Is GLUCONIC ACID safe to use in EU cosmetics?

GLUCONIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 526-95-4?

CAS 526-95-4 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains GLUCONIC ACID?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3400821/11/2016

GLUCONIC ACID

D-gluconic acid

GLUCONIC ACID is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 526-95-4

CAS 526-95-4PubChem CID 10690

Gluconic Acid

D-gluconic acid is a gluconic acid having D-configuration. It has a role as a chelator and a Penicillium metabolite. It is a conjugate acid of a D-gluconate. It is an enantiomer of a L-gluconic acid. — ChEBI

IUPAC name: (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid

Molecular formula: C6H12O7
Molecular weight: 196.16 g/mol
Exact mass: 196.05830272 Da
XLogP3: -3.4
Topological polar surface area: 138.0 Å²
Hydrogen-bond donors: 6
Hydrogen-bond acceptors: 7
Covalent units: 1
Defined stereocentres: 4

Also known as

D-gluconic aciddextronic acidmaltonic acidGlycogenic acidGlosantoPentahydroxycaproic acidD-Gluco-hexonic acidR4R8J0Q44B

16 more reported names

INS NO.574CHEBI:33198INS-574E-574NSC-77381RefChem:5859GlyTouCan:G12678RQCHEBI:24266208-401-4Gluconic acid, D-Hexonic acidGluconic acid (VAN)133-42-6D-GluconsaeureD-GlukonsaeureBRN 1726055

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:33198
ChEMBL:CHEMBL464345
EPA DTXSID:DTXSID8027169
EPA DTXSID:DTXSID8042000
PubMed:23112480
PubMed:23107720
PubMed:23090569
PubMed:23049364
PubMed:23041806
PubMed:23035442
PubMed:23010832
PubMed:22995299
PubMed:22986198
PubMed:22978361
PubMed:22974967
PubMed:22962927

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for GLUCONIC ACID

INCI name

GLUCONIC ACID

Description

D-gluconic acid

Record provenance

Inventory reference: 34008
Imported identity: GLUCONIC ACID
Source update: 21/11/2016

European Commission CosIng source notes

Annex records for GLUCONIC ACID

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Key data

CAS

526-95-4

208-401-4

Restriction

—

Function

CHELATING: Forming complexes with metal ions which could affect the stability and/or appearance of cosmetics.
PERFUMING: Used for perfume and aromatic raw materials.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#11008 · GLUCONIC ACID

Ingredients with overlapping formulation functions

ETIDRONIC ACIDCHELATING

GALACTARIC ACIDCHELATING

GALACTURONIC ACIDBUFFERING, CHELATING, HUMECTANT

GALLOYL TRIPEPTIDE-35ANTIOXIDANT, CHELATING, SKIN PROTECTING

GLUCONOLACTONECHELATING, SKIN CONDITIONING

GLUCURONIC ACIDBUFFERING, CHELATING, HUMECTANT

GLYCERETH-26 PHOSPHATECHELATING, SURFACTANT - EMULSIFYING

GRAPHENEBULKING; CHELATING; COLORANT; UV ABSORBER

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How GLUCONIC ACID appears in the CosIng inventory

The CosIng inventory lists GLUCONIC ACID as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

GLUCONIC ACID is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

GLUCONIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, GLUCONIC ACID carries the following function designation(s):

CAS 526-95-4 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for GLUCONIC ACID

This page reproduces the CosIng inventory entry for GLUCONIC ACID from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research GLUCONIC ACID and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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Tools & next steps

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