Is MENADIONE safe to use in EU cosmetics?

MENADIONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 58-27-5?

CAS 58-27-5 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3521415/10/2010

MENADIONE

1,4-Naphthalenedione, 2-methyl-; Vitamin K3

MENADIONE is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 58-27-5

CAS 58-27-5PubChem CID 4055

Menadione

Menadione is a member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia. It has a role as an EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor, an antineoplastic agent, an angiogenesis inhibitor, a nutraceutical and a human urinary metabolite. It is a member of 1,4-naphthoquinones and a vitamin K. — ChEBI

IUPAC name: 2-methylnaphthalene-1,4-dione

Molecular formula: C11H8O2
Molecular weight: 172.18 g/mol
Exact mass: 172.052429494 Da
XLogP3: 2.2
Topological polar surface area: 34.1 Å²
Hydrogen-bond donors: 0
Hydrogen-bond acceptors: 2
Covalent units: 1
Defined stereocentres: 0

Also known as

Vitamin K32-Methyl-1,4-naphthoquinoneKayquinoneMenaphthoneThyloquinoneKanoneKappaxinKayklot

16 more reported names

KlottonePanosine2-Methyl-1,4-naphthalenedioneKolklot2-MethylnaphthoquinoneKareonKoaxinKipcaAquinoneKaergonaMenadionMenaphthonProkayvitAquakaySynkayKativ-G

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:28869
ChEMBL:CHEMBL590
EPA DTXSID:DTXSID4021715
PubMed:27558805
PubMed:24318724
PubMed:23081798
PubMed:23039745
PubMed:22999172
PubMed:22956199
PubMed:22910835
PubMed:22891633
PubMed:22878737
PubMed:22863063
PubMed:22821789
PubMed:22805759

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for MENADIONE

INCI name

MENADIONE

INN name

menadione

Description

1,4-Naphthalenedione, 2-methyl-; Vitamin K3

Record provenance

Inventory reference: 35214
Imported identity: MENADIONE
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for MENADIONE

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Key data

CAS

58-27-5

200-372-6

Restriction

—

Function

FRAGRANCE: Imparting an odour or taste. Creating a perceivable pleasant smell and/or masking a bad smell.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#16178 · MENADIONE

Ingredients with overlapping formulation functions

MELILOTUS OFFICINALIS EXTRACTASTRINGENT, FRAGRANCE, SOOTHING

MELISSA OFFICINALIS FLOWER/LEAF/STEM OILFLAVOURING, FRAGRANCE, SKIN CONDITIONING

MELISSA OFFICINALIS LEAF OILFRAGRANCE, PERFUMING, TONIC

MELISSA OFFICINALIS LEAF/STEM OILFRAGRANCE, SKIN CONDITIONING - MISCELLANEOUS

MENTHA AQUATICA FLOWER/LEAF/STEM OILFLAVOURING, FRAGRANCE

MENTHA AQUATICA FLOWER/LEAF/STEM WATERFRAGRANCE

MENTHA AQUATICA LEAF OILFRAGRANCE, SKIN CONDITIONING

MENTHA ARVENSIS EXTRACTFRAGRANCE, REFRESHING, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How MENADIONE appears in the CosIng inventory

The CosIng inventory lists MENADIONE as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

MENADIONE is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

MENADIONE is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, MENADIONE carries the following function designation(s):

FRAGRANCE

CAS 58-27-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for MENADIONE

This page reproduces the CosIng inventory entry for MENADIONE from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research MENADIONE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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