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InventoryRef 3459621/11/2016

ISOAMYL ALCOHOL

3-Methylbutan-1-ol

ISOAMYL ALCOHOL is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 123-51-3
CAS 123-51-3PubChem CID 31260

Isoamyl Alcohol

Isoamylol is an primary alcohol that is butan-1-ol in which a hydrogen at position 3 has been replaced by a methyl group. It has a role as an antifungal agent, a Saccharomyces cerevisiae metabolite and a xenobiotic metabolite. It is a volatile organic compound, a primary alcohol and an alkyl alcohol. It derives from a hydride of an isopentane. — ChEBI

IUPAC name
3-methylbutan-1-ol
Molecular formula
C5H12O
Molecular weight
88.15 g/mol
Exact mass
88.088815002 Da
XLogP3
1.2
Topological polar surface area
20.2 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
1
Covalent units
1
Defined stereocentres
0

Also known as

3-Methyl-1-butanolIsopentyl alcoholIsopentanol3-Methylbutanol1-Butanol, 3-methyl-IsoamylolIsobutylcarbinol2-Methyl-4-butanol
16 more reported names
Isobutyl carbinolIso-amylalkoholISOAMYLALCOHOLAlcool isoamyliqueAmylowy alkoholIsoamyl alkoholAlcool amilicoFermentation amyl alcohol3-Metil-butanoloPrimary isoamyl alcohol3-methyl butanolFEMA No. 2057FEMA Number 2057DEM9NIT1J4NSC-1029NSC-7905
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match31260

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: Excerpt from NIOSH Pocket Guide for Isoamyl alcohol (primary):; Eye: IRRIGATE IMMEDIATELY - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: WATER FLUSH PROMPTLY - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.; Breathing: RESPIRATORY SUPPORT - If a person breathes large amounts of this chemical, move the exposed person to fresh air at once. If breathing has stopped, perform artificial respiration. Keep the affected person warm and at rest. Get medical attention as soon as possible.; Swallow: MEDICAL ATTENTION IMMEDIATELY - If this chemical has been swallowed, get medical attention immediately. (NIOSH, 2024) Source: CAMEO Chemicals
  • First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H226 (99.2%): Flammable liquid and vapor [Warning Flammable liquids]; H302 (17.7%): Harmful if swallowed [Warning Acute toxicity, oral]; H315 (69.5%): Causes skin irritation [Warning Skin corrosion/irritation]; H318 (10.3%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H319 (70.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332 (80.5%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (82.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 2589 reports by companies from 47 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Warning Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H226 (52.2%): Flammable liquid and vapor [Warning Flammable liquids]; H315 (47.8%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (47.8%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 115 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects] Source: NITE-CMC
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P303+P361+P353, P304+P340, P305+P354+P338, P317, P319, P330, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H303: May be harmful if swallowed [Warning Acute toxicity, oral]; H313: May be harmful in contact with skin [Warning Acute toxicity, dermal]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure] Source: NITE-CMC
  • NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: The BCF for isopentanol estimated from isopentanol's octanol/water partition coefficient, log 1.42(1), using a recommended regression equation is 7(2). Such a low BCF would indicate that isopentanol would not bioconcentrate in aquatic organisms(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: In view of isopentanol's relatively high vapor pressure, 2.37 mm Hg at 25 °C(1), moderate Henry's Law constant, 1.41X10-5 atm-cu m/mol(2), and low adsorptivity to soil, isopentanol would be expected to volatilize from dry and moist soil(SRC). It is highly mobile in soil and should leach. Isopentanol is readily biodegraded in screening tests as well as in water grab sample tests and therefore would be expected to biodegrade in soil. (SRC) Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: If released in water, isopentanol will be lost by volatilization. The volatilization half-life of isopentanol from a model river estimated from its Henry's Law constant, 1.41X10-5 atm-cu m/mol(1), is 2.55 days(2). It should also biodegrade. The half-life of isopentanol in groundwater, river water and Lake Superior harbor water in Minnesota were 15, 11, and 6.1 days, respectively(3). Isopentanol would not be expected to adsorb to sediment or bioconcentrate in aquatic organisms. Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: Isopentanol will react with photochemically-produced hydroxyl radicals in the atmosphere. The rate constant estimated for this reaction is 7.8X10-12 cu cm/molec-sec(1). Assuming a hydroxyl radical concn of 5X10+5 radicals/cu cm, the half-life of isopentanol in the atmosphere will be 2.0 days(SRC). Source: Hazardous Substances Data Bank (HSDB)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ISOAMYL ALCOHOL

INCI name

ISOAMYL ALCOHOL

Description

3-Methylbutan-1-ol

Record provenance

Inventory reference
34596
Imported identity
ISOAMYL ALCOHOL
Source update
21/11/2016
European Commission CosIng source notes
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Key data

CAS
123-51-3
EC
204-633-5
Restriction
—
Function
FLAVOURING
Imparting taste and/or flavour to a cosmetic product.
PERFUMING
Used for perfume and aromatic raw materials.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#13647 · ISOAMYL ALCOHOL

Ingredients with overlapping formulation functions

HYDROLYZED MALPIGHIA GLABRA FRUIT EXTRACTFLAVOURING, HUMECTANT
HYLOCEREUS UNDATUS FRUIT JUICEFLAVOURING, SKIN CONDITIONING
ILLICIUM VERUM LEAF OILFLAVOURING, FRAGRANCE, SKIN CONDITIONING
IRIS FLORENTINA FLOWER WATERFLAVOURING, FRAGRANCE, PERFUMING, SKIN CONDITIONING
ISOCARVYL ACETATEFLAVOURING
ISOEUGENOLFLAVOURING, PERFUMING
JASMINUM SAMBAC LEAF CELL EXTRACTFLAVOURING, FRAGRANCE, PERFUMING, SKIN PROTECTING
LAVANDULA ANGUSTIFOLIA FLOWER/LEAF/STEM EXTRACTFLAVOURING, FRAGRANCE, ORAL CARE, PERFUMING, SKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How ISOAMYL ALCOHOL appears in the CosIng inventory

The CosIng inventory lists ISOAMYL ALCOHOL as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ISOAMYL ALCOHOL is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ISOAMYL ALCOHOL is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ISOAMYL ALCOHOL carries the following function designation(s):

CAS 123-51-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for ISOAMYL ALCOHOL

This page reproduces the CosIng inventory entry for ISOAMYL ALCOHOL from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ISOAMYL ALCOHOL and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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