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CAS 58-55-9 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 3857815/10/2010

THEOPHYLLINE

1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-

THEOPHYLLINE is linked to 1 EU annex record on this page.

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Regulatory evidence by market

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Market	Evidence status	Records	Source language
European Union	Evidence linked Prohibited entry found Open this evidence	1	English and EU languages
Great Britain	Evidence linked Prohibited Open this evidence	1	English
Canada	Evidence linked Prohibited Open this evidence	1	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Evidence linked Prohibited Open this evidence	1	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Evidence linked Prohibited Open this evidence	1	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 58-55-9

CAS 58-55-9PubChem CID 2153

Theophylline

Theophylline is a dimethylxanthine having the two methyl groups located at positions 1 and 3. It is structurally similar to caffeine and is found in green and black tea. It has a role as a bronchodilator agent, a vasodilator agent, a drug metabolite, an anti-asthmatic drug, an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor, an immunomodulator, a muscle relaxant, an anti-inflammatory agent, an adenosine receptor antagonist, a fungal metabolite and a human blood serum metabolite. — ChEBI

IUPAC name: 1,3-dimethyl-7H-purine-2,6-dione

Molecular formula: C7H8N4O2
Molecular weight: 180.16 g/mol
Exact mass: 180.06472551 Da
XLogP3: 0.0
Topological polar surface area: 69.3 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

1,3-DimethylxanthineElixophyllinTheophyllinTheolairNuelinTheophylline anhydrousElixophyllineLanophyllin

16 more reported names

PseudotheophyllineRespbidSolosinTheocinTheo-durLiquophyllineOptiphyllinParkophyllinTheofolTheogradAcet-theocinSlo-phyllinArmophyllineSlo-bidDoraphyllinElixicon

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:28177
ChEMBL:CHEMBL190
EPA DTXSID:DTXSID5021336
PubMed:32020584
PubMed:23124564
PubMed:23123723
PubMed:23118686
PubMed:23109210
PubMed:23107752
PubMed:23091500
PubMed:23082076
PubMed:23062978
PubMed:23055863
PubMed:23023414
PubMed:23011860

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for THEOPHYLLINE

INCI name

THEOPHYLLINE

INN name

theophylline

Ph. Eur. name

theophyllinum

Description

1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-

Record provenance

Inventory reference: 38578
Imported identity: THEOPHYLLINE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for THEOPHYLLINE

Annex II Shared CAS number

Entry 1710

Theophylline; 1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

CAS: 58-55-9

EC: 200-385-7

Key data

CAS

58-55-9

200-385-7

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.
TONIC: Producing a feeling of well-being on skin and hair.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#28737 · THEOPHYLLINE

Ingredients with overlapping formulation functions

SISYMBRIUM IRIO SEED OILFRAGRANCE, TONIC

SMILAX MEDICA ROOT EXTRACTTONIC

SPIRAEA ULMARIA EXTRACTASTRINGENT, SKIN CONDITIONING, TONIC

SYRINGA VULGARIS EXTRACTSKIN CONDITIONING, TONIC

THUJA OCCIDENTALIS LEAF OILFRAGRANCE, PERFUMING, TONIC

THYMUS VULGARIS FLOWER/LEAF EXTRACTFRAGRANCE, SKIN CONDITIONING, TONIC

THYMUS VULGARIS FLOWER/LEAF OILFRAGRANCE, SKIN CONDITIONING, TONIC

TILIA CORDATA FLOWER WATERFRAGRANCE, SKIN CONDITIONING, TONIC

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How THEOPHYLLINE appears in the CosIng inventory

The CosIng inventory lists THEOPHYLLINE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

THEOPHYLLINE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

THEOPHYLLINE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

According to the EU CosIng inventory, THEOPHYLLINE carries the following function designation(s):

CAS 58-55-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for THEOPHYLLINE

This page combines the CosIng inventory entry for THEOPHYLLINE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research THEOPHYLLINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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