Tetramethylpyrazine
Tetramethylpyrazine is a member of the class of pyrazines that is pyrazine in which all four hydrogens have been replaced by methyl groups. An alkaloid extracted from Chuanxiong (Ligusticum wallichii). It has a role as an antineoplastic agent, a vasodilator agent, a platelet aggregation inhibitor, a neuroprotective agent, an apoptosis inhibitor and a bacterial metabolite. It is an alkaloid and a member of pyrazines. — ChEBI
- IUPAC name
- 2,3,5,6-tetramethylpyrazine
- Molecular formula
- C8H12N2
- Molecular weight
- 136.19 g/mol
- Exact mass
- 136.100048391 Da
- XLogP3
- 1.3
- Topological polar surface area
- 25.8 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 2
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:133246
- ChEMBL:CHEMBL303697
- EPA DTXSID:DTXSID6047070
- PubMed:23563941
- PubMed:23117466
- PubMed:23058057
- PubMed:22972787
- PubMed:22928823
- PubMed:22855036
- PubMed:22803382
- PubMed:22710373
- PubMed:22689424
- PubMed:22679731
- PubMed:22626794
- PubMed:22611379
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 190.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 190 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- LogP: 1.28 Source: Human Metabolome Database (HMDB)
- Melting Point: 86 °C Source: Human Metabolome Database (HMDB)
- Physical Description: Solid Source: Human Metabolome Database (HMDB)
- Physical Description: white crystals or powder with a musty, fermented, coffee odour Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: slightly soluble in water; soluble in oils, propylene glycol, organic solvents Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: very soluble (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: <0.1 [ug/mL] (The mean of the results at pH 7.4) Source: Sanford-Burnham Center for Chemical Genomics
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1685 reports by companies from 8 notifications to the ECHA C&L Inventory.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: NITE-CMC
- GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral] Source: NITE-CMC
- Precautionary Statement Codes: P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement) Source: NITE-CMC
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.