Is NEORUSCOGENIN safe to use in EU cosmetics?

NEORUSCOGENIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 17676-33-4?

CAS 17676-33-4 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 3549315/10/2010

NEORUSCOGENIN

Spirosta-5,25(27)-diene-1.beta.,3.beta.-diol

NEORUSCOGENIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 17676-33-4

CAS 17676-33-4PubChem CID 9910474

Neoruscogenin

(1S,2S,4S,6R,7S,8R,9S,12S,13R,14R,16R)-7,9,13-trimethyl-5'-methylidenespiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-14,16-diol has been reported in Helleborus orientalis with data available. — LOTUS - the natural products occurrence database

IUPAC name: (1S,2S,4S,6R,7S,8R,9S,12S,13R,14R,16R)-7,9,13-trimethyl-5'-methylidenespiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-14,16-diol

Molecular formula: C27H40O4
Molecular weight: 428.6 g/mol
Exact mass: 428.29265975 Da
XLogP3: 4.1
Topological polar surface area: 58.9 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 11

Also known as

25(27)-DehydroruscogeninSpirosta-5,25(27)-diene-1beta,3beta-diolD4E4KC2TUKSpirosta-5,25(27)-diene-1,3-diol, (1beta,3beta)-(1S,2S,4S,6R,7S,8R,9S,12S,13R,14R,16R)-7,9,13-trimethyl-5'-methylidenespiro(5-oxapentacyclo(10.8.0.02,9.04,8.013,18)icos-18-ene-6,2'-oxane)-14,16-diolRefChem:8323491 beta,3 beta,25S-spirosta-5,25(27)-diene-1,3-diol241-660-1

16 more reported names

delta5-ConvallamarogeninC27H40O4Spirosta-5,25(27)-dien-1beta,3beta-diol(1beta,3beta)-Spirosta-5,25(27)-diene-1,3-diolSpirosta-5,25(27)-diene-1?,3?-diol; (1?,3?)-Spirosta-5,25(27)-diene-1,3-diol; 25(27)-Dehydroruscogenin;EINECS 241-660-1Spirosta-5,25(27)-diene-1,3-diol, (1b,3b)-Neoruscogenin (Standard)UNII-D4E4KC2TUKHY-N2253RALTRINCJVPIQNK-NHIXJPGBSA-NCHEBI:228892Spirosta-5,25(27)-diene-1,3-diol, (1.beta.,3.beta.)-HY-N2253EBC-616268T3S1251

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:228892
PubMed:23499166
PubMed:5387

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for NEORUSCOGENIN

INCI name

NEORUSCOGENIN

Description

Spirosta-5,25(27)-diene-1.beta.,3.beta.-diol

Record provenance

Inventory reference: 35493
Imported identity: NEORUSCOGENIN
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for NEORUSCOGENIN

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Key data

CAS

17676-33-4

241-660-1

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#17348 · NEORUSCOGENIN

Ingredients with overlapping formulation functions

NEOPENTYL GLYCOL DIHEPTANOATESKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

NEOPENTYL GLYCOL DIISOSTEARATESKIN CONDITIONING, SURFACTANT - EMULSIFYING

NEOPENTYL GLYCOL DILAURATESKIN CONDITIONING, SURFACTANT - EMULSIFYING

NEOPENTYL GLYCOL DIPELARGONATEPLASTICISER, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SOLVENT

NEPENTHES MIRABILIS PITCHER EXTRACTHUMECTANT, SKIN CONDITIONING

NEPETA CATARIA WATERSKIN CONDITIONING

NEPETA SIBIRICA FLOWER/LEAF/STEM EXTRACTHAIR CONDITIONING, HUMECTANT, SKIN CONDITIONING

NEPHELIUM LAPPACEUM BRANCH/FRUIT/LEAF EXTRACTSKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How NEORUSCOGENIN appears in the CosIng inventory

The CosIng inventory lists NEORUSCOGENIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

NEORUSCOGENIN is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

NEORUSCOGENIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, NEORUSCOGENIN carries the following function designation(s):

SKIN CONDITIONING

CAS 17676-33-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for NEORUSCOGENIN

This page reproduces the CosIng inventory entry for NEORUSCOGENIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research NEORUSCOGENIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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