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CAS 1405-86-3 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 3415615/10/2010

GLYCYRRHIZIC ACID

Glycyrrhizic acid

GLYCYRRHIZIC ACID is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 1405-86-3

CAS 1405-86-3PubChem CID 14982

Glycyrrhizin

Glycyrrhizinic acid is a triterpenoid saponin that is the glucosiduronide derivative of 3beta-hydroxy-11-oxoolean-12-en-30-oic acid. It has a role as an EC 3.4.21.5 (thrombin) inhibitor and a plant metabolite. It is a glucosiduronic acid, a pentacyclic triterpenoid, a tricarboxylic acid, an enone and a triterpenoid saponin. It is a conjugate acid of a glycyrrhizinate(3-). — ChEBI

IUPAC name: (2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid

Molecular formula: C42H62O16
Molecular weight: 822.9 g/mol
Exact mass: 822.40378589 Da
XLogP3: 3.7
Topological polar surface area: 267.0 Å²
Hydrogen-bond donors: 8
Hydrogen-bond acceptors: 16
Covalent units: 1
Defined stereocentres: 19

Also known as

Glycyrrhizic acidGlycyronGlycyrrhizinic acidpotenlinibeta-GlycyrrhizinGlycyrrhetinic acid glycosideGlizigen18beta-Glycyrrhizic acid

16 more reported names

glycyrrhizate18-beta-Glycyrrhizic acidGlycyrrizinRizinsan K2 A2 (free acid)HSDB 496NSC-167409NSC-234419CHEBI:15939EINECS 215-785-7NSC 167409NSC 234419UNII-6FO62043WKBRN 0077922CCRIS 84446FO62043WK20beta-Carboxy-11-oxo-30-norolean-12-en-3beta-yl-2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic acid

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:15939
ChEMBL:CHEMBL441687
EPA DTXSID:DTXSID8047006
PubMed:24963489
PubMed:24397541
PubMed:23678825
PubMed:23117432
PubMed:23105868
PubMed:23015817
PubMed:22982774
PubMed:22980806
PubMed:22980043
PubMed:22978213
PubMed:22972479
PubMed:22965701

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for GLYCYRRHIZIC ACID

INCI name

GLYCYRRHIZIC ACID

Description

Glycyrrhizic acid

Record provenance

Inventory reference: 34156
Imported identity: GLYCYRRHIZIC ACID
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for GLYCYRRHIZIC ACID

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Key data

CAS

1405-86-3

215-785-7

Restriction

—

Function

HUMECTANT: Retaining and/or preserving the moisture in a product during use.
SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#11379 · GLYCYRRHIZIC ACID

Ingredients with overlapping formulation functions

GLYCOLHUMECTANT, SOLVENT, VISCOSITY CONTROLLING

GLYCOLIDEHUMECTANT, SKIN CONDITIONING

GLYCYRRHETINIC GLUCURONIDEHUMECTANT; SKIN PROTECTING

GLYCYRRHETINYL STEARATEHUMECTANT, SKIN CONDITIONING

GOLD CHLORIDE HCLCOLORANT, HUMECTANT

GOSSYPIUM HERBACEUM FLOWER EXTRACTHUMECTANT, SKIN CONDITIONING

GRACILARIA CONFERTA POWDERASTRINGENT, FILM FORMING, HUMECTANT, SKIN CONDITIONING, VISCOSITY CONTROLLING

GRACILARIA VERRUCOSA EXTRACTHUMECTANT, SKIN PROTECTING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How GLYCYRRHIZIC ACID appears in the CosIng inventory

The CosIng inventory lists GLYCYRRHIZIC ACID as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

GLYCYRRHIZIC ACID is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

GLYCYRRHIZIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, GLYCYRRHIZIC ACID carries the following function designation(s):

CAS 1405-86-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for GLYCYRRHIZIC ACID

This page reproduces the CosIng inventory entry for GLYCYRRHIZIC ACID from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research GLYCYRRHIZIC ACID and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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