InventoryRef 3926402/03/2011
DIPROPYL KETONE
Heptan-4-one
DIPROPYL KETONE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
No rule for this ingredient has been imported for any of the 13 markets tracked here.
That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.
Chemical identity and properties
CAS 123-19-3PubChem CID 31246
4-Heptanone
4-heptanone is a dialkyl ketone that is heptane in which the two methylene protons at position 4 have been replaced by an oxo group. It has a role as a biomarker, a human xenobiotic metabolite, a human urinary metabolite and a rat metabolite. It derives from a hydride of a heptane. — ChEBI
- IUPAC name
- heptan-4-one
- Molecular formula
- C7H14O
- Molecular weight
- 114.19 g/mol
- Exact mass
- 114.104465066 Da
- XLogP3
- 1.6
- Topological polar surface area
- 17.1 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 1
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
Dipropyl ketoneButyronePropyl ketoneDi-n-propyl ketone4-OxoheptaneFEMA No. 25469BN582JQ61NSC-8692
16 more reported names
CHEBI:89484RefChem:99080204-608-9NSC 86924-Heptanone (natural)EINECS 204-608-9UN2710BRN 1699049dipropylketondipropylketoneUNII-9BN582JQ61AI3-15181HSDB 7908heptane-4-one4-Heptanone, 98%4-HEPTANONE [FHFI]
External database identifiers
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match31246
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: 430 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 291 °F at 760 mmHg (NIOSH, 2024) Source: CAMEO Chemicals
- Boiling Point: 144 °C Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 144.00 to 145.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 144-146 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 144-145 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Boiling Point: 291 °F Source: Occupational Safety and Health Administration (OSHA)
- Boiling Point: 144 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
- Boiling Point: 291 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- Color/Form: Stable, colorless liquid Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.82 (NIOSH, 2024) - Less dense than water; will float Source: CAMEO Chemicals
- Density: 0.8174 g/cu cm at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: Bulk density: 6.79 lb/gal at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: Relative density (water = 1): 0.8 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Density: 0.814-0.817 (20 °C) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Density: 0.82 Source: Occupational Safety and Health Administration (OSHA)
- Density: 0.815 @25 °C Source: PAC Chemical Database, U.S. Department of Energy
- Density: 0.82 Source: The National Institute for Occupational Safety and Health (NIOSH)
- Flash Point: 120 °F (NIOSH, 2024) Source: CAMEO Chemicals
- Flash Point: 120 °F Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Flash Point: 48.89 °C (closed cup) Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 49 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Flash Point: 120 °F Source: Occupational Safety and Health Administration (OSHA)
- Flash Point: 120 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- LogP: log Kow = 2.04 Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -27 °F (NIOSH, 2024) Source: CAMEO Chemicals
- Melting Point: -33 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -34 °C Source: Human Metabolome Database (HMDB)
- Melting Point: -33 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -27 °F Source: Occupational Safety and Health Administration (OSHA)
- Melting Point: -32.6 °C Source: PAC Chemical Database, U.S. Department of Energy
- Melting Point: -27 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- Odor: Pleasant odor Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Dipropyl ketone appears as a colorless liquid with a pleasant odor. Insoluble in water and less dense than water. Flash point 120 °F. Toxic by inhalation. A skin irritant. Used to make flavorings and as a solvent. Source: CAMEO Chemicals
- Physical Description: Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Colorless liquid with a pleasant odor; [NIOSH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Liquid Source: Human Metabolome Database (HMDB)
- Physical Description: COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Physical Description: colourless liquid with a pungent, powerful, ethereal, fruity odour Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Physical Description: Colorless liquid with a pleasant odor. Source: Occupational Safety and Health Administration (OSHA)
- Physical Description: Colorless liquid with a pleasant odor. Source: The National Institute for Occupational Safety and Health (NIOSH)
- Refractive Index: Index of refraction = 1.4069 at 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Refractive Index: Very refractive Source: Hazardous Substances Data Bank (HSDB)
- Refractive Index: 1.403-1.409 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: Insoluble (NIOSH, 2024) Source: CAMEO Chemicals
- Solubility: Miscible with ethanol, ethyl ether; very soluble in ligroin Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in carbon tetrachloride Source: Hazardous Substances Data Bank (HSDB)
- Solubility: In water, 3.19X10+3 mg/L at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 3.2 mg/mL at 25 °C Source: Human Metabolome Database (HMDB)
- Solubility: Solubility in water at 20 °C: very poor Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Solubility: insoluble in water; soluble in alcohol and ether Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: Insoluble Source: The National Institute for Occupational Safety and Health (NIOSH)
- Vapor Pressure: 5 mmHg (NIOSH, 2024) Source: CAMEO Chemicals
- Vapor Pressure: 5.2 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 5.2 mm Hg at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: Vapor pressure, kPa at 20 °C: 0.7 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Vapor Pressure: 5 mmHg Source: Occupational Safety and Health Administration (OSHA)
- Vapor Pressure: 5.2 [mm Hg] @20 °C Source: PAC Chemical Database, U.S. Department of Energy
- Vapor Pressure: 5 mmHg Source: The National Institute for Occupational Safety and Health (NIOSH)
- Viscosity: 0.0074 cP at 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Exposure Routes: The substance can be absorbed into the body by inhalation of its vapour and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Exposure Routes: inhalation, ingestion, skin and/or eye contact Source: The National Institute for Occupational Safety and Health (NIOSH)
- First Aid: Excerpt from NIOSH Pocket Guide for Dipropyl ketone:; Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: SOAP WASH - If this chemical contacts the skin, wash the contaminated skin with soap and water.; Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.; Swallow: MEDICAL ATTENTION IMMEDIATELY - If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2024) Source: CAMEO Chemicals
- ERG2024, Guide 128 (Dipropyl ketone): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Soap wash - If this chemical contacts the skin, wash the contaminated skin with soap and water.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
- Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P317, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Note: This chemical does not meet GHS hazard criteria for < 0.1% (1 of 1945) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H226 (> 99.9%): Flammable liquid and vapor [Warning Flammable liquids]; H332 (> 99.9%): Harmful if inhaled [Warning Acute toxicity, inhalation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P317, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 1945 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 1 of 1945 reports by companies.; There are 3 notifications provided by 1944 of 1945 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: NITE-CMC
- GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: NITE-CMC
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264+P265, P271, P280, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P337+P317, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H303: May be harmful if swallowed [Warning Acute toxicity, oral]; H305: May be harmful if swallowed and enters airways [Warning Aspiration hazard]; H313: May be harmful in contact with skin [Warning Acute toxicity, dermal]; H316: Causes mild skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: NITE-CMC
- NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
- Target Organs: Eyes, skin, central nervous system, liver Source: The National Institute for Occupational Safety and Health (NIOSH)
- Environmental Bioconcentration: An estimated BCF of 9.7 was calculated in fish for dipropyl ketone(SRC), using a log Kow of 2.04(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 178(SRC), determined from a log Kow of 2.04(2) and a regression-derived equation(3), indicates that dipropyl ketone is expected to have moderate mobility in soil(SRC). Volatilization of dipropyl ketone from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.4X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 5.2 mm Hg at 20 °C(4), and water solubility, 3.19X10+3 mg/L (5). Dipropyl ketone is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(4). Limited biodegradation data are available for dipropyl ketone(SRC, 2011); however, as a group n-alkyl ketones are reported to be susceptible to microbial degradation(6). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 178(SRC), determined from a log Kow of 2.04(2) and a regression-derived equation(3), indicates that dipropyl ketone is expected to adsorb very little to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(4) based upon an estimated Henry's Law constant of 2.4X10-4 atm-cu m/mole(SRC), derived from its vapor pressure, 5.2 mm Hg at 20 °C(5), and water soubility, 3.19X10+3 mg/L(6). Using this Henry's Law constant and an estimation method(4), volatilization half-lives for a model river and model lake are 3.7 hours and 5.4 days, respectively(SRC). According to a classification scheme(7),an estimated BCF of 9.7(SRC), from its log Kow(2) and a regression-derived equation(3), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Limited biodegradation data are available for dipropyl ketone(SRC, 2011); however, as a group n-alkyl ketones are reported to be susceptible to microbial degradation(8). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dipropyl ketone, which has a vapor pressure of 5.2 mm Hg at 20 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase dipropyl ketone is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 1.7 days(SRC), calculated from its rate constant of 9.3X10-12 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). The maximum UV absorption of dipropyl ketone occurs near 280 nm(4), and the absorption spectrum is expected to extend beyond 290 nm; therefore, this substance may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Not Known or Reasonably Ascertainable Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Not Known or Reasonably Ascertainable Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used as a solvent for organic chemicals and surface coatings; [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Painting (Solvents) [Category: Paint] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Solvent for nitrocellulose, raw and blown oils, resins, and polymers; lacquers; flavoring. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for DIPROPYL KETONE
INCI name
DIPROPYL KETONE
Description
Heptan-4-one
Record provenance
- Inventory reference
- 39264
- Imported identity
- DIPROPYL KETONE
- Source update
- 02/03/2011
Annex records for DIPROPYL KETONE
Key data
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal
How DIPROPYL KETONE appears in the CosIng inventory
The CosIng inventory lists DIPROPYL KETONE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
DIPROPYL KETONE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
DIPROPYL KETONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.
According to the EU CosIng inventory, DIPROPYL KETONE carries the following function designation(s):
CAS 123-19-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
Source note for DIPROPYL KETONE
This page reproduces the CosIng inventory entry for DIPROPYL KETONE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research DIPROPYL KETONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
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