Is SKATOLE safe to use in EU cosmetics?

SKATOLE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 83-34-1?

CAS 83-34-1 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains SKATOLE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 4110502/03/2011

SKATOLE

3-Methylindole

SKATOLE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 83-34-1

CAS 83-34-1PubChem CID 6736

Skatole

Skatole is a methylindole carrying a methyl substituent at position 3. It is produced during the anoxic metabolism of L-tryptophan in the mammalian digestive tract. It has a role as a mammalian metabolite and a human metabolite. — ChEBI

IUPAC name: 3-methyl-1H-indole

Molecular formula: C9H9N
Molecular weight: 131.17 g/mol
Exact mass: 131.073499291 Da
XLogP3: 2.6
Topological polar surface area: 15.8 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 0
Covalent units: 1
Defined stereocentres: 0

Also known as

3-METHYLINDOLEScatole1H-Indole, 3-methyl-SkatolIndole, 3-methyl-beta-MethylindoleFEMA No. 30193-methyl-indole

16 more reported names

SKATOLUM9W945B5H7RNSC-122024CHEBI:91713 MethylindoleRefChem:58525201-471-73-MI3-methyl indole3-Methyl-4,5-benzopyrrole.beta.-MethylindoleNSC 122024Skatole, >=98%CAS-83-34-1CCRIS 8961HSDB 3511

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:9171
ChEMBL:CHEMBL1329793
EPA DTXSID:DTXSID8021775
PubMed:40947077
PubMed:40907674
PubMed:32092453
PubMed:31201936
PubMed:30599194
PubMed:28571685
PubMed:24333270
PubMed:23028517
PubMed:23009104
PubMed:22901340
PubMed:22753155
PubMed:22639609

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for SKATOLE

INCI name

SKATOLE

Description

3-Methylindole

Record provenance

Inventory reference: 41105
Imported identity: SKATOLE
Source update: 02/03/2011

European Commission CosIng source notes

Annex records for SKATOLE

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Key data

CAS

83-34-1

201-471-7

Restriction

—

Function

PERFUMING: Used for perfume and aromatic raw materials.

Ingredients with overlapping formulation functions

SCHINUS MOLLE FRUIT EXTRACTHUMECTANT, PERFUMING

SCHINUS MOLLE OILFRAGRANCE, PERFUMING, SKIN CONDITIONING

SCLAREOLPERFUMING

SCLAREOLIDEFRAGRANCE, PERFUMING, SKIN CONDITIONING

SODIUM CINNAMATEANTIMICROBIAL, PERFUMING

SORBITOLFRAGRANCE, HUMECTANT, PERFUMING, SKIN CONDITIONING

STEAROPTENESPERFUMING

STYRALYL ALCOHOLPERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How SKATOLE appears in the CosIng inventory

The CosIng inventory lists SKATOLE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

SKATOLE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

SKATOLE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, SKATOLE carries the following function designation(s):

PERFUMING

CAS 83-34-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for SKATOLE

This page reproduces the CosIng inventory entry for SKATOLE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research SKATOLE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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