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InventoryRef 4130302/03/2011

2,4-XYLENOL

2,4-Xylenol

2,4-XYLENOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 105-67-9
CAS 105-67-9PubChem CID 7771

2,4-Dimethylphenol

2,4-xylenol is a member of the class of phenols that phenol substituted by methyl groups at positions 2 and 4. It has a role as a volatile oil component and a disinfectant. It is a member of phenols and an aromatic fungicide. It derives from a hydride of a m-xylene. — ChEBI

IUPAC name
2,4-dimethylphenol
Molecular formula
C8H10O
Molecular weight
122.16 g/mol
Exact mass
122.073164938 Da
XLogP3
2.3
Topological polar surface area
20.2 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

2,4-Xylenolm-XylenolGallexPhenol, 2,4-dimethyl-4,6-Dimethylphenol1-Hydroxy-2,4-dimethylbenzene4-Hydroxy-1,3-dimethylbenzeneLysol Brand disinfectant
16 more reported names
2,4-DMPBulk Lysol Brand DisinfectantGable-Tite Dark Creosote (Creola)NSC-3829Benzene, 2,4-dimethyl-1-hydroxy-Gable-Tite Light Creosote (Creola)EPA Pesticide Chemical Code 0868044-Hydroxy-m-xyleneAI3-176125OD803C081CHEBI:34241RefChem:82546203-321-6BacticinRCRA waste number U101NSC 3829
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

EMBL-EBI ChEBI
Exact identifier matchCHEBI:34241

2,4-xylenol

A member of the class of phenols that phenol substituted by methyl groups at positions 2 and 4.

Formula
C8H10O
Average mass
122.167 g/mol
Monoisotopic mass
122.07316 Da
Formal charge
0
  • phenols — is a (CHEBI:33853)
  • aromatic fungicide — is a (CHEBI:87034)
  • disinfectant — has role (CHEBI:48219)
  • volatile oil component — has role (CHEBI:27311)
  • m-xylene — has parent hydride (CHEBI:28488)
  • disinfectant — has role (CHEBI:48219)
  • volatile oil component — has role (CHEBI:27311)
  • phenols — is a (CHEBI:33853)
  • aromatic fungicide — is a (CHEBI:87034)
Additional curated names
2,4-dimethylphenol1,3-dimethyl-4-hydroxybenzene1-hydroxy-2,4-dimethylbenzene2,4-DMP2-methyl-p-cresol4,6-dimethylphenol4-hydroxy-1,3-dimethylbenzene4-hydroxy-m-xyleneasym-m-xylenolm-xylenolgallex
Cross-references from this source
  • CAS: 105-67-9 — ChemIDplus
  • CAS: 105-67-9 — NIST Chemistry WebBook
  • MANUAL_X_REF: 13839123 — ChemSpider
  • MANUAL_X_REF: 1619 — PPDB
  • MANUAL_X_REF: C00052596 — KNApSAcK
  • MANUAL_X_REF: C14582 — KEGG COMPOUND
  • MANUAL_X_REF: CPD-18280 — MetaCyc
  • MANUAL_X_REF: HMDB0245456 — HMDB
  • MANUAL_X_REF: N0D — PDBeChem
  • REGISTRY_NUMBER: 636244 — Reaxys

Mapped by: Exact CAS cross-reference in the ChEBI compound record. Source updated: 2022-05-06. Retrieved: 2026-08-31. Open source record

NIH PubChem PUG-View
Exact identifier match7771

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whene Source: CAMEO Chemicals
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H301: Toxic if swallowed [Danger Acute toxicity, oral]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H411: Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P260, P262, P264, P270, P273, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P361+P364, P363, P391, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H301 (99.1%): Toxic if swallowed [Danger Acute toxicity, oral]; H311 (99.1%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317 (37.4%): May cause an allergic skin reaction [Warning Sensitization, Skin]; H318 (41.4%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H411 (99.8%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P260, P261, P262, P264, P264+P265, P270, P272, P273, P280, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P333+P317, P361+P364, P362+P364, P363, P391, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 527 reports by companies from 15 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure]; H401: Toxic to aquatic life [Hazardous to the aquatic environment, acute hazard]; H412: Harmful to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P260, P264, P264+P265, P270, P273, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P308+P316, P316, P317, P319, P321, P362+P364, P363, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H303: May be harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • Precautionary Statement Codes: P260, P261, P264, P264+P265, P270, P272, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P308+P316, P316, P317, P319, P321, P333+P317, P362+P364, P363, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Environmental Bioconcentration: A BCF of 150 was determined for 2,4-dimethylphenol in bluegill sunfish and 28 days exposure(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is high. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 430(SRC), determined from a log Kow of 2.30(2) and a regression-derived equation(3), indicates that 2,4-dimethylphenol is expected to have moderate mobility in soil(SRC). Volatilization of 2,4-dimethylphenol from moist soil surfaces is expected to be an important fate process(SRC) given a Henry's Law constant of 1.7X10-5 atm-cu m/mole (4). 2,4-Dimethylphenol is not expected to volatilize from dry soil surfaces(3) based upon a vapor pressure of 0.102 mm Hg at 25 °C(5). 2,4-Dimethylphenol has been reported to completely biodegrade from soil in 4 days at a temperature of 19 °C(6) and the biodegradation half-life of 2,4-dimethylphenol from Texas soil and Mississippi soil was determined to be 1.5 and 3.5 days, respectively(7). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), a Koc value of 430(SRC), determined from a log Kow of 2.30(2) and a regression-derived equation(3), indicates that 2,4-dimethylphenol is expected to adsorb very little to suspended solids and sediment in water(SRC). 2,4-Dimethylphenol is expected to volatilize from water surfaces(3,SRC) based upon a Henry's Law constant of 1.7X10-5 atm-cu m/mole(4). Estimated volatilization half-lives for a model river and model lake are 3 days and 22 days, respectively(3,SRC). According to a classification scheme(5), a BCF of 150 in bluegill sunfish(6) suggests bioconcentration in aquatic organisms is moderate(SRC). In humic waters, degradation by the reaction with peroxy radicals should ensue with a half-life on the order of hours(7). 2,4-Dimethylphenol is not expected to undergo hydrolysis in the environment due to the lack of hydrolyzable functional groups(3). Screening studies indicate that 95% removal of 2,4-dimethylphenol was obtained after 5 days using an activated sludge inoculum(8). In addition, it has been reported that 2,4-dimethylphenol was readily degraded in St. Lawrence River water(9). Methanogenic consortia failed to anaerobically Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2,4-dimethylphenol, which has a vapor pressure of 0.102 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2,4-dimethylphenol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 5.3 hours(SRC) from its rate constant of 7.20X10-11 cu cm/molecule-sec at 25 °C(3). 2,4-Dimethylphenol has an absorption band at 296 nm (maximum) and extends over 320 nm, thus making it a candidate for direct photochemical degradation(5,6). Night-time degradation in urban areas should occur rapidly through reaction with atmospheric nitrate radicals, as rate constants for this reaction with phenolic compounds are approximately 250 times faster than with hydroxyl radicals(7,SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Industry Uses: Solvent; Surfactant (surface active agent); Monomers; Fuel; Cleaning agent; Corrosion inhibitor; Intermediate Source: EPA Chemical Data Reporting (CDR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
EMBL-EBI ChEBIExact match2026-08-31
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for 2,4-XYLENOL

INCI name

2,4-XYLENOL

Description

2,4-Xylenol

Record provenance

Inventory reference
41303
Imported identity
2,4-XYLENOL
Source update
02/03/2011
European Commission CosIng source notes
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Key data

CAS
105-67-9
EC
203-321-6
Restriction
—
Function
PERFUMING
Used for perfume and aromatic raw materials.

Ingredients with overlapping formulation functions

2,4-DIMETHYLPYRIDINEPERFUMING
2,4-HEXADIENALPERFUMING
2,4-HEXADIENOLPERFUMING
2,4-HEXADIENYL ACETATEPERFUMING
2,5,5-TRIMETHYL-2-PHENYL-1,3-DIOXANEPERFUMING
2,5,6-TRIMETHYL-2-CYCLOHEXENONEPERFUMING
2,5-DIHYDRO-4-METHYLTHIAZOL-5-ETHANOLPERFUMING
2,5-DIMETHYL-2-VINYLHEX-4-ENALPERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How 2,4-XYLENOL appears in the CosIng inventory

The CosIng inventory lists 2,4-XYLENOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

2,4-XYLENOL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

2,4-XYLENOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, 2,4-XYLENOL carries the following function designation(s):

CAS 105-67-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for 2,4-XYLENOL

This page reproduces the CosIng inventory entry for 2,4-XYLENOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research 2,4-XYLENOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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