

Entry 1642

1,2,4-Trihydroxybenzene when used as a substance in hair and eyelash dye products

CAS: 533-73-3

EC: 208-575-1

Key data

CAS

533-73-3

208-575-1

Restriction

—

Function

HAIR DYEING: Imparting color to hair. Hair dyeing preparations may be temporary, semi-permanent, or permanent, depending on the length of time the colorant remains on the hair.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#101 · 1,2,4-TRIHYDROXYBENZENE

Ingredients with overlapping formulation functions

(CALENDULA OFFICINALIS/SAFFLOWER FLOWER)/(ACHILLEA MILLEFOLIUM FLOWER/LEAF/STEM…HAIR DYEING

1,2,4-BENZENETRIACETATEHAIR DYEING

1,3,4,6-TETRAMETHYL-2-PYRIMIDONE SULFATEHAIR DYEING

1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANEHAIR DYEING

1,3-BIS-(2,4-DIAMINOPHENOXY)PROPANE HCLHAIR DYEING

1,5-NAPHTHALENEDIOLHAIR DYEING

1,7-NAPHTHALENEDIOLHAIR DYEING

1-ACETOXY-2-METHYLNAPHTHALENEHAIR DYEING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How 1,2,4-TRIHYDROXYBENZENE appears in the CosIng inventory

The CosIng inventory lists 1,2,4-TRIHYDROXYBENZENE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

1,2,4-TRIHYDROXYBENZENE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

1,2,4-TRIHYDROXYBENZENE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

According to the EU CosIng inventory, 1,2,4-TRIHYDROXYBENZENE carries the following function designation(s):

HAIR DYEING

CAS 533-73-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for 1,2,4-TRIHYDROXYBENZENE

This page combines the CosIng inventory entry for 1,2,4-TRIHYDROXYBENZENE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research 1,2,4-TRIHYDROXYBENZENE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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