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CAS 1124-11-4 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 4107202/03/2011

TETRAMETHYLPYRAZINE

Q: Is TETRAMETHYLPYRAZINE safe to use in EU cosmetics?

TETRAMETHYLPYRAZINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

Q: What function does TETRAMETHYLPYRAZINE serve in cosmetics?

According to the EU CosIng inventory, TETRAMETHYLPYRAZINE carries the following function designation(s): PERFUMING.

2,3,5,6-Tetramethylpyrazine

TETRAMETHYLPYRAZINE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 1124-11-4

CAS 1124-11-4PubChem CID 14296

Tetramethylpyrazine

Tetramethylpyrazine is a member of the class of pyrazines that is pyrazine in which all four hydrogens have been replaced by methyl groups. An alkaloid extracted from Chuanxiong (Ligusticum wallichii). It has a role as an antineoplastic agent, a vasodilator agent, a platelet aggregation inhibitor, a neuroprotective agent, an apoptosis inhibitor and a bacterial metabolite. It is an alkaloid and a member of pyrazines. — ChEBI

IUPAC name: 2,3,5,6-tetramethylpyrazine

Molecular formula: C8H12N2
Molecular weight: 136.19 g/mol
Exact mass: 136.100048391 Da
XLogP3: 1.3
Topological polar surface area: 25.8 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

LigustrazineChuanxiongzineTetrapyrazinechuanxingzineFEMA No. 3237CHUANXIONGQINTMPZ2,3,5,6,-Tetramethyl-1,4-pyrazine

16 more reported names

V80F4IA5XGNSC-36080NSC-46451CHEBI:133246tetramethyl pyrazineRefChem:799162214-391-2Pyrazine, tetramethyl-Bs factorTetramethylpyrazinLigustizine2,3,5,6-Tetramethyl pyrazineLiqustrazineEINECS 214-391-2NSC 36080Opera_ID_849

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:133246
ChEMBL:CHEMBL303697
EPA DTXSID:DTXSID6047070
PubMed:23563941
PubMed:23117466
PubMed:23058057
PubMed:22972787
PubMed:22928823
PubMed:22855036
PubMed:22803382
PubMed:22710373
PubMed:22689424
PubMed:22679731
PubMed:22626794
PubMed:22611379

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match14296

Attributed physical-property, hazard, environmental and use annotations.

Boiling Point: 190.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
Boiling Point: 190 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

LogP: 1.28 Source: Human Metabolome Database (HMDB)

Melting Point: 86 °C Source: Human Metabolome Database (HMDB)

Physical Description: Solid Source: Human Metabolome Database (HMDB)
Physical Description: white crystals or powder with a musty, fermented, coffee odour Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Solubility: slightly soluble in water; soluble in oils, propylene glycol, organic solvents Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Solubility: very soluble (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Solubility: <0.1 [ug/mL] (The mean of the results at pH 7.4) Source: Sanford-Burnham Center for Chemical Genomics

Signal: Warning Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] Source: European Chemicals Agency (ECHA)
Precautionary Statement Codes: P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 1685 reports by companies from 8 notifications to the ECHA C&L Inventory.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
Signal: Warning Source: NITE-CMC
GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral] Source: NITE-CMC
Precautionary Statement Codes: P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement) Source: NITE-CMC

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for TETRAMETHYLPYRAZINE

INCI name

TETRAMETHYLPYRAZINE

Description

2,3,5,6-Tetramethylpyrazine

Record provenance

Inventory reference: 41072
Imported identity: TETRAMETHYLPYRAZINE
Source update: 02/03/2011

European Commission CosIng source notes

Annex records for TETRAMETHYLPYRAZINE

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Key data

CAS

1124-11-4

214-391-2

Restriction

—

Function

PERFUMING: Used for perfume and aromatic raw materials.

Ingredients with overlapping formulation functions

TETRAMETHYLCYCLOHEXENE-1-PROPANOLPERFUMING

TETRAMETHYLHEXADEC-2-ENYL ACETATEPERFUMING

TETRAMETHYLHEXANALPERFUMING

TETRAMETHYLNONA-6,8-DIEN-3-ONEPERFUMING

THEOBROMA GRANDIFLORUM FRUIT JUICEANTIOXIDANT, FRAGRANCE, HUMECTANT, PERFUMING

THUJA OCCIDENTALIS LEAF EXTRACTANTIOXIDANT, BLEACHING, HAIR CONDITIONING, PERFUMING, SKIN CONDITIONING

THUJA OCCIDENTALIS LEAF OILFRAGRANCE, PERFUMING, TONIC

THUJA OCCIDENTALIS STEM OILPERFUMING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How TETRAMETHYLPYRAZINE appears in the CosIng inventory

The CosIng inventory lists TETRAMETHYLPYRAZINE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

TETRAMETHYLPYRAZINE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

TETRAMETHYLPYRAZINE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, TETRAMETHYLPYRAZINE carries the following function designation(s):

PERFUMING

CAS 1124-11-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for TETRAMETHYLPYRAZINE

This page reproduces the CosIng inventory entry for TETRAMETHYLPYRAZINE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research TETRAMETHYLPYRAZINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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