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InventoryRef 4013902/03/2011

HEXADEC-7-EN-16-OLIDE

Hexadec-7-en-16-olide

HEXADEC-7-EN-16-OLIDE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Chemical identity and properties

PubChem 2D chemical structure for CAS 123-69-3
CAS 123-69-3PubChem CID 5365703

Oxacycloheptadec-8-en-2-one, (8Z)-

(Z)-7-Hexadecen-1,16-olide is a macrolide. ChEBI

IUPAC name
(8Z)-1-oxacycloheptadec-8-en-2-one
Molecular formula
C16H28O2
Molecular weight
252.39 g/mol
Exact mass
252.208930132 Da
XLogP3
5.5
Topological polar surface area
26.3 Ų
Hydrogen-bond donors
0
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

AmbrettolideAmbrettolidNatural musk ambretteMusk(Z)-Oxacycloheptadec-8-en-2-one16-Hydroxy-7-hexadecenoic acid lactoneOXACYCLOHEPTADEC-8-EN-2-ONE, (Z)-095I377U8F
16 more reported names
RefChem:85700716-hydroxy-7-hexadecenoic acid, omicron-lactone204-644-5Musk naturalMusk ambrette (natural)Hexadec-7-en-16-olideOxacycloheptadec-8-en-2-one(Z)-7-Hexadecen-1,16-olideMusk ambrette, natural(Z)-7-Hexadecen-16-olide(8Z)-Oxacycloheptadec-8-en-2-oneEINECS 204-644-5AI3-30957UNII-095I377U8FOxacycloheptadec-7-en-2-one; 1-Oxa-7-cycloheptadecen-2-one; 16-Hydroxy-6-hexadecenoic Acid Lactone; 16-Hydroxy-6-hexadecenoic Acid ?-Lactone7-Hexadecen-16-olid
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match5365703

Attributed physical-property, hazard, environmental and use annotations.

  • Note: This chemical does not meet GHS hazard criteria for 19% (28 of 147) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H315 (73.5%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (73.5%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (73.5%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 147 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 28 of 147 reports by companies.; There are 4 notifications provided by 119 of 147 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for HEXADEC-7-EN-16-OLIDE

INCI name

HEXADEC-7-EN-16-OLIDE

Description

Hexadec-7-en-16-olide

Record provenance

Inventory reference
40139
Imported identity
HEXADEC-7-EN-16-OLIDE
Source update
02/03/2011
European Commission CosIng source notes

Key data

Restriction
Function
PERFUMING
Used for perfume and aromatic raw materials.

Ingredients with overlapping formulation functions

Additional official and scientific sources

11 external databases to check this identity in

How HEXADEC-7-EN-16-OLIDE appears in the CosIng inventory

The CosIng inventory lists HEXADEC-7-EN-16-OLIDE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

HEXADEC-7-EN-16-OLIDE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

HEXADEC-7-EN-16-OLIDE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, HEXADEC-7-EN-16-OLIDE carries the following function designation(s):

CAS 123-69-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Source note for HEXADEC-7-EN-16-OLIDE

This page reproduces the CosIng inventory entry for HEXADEC-7-EN-16-OLIDE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research HEXADEC-7-EN-16-OLIDE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

Tools & next steps

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