Is 2,4-HEXADIENOL safe to use in EU cosmetics?

2,4-HEXADIENOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 111-28-4?

CAS 111-28-4 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains 2,4-HEXADIENOL?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 4014202/03/2011

2,4-HEXADIENOL

Hexa-2,4-dien-1-ol

2,4-HEXADIENOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 111-28-4

CAS 111-28-4PubChem CID 8104

2,4-Hexadien-1-OL

Hexa-2,4-dienol is a metabolite found in or produced by Saccharomyces cerevisiae. — Yeast Metabolome Database (YMDB)

IUPAC name: hexa-2,4-dien-1-ol

Molecular formula: C6H10O
Molecular weight: 98.14 g/mol
Exact mass: 98.073164938 Da
XLogP3: 1.1
Topological polar surface area: 20.2 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 0

Also known as

RefChem:785768Sorbyl alcoholhexa-2,4-diene-1-ol2,a4-aHexadien-a1-aolE,E-2,4-Hexadien-1-olDB-019214

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

EPA DTXSID:DTXSID8047632
PubMed:20049080
PubMed:19574215
PubMed:17100332
PubMed:16340038
PubMed:16048335
PubMed:15813702
PubMed:12375967
PubMed:11846653
PubMed:11517682

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match8104

Attributed physical-property, hazard, environmental and use annotations.

Physical Description: Solid with an agreeable odor of freshly cut grass; mp = 30.5-31.5 deg C; [Merck Index] Colorless solid with a green herbal odor; [Bedoukian Research MSDS] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
Physical Description: colourless solid; green, vegetable aroma Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Solubility: Insoluble in water; Soluble in fat Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Solubility: soluble (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Vapor Pressure: 0.02 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Signal: Danger Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H302 (99.2%): Harmful if swallowed [Warning Acute toxicity, oral]; H311 (99.6%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (99.6%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P262, P264, P264+P265, P270, P280, P301+P317, P302+P352, P305+P351+P338, P316, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 261 reports by companies from 3 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Sources/Uses: Used as a reagent in organic chemistry; [Merck Index] Used as a flavoring agent; [FDA] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for 2,4-HEXADIENOL

INCI name

2,4-HEXADIENOL

Description

Hexa-2,4-dien-1-ol

Record provenance

Inventory reference: 40142
Imported identity: 2,4-HEXADIENOL
Source update: 02/03/2011

European Commission CosIng source notes

Annex records for 2,4-HEXADIENOL

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Key data

CAS

111-28-4

203-853-9

Restriction

—

Function

PERFUMING: Used for perfume and aromatic raw materials.

Ingredients with overlapping formulation functions

2,4-DIMETHYLCYCLOHEXYLMETHYL ACETATEPERFUMING

2,4-DIMETHYLHEPTA-2,2-DIENALPERFUMING

2,4-DIMETHYLPYRIDINEPERFUMING

2,4-HEXADIENALPERFUMING

2,4-HEXADIENYL ACETATEPERFUMING

2,4-XYLENOLPERFUMING

2,5,5-TRIMETHYL-2-PHENYL-1,3-DIOXANEPERFUMING

2,5,6-TRIMETHYL-2-CYCLOHEXENONEPERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How 2,4-HEXADIENOL appears in the CosIng inventory

The CosIng inventory lists 2,4-HEXADIENOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

2,4-HEXADIENOL is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

2,4-HEXADIENOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, 2,4-HEXADIENOL carries the following function designation(s):

PERFUMING

CAS 111-28-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for 2,4-HEXADIENOL

This page reproduces the CosIng inventory entry for 2,4-HEXADIENOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research 2,4-HEXADIENOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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