Is CIVETONE safe to use in EU cosmetics?

CIVETONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 542-46-1?

CAS 542-46-1 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains CIVETONE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3937002/03/2011

CIVETONE

(Z)-9-Cycloheptadecen-1-one

CIVETONE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 542-46-1

CAS 542-46-1PubChem CID 5315941

Civetone

Civetone is a macrocycle that is cycloheptadecanone with an unsaturation at position 9 (the 9Z-stereoisomer). It has been found in African Civets. It has a role as a pheromone, a fragrance and an animal metabolite. It is a cyclic ketone and a macrocycle. — ChEBI

IUPAC name: (9Z)-cycloheptadec-9-en-1-one

Molecular formula: C17H30O
Molecular weight: 250.4 g/mol
Exact mass: 250.229665576 Da
XLogP3: 6.1
Topological polar surface area: 17.1 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 1
Covalent units: 1
Defined stereocentres: 0

Also known as

cis-Civetone9-Cycloheptadecen-1-one, (9Z)-FEMA No. 3425cycloheptadeca-9-en-1-oneP0K30CV1UECIVETTONECHEBI:78317RefChem:126616

16 more reported names

208-813-4(Z)-Cycloheptadec-9-enone9-Cycloheptadecen-1-one, (Z)-NSC 90305cycloheptadec-9-en-1-oneCivettone, alpha-trans-9-Cycloheptadecen-1-one, cis-cis-9-Cycloheptadecen-1-oneEINECS 208-813-4UNII-P0K30CV1UEBRN 1954923AI3-38745(9Z)-9-CYCLOHEPTADECENE-1-ONECIVETONE [MI]3-07-00-00524 (Beilstein Handbook Reference)NSC-90305

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:78317
EPA DTXSID:DTXSID80883434
PubMed:18918792

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for CIVETONE

INCI name

CIVETONE

Description

(Z)-9-Cycloheptadecen-1-one

Record provenance

Inventory reference: 39370
Imported identity: CIVETONE
Source update: 02/03/2011

European Commission CosIng source notes

Annex records for CIVETONE

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Key data

CAS

542-46-1

208-813-4

Restriction

—

Function

PERFUMING: Used for perfume and aromatic raw materials.

Ingredients with overlapping formulation functions

CITRUS TUMIDA PEEL OILFRAGRANCE; PERFUMING

CITRUS UNSHIU/CITRUS RETICULATA/CITRUS IYO FRUIT WATERFRAGRANCE, PERFUMING

CITRYL ACETATEPERFUMING

CITRYL CYCLOPENTANONEPERFUMING

CNIDIUM OFFICINALE LEAFFLAVOURING, FRAGRANCE, PERFUMING, SKIN CONDITIONING

COCOS NUCIFERA LIQUID ENDOSPERMFRAGRANCE; SKIN CONDITIONING - MISCELLANEOUS; PERFUMING

COCOS NUCIFERA OILFRAGRANCE, HAIR CONDITIONING, PERFUMING, SKIN CONDITIONING

COFFEA ARABICA SEED WATERANTIOXIDANT; FRAGRANCE; PERFUMING; SKIN CONDITIONING - HUMECTANT

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How CIVETONE appears in the CosIng inventory

The CosIng inventory lists CIVETONE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

CIVETONE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

CIVETONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, CIVETONE carries the following function designation(s):

PERFUMING

CAS 542-46-1 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for CIVETONE

This page reproduces the CosIng inventory entry for CIVETONE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research CIVETONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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