What does the restriction note for METHYL THIOGLYCOLATE mean?

The restriction field for METHYL THIOGLYCOLATE reads: III/2b. This is the restriction note from the CosIng inventory. For authoritative conditions and limits, always refer to the linked annex entries.

What other records share CAS 2365-48-2?

CAS 2365-48-2 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains METHYL THIOGLYCOLATE?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3532815/10/2010

METHYL THIOGLYCOLATE

Methyl mercaptoacetate

METHYL THIOGLYCOLATE is linked to 1 EU annex record on this page. Inventory note: III/2b.

INCI Checker Compare all markets Search similar

Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

Compare markets

Swipe or scroll horizontally to see every column.

Market	Evidence status	Records	Source language
European Union	Evidence linked Restricted entry found Open this evidence	1	English and EU languages
Great Britain	Source mapped Official source mapped; ingredient rule not imported	0	English
Canada	Source mapped Official source mapped; ingredient rule not imported	0	English and French
New Zealand	Source mapped Official source mapped; ingredient rule not imported	0	English
ASEAN	Source mapped Official source mapped; ingredient rule not imported	0	English and national languages
China	Source mapped Official source mapped; ingredient rule not imported	0	Chinese with selected English material
Japan	Source mapped Official source mapped; ingredient rule not imported	0	Japanese; official English translation available
South Korea	Source mapped Official source mapped; ingredient rule not imported	0	Korean with some English names
United States	Source mapped Official source mapped; ingredient rule not imported	0	English
Australia	Source mapped Official source mapped; ingredient rule not imported	0	English
Brazil	Source mapped Official source mapped; ingredient rule not imported	0	Portuguese with INCI crosswalks
India	Source mapped Official source mapped; ingredient rule not imported	0	English and Hindi
Saudi Arabia	Source mapped Official source mapped; ingredient rule not imported	0	Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 2365-48-2

CAS 2365-48-2PubChem CID 16907

Methyl Thioglycolate

Based on the available data, the CIR Expert Panel concluded that ... Methyl Thioglycolate is safe for use in hair straighteners, permanent waves, tonics, dressings, and so forth, wave sets, other non-coloring hair products, and hair dyes and colors, as described in this safety assessment, at concentrations up to 15.2% (as Thioglycolic Acid). Hairdressers should avoid skin contact and minimize consumer skin exposure. — Cosmetic Ingredient Review (CIR)

IUPAC name: methyl 2-sulfanylacetate

Molecular formula: C3H6O2S
Molecular weight: 106.15 g/mol
Exact mass: 106.00885060 Da
XLogP3: 0.4
Topological polar surface area: 27.3 Å²
Hydrogen-bond donors: 1
Hydrogen-bond acceptors: 3
Covalent units: 1
Defined stereocentres: 0

Also known as

Methyl mercaptoacetateMethyl 2-mercaptoacetateThioglycolic acid methyl esterMethylthioglycolateAcetic acid, mercapto-, methyl esterMethanethiol, methoxy-MethylmercaptoacetateUSAF EK-7119

16 more reported names

Acetic acid, 2-mercapto-, methyl esterO1608LA9ELNSC-75117RefChem:818100219-121-7Mercaptoacetic acid methyl esterMethyl sulfanylacetate2-mercaptoacetic acid methyl esterThioglykolsaeure-methylesterNSC 75117Methyl .alpha.-mercaptoacetatemercapto-acetic acid methyl esterHSDB 2705EINECS 219-121-7Thioglykolsaeure-methylester [German]BRN 0506259

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEMBL:CHEMBL1341329
EPA DTXSID:DTXSID0033673
PubMed:33358762
PubMed:22679373
PubMed:21625716
PubMed:21332185
PubMed:20828158
PubMed:20598143
PubMed:17007824
PubMed:16146387
PubMed:15710507

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for METHYL THIOGLYCOLATE

INCI name

METHYL THIOGLYCOLATE

Description

Methyl mercaptoacetate

Record provenance

Inventory reference: 35328
Imported identity: METHYL THIOGLYCOLATE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for METHYL THIOGLYCOLATE

Annex III Restriction reference

Entry 2b

Thioglycolic acid esters

Key data

CAS

2365-48-2

219-121-7

Restriction

III/2b

Function

HAIR WAVING OR STRAIGHTENING: Modifying the chemical structure of the hair, allowing it to be set in the style required (permanent waves or hair straightening).

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#16578 · METHYL THIOGLYCOLATE

Ingredients with overlapping formulation functions

MEA-THIOLACTATEHAIR WAVING OR STRAIGHTENING

MERCAPTOPROPIONIC ACIDDEPILATORY, HAIR WAVING OR STRAIGHTENING, REDUCING

METHACRYLOYL HYDROLYZED SOY PROTEINANTIOXIDANT, HAIR CONDITIONING, HAIR WAVING OR STRAIGHTENING, SKIN CONDITIONING, SKIN PROTECTING

METHOXY PEG-450 AMIDOGLUTAROYL SUCCINIMIDECLEANSING, HAIR CONDITIONING, HAIR WAVING OR STRAIGHTENING

MYRISTOYL PULLULANFILM FORMING, HAIR FIXING, HAIR WAVING OR STRAIGHTENING

OLEUROPEINANTIOXIDANT, HAIR CONDITIONING, HAIR FIXING, HAIR WAVING OR STRAIGHTENING

POLY(LINSEED OIL)BINDING, FILM FORMING, HAIR CONDITIONING, HAIR FIXING, HAIR WAVING OR STRAIGHTENING, VISCOSITY CONT…

POLYCITRONELLOL ACETATEFRAGRANCE, HAIR CONDITIONING, HAIR WAVING OR STRAIGHTENING, HUMECTANT, SKIN CONDITIONING - EMOLLIEN…

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How METHYL THIOGLYCOLATE appears in the CosIng inventory

The CosIng inventory lists METHYL THIOGLYCOLATE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

METHYL THIOGLYCOLATE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

METHYL THIOGLYCOLATE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for METHYL THIOGLYCOLATE reads: "III/2b". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, METHYL THIOGLYCOLATE carries the following function designation(s):

HAIR WAVING OR STRAIGHTENING

CAS 2365-48-2 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Open INCI Checker

Source note for METHYL THIOGLYCOLATE

This page combines the CosIng inventory entry for METHYL THIOGLYCOLATE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research METHYL THIOGLYCOLATE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sources View updates

Tools & next steps

Check your formula

Scan a full INCI list to detect METHYL THIOGLYCOLATE and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to METHYL THIOGLYCOLATE, its identifiers or nearby name variants.