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InventoryRef 3417512/08/2020

GUANINE

Guanine (CI 75170)

GUANINE is linked to 1 EU annex record on this page. Inventory note: IV/113.

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Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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MarketEvidence statusRecordsSource language
European UnionEvidence linked
Positive-list entry with conditions
Open this evidence		1English and EU languages
Great BritainSource mapped
Official source mapped; ingredient rule not imported
0English
CanadaSource mapped
Official source mapped; ingredient rule not imported
0English and French
New ZealandSource mapped
Official source mapped; ingredient rule not imported
0English
ASEANSource mapped
Official source mapped; ingredient rule not imported
0English and national languages
ChinaSource mapped
Official source mapped; ingredient rule not imported
0Chinese with selected English material
JapanSource mapped
Official source mapped; ingredient rule not imported
0Japanese; official English translation available
South KoreaSource mapped
Official source mapped; ingredient rule not imported
0Korean with some English names
United StatesEvidence linked
Permitted list with conditions
Open this evidence		1English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilSource mapped
Official source mapped; ingredient rule not imported
0Portuguese with INCI crosswalks
IndiaSource mapped
Official source mapped; ingredient rule not imported
0English and Hindi
Saudi ArabiaSource mapped
Official source mapped; ingredient rule not imported
0Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 73-40-5
CAS 73-40-5PubChem CID 135398634

Guanine

Guanine is a 2-aminopurine carrying a 6-oxo substituent. It has a role as a mouse metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite, a human metabolite and an algal metabolite. It is a member of 2-aminopurines, an oxopurine and a purine nucleobase. It derives from a hydride of a 9H-purine. — ChEBI

IUPAC name
2-amino-1,7-dihydropurin-6-one
Molecular formula
C5H5N5O
Molecular weight
151.13 g/mol
Exact mass
151.04940980 Da
XLogP3
-1.1
Topological polar surface area
96.2 Ų
Hydrogen-bond donors
3
Hydrogen-bond acceptors
3
Covalent units
1
Defined stereocentres
0

Also known as

2-Amino-6-hydroxypurine2-AminohypoxanthineGuaninMearlmaidGuanine enolPearl essenceStella PolarisDew Pearl
16 more reported names
NaturonNatural white 1Natural pearl essence6H-Purin-6-one, 2-amino-1,7-dihydro-2-Amino-1,7-dihydro-6H-purin-6-oneCI Natural white 1C.I. Natural White 1Hypoxanthine, 2-amino-6-Hydroxy-2-aminopurineCI 751702-amino-3,7-dihydropurin-6-oneC.I. 75170CHEBI:162355Z93L87A1RC.i. no. 75170 (guanine)2-amino-6,9-dihydro-1H-purin-6-one
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for GUANINE

INCI name

GUANINE

Description

Guanine (CI 75170)

Record provenance

Inventory reference
34175
Imported identity
GUANINE
Source update
12/08/2020
European Commission CosIng source notes
Annex IV Restriction reference
Entry 113

CI 75170

CAS: 73-40-5
EC: 200-799-8

Key data

CAS
73-40-5
EC
200-799-8
Restriction
IV/113
Function
COLORANT
Exclusively or mainly intended to colour the cosmetic product, the body as a whole or certain parts thereof, by absorption or reflection of visible light. All authorised colorants are substances in the positive list of Annex IV to the Cosmetics Regulation 1223/2009.
OPACIFYING
Reducing transparency or translucency of cosmetics.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#11497 · GUANINE

Records sharing a CAS or EC identity

CI 75170

Ingredients with overlapping formulation functions

GLYCOL MONTANATEOPACIFYING, SKIN CONDITIONING, SURFACTANT - EMULSIFYING
GLYCOL PALMITATEOPACIFYING, SKIN CONDITIONING, SURFACTANT - EMULSIFYING
GLYCOL STEARATEOPACIFYING, SKIN CONDITIONING - EMOLLIENT, SURFACTANT - CLEANSING, SURFACTANT - EMULSIFYING
GOSSYPIUM HERBACEUM POWDERABSORBENT, OPACIFYING
GUANOSINEOPACIFYING, SKIN CONDITIONING
HEDTAABSORBENT, BULKING, CHELATING, OPACIFYING, VISCOSITY CONTROLLING
HELIANTHUS ANNUUS SEED BUTTEROPACIFYING, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT
HEMA/METHACRYLAMIDOPROPYLTRIMONIUM CHLORIDE/STYRENE COPOLYMEROPACIFYING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal

How GUANINE appears in the CosIng inventory

The CosIng inventory lists GUANINE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

GUANINE is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

GUANINE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for GUANINE reads: "IV/113". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, GUANINE carries the following function designation(s):

CAS 73-40-5 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
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Source note for GUANINE

This page combines the CosIng inventory entry for GUANINE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research GUANINE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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