Is ESCULIN safe to use in EU cosmetics?

ESCULIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Always verify against the current official CosIng database before formulating.

What other records share CAS 531-75-9?

CAS 531-75-9 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

How do I check if my formula contains ESCULIN?

Use the INCI Checker to screen a full ingredient list across selected markets, or use the substance market comparison to review this identity across all supported market datasets.

InventoryRef 3379420/04/2018

ESCULIN

2H-1-Benzopyran-2-one, 6-(beta-D-glucopyranosyloxy)-7-hydroxy-

ESCULIN is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

INCI Checker Compare all markets Search similar

Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

Markets and their official sources Search every market for this name

Chemical identity and properties

PubChem 2D chemical structure for CAS 531-75-9

CAS 531-75-9PubChem CID 5281417

Esculin

Esculin is a hydroxycoumarin that is the 6-O-beta-D-glucoside of esculetin. It has a role as an antioxidant and a metabolite. It is a beta-D-glucoside and a hydroxycoumarin. It is functionally related to an esculetin. — ChEBI

IUPAC name: 7-hydroxy-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromen-2-one

Molecular formula: C15H16O9
Molecular weight: 340.28 g/mol
Exact mass: 340.07943208 Da
XLogP3: -0.6
Topological polar surface area: 146.0 Å²
Hydrogen-bond donors: 5
Hydrogen-bond acceptors: 9
Covalent units: 1
Defined stereocentres: 5

Also known as

Esculetin 6-O-glucoside6,7-Dihydroxycoumarin 6-glucosideEsculetin 6-beta-D-glucoside6,7-Dihydroxycoumarin-6-O-glucoside7-Hydroxy-6-cumarinyl-glucosid6-(beta-D-Glucopyranosyloxy)-7-hydroxy-cumarin1Y1L18LQAFCHEBI:4853

16 more reported names

NSC-266657-hydroxy-2-oxo-2H-chromen-6-yl beta-D-glucopyranoside2H-1-Benzopyran-2-one, 6-(beta-D-glucopyranosyloxy)-7-hydroxy-7-hydroxy-6-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl)oxychromen-2-oneRefChem:35731208-517-5686-183-3aesculinBicolorinEnallachromeCrataeginEscosylEsculineVitamin C2(-)-Esculin6-(beta-D-Glucopyranosyloxy)-7-hydroxy-2H-1-benzopyran-2-one

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:4853
ChEMBL:CHEMBL482581
EPA DTXSID:DTXSID7045318
PubMed:27038404
PubMed:22878250
PubMed:22858579
PubMed:22736101
PubMed:22675603
PubMed:22675588
PubMed:22643053
PubMed:22606036
PubMed:22529844
PubMed:22523469
PubMed:22428019
PubMed:22276121

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ESCULIN

INCI name

ESCULIN

Description

2H-1-Benzopyran-2-one, 6-(beta-D-glucopyranosyloxy)-7-hydroxy-

Record provenance

Inventory reference: 33794
Imported identity: ESCULIN
Source update: 20/04/2018

European Commission CosIng source notes

Annex records for ESCULIN

Browse

Browse EU annexes

Explore Annex II–VI to see which substances are prohibited, restricted or permitted under specific conditions.

Search annex entries

Search the annex database for entries matching ESCULIN or related substances.

Key data

CAS

531-75-9

208-517-5

Restriction

—

Function

LIGHT STABILIZER: Protecting the cosmetic product from deterioration effects of light.
TONIC: Producing a feeling of well-being on skin and hair.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#9989 · ESCULIN

Ingredients with overlapping formulation functions

DISODIUM SEBACATELIGHT STABILIZER

DISTARCH PHOSPHATE ACETATELIGHT STABILIZER, VISCOSITY CONTROLLING

DISTEARDIMONIUM HECTORITELIGHT STABILIZER, VISCOSITY CONTROLLING

DROMETRIZOLE TRISILOXANELIGHT STABILIZER, UV ABSORBER, UV FILTER

ETHYL DIMETHYL PABALIGHT STABILIZER

ETHYL ETHYLHEXYLAMINO DIMETHYLCYCLOHEXENYLIDENE CYANOACETATELIGHT STABILIZER

ETHYLHEXYL DIMETHYL PABALIGHT STABILIZER, UV ABSORBER, UV FILTER

ETHYLHEXYL METHOXYCINNAMATELIGHT STABILIZER, UV ABSORBER, UV FILTER

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How ESCULIN appears in the CosIng inventory

The CosIng inventory lists ESCULIN as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ESCULIN is also tagged with 2 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ESCULIN is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ESCULIN carries the following function designation(s):

CAS 531-75-9 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

View CAS records

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Open INCI Checker

Source note for ESCULIN

This page reproduces the CosIng inventory entry for ESCULIN from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ESCULIN and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

View sources View updates

Tools & next steps

Check your formula

Scan a full INCI list to detect ESCULIN and any linked EU annex restrictions or allergen flags.

INCI Checker

Search similar ingredients

Find other inventory ingredients and annex entries related to ESCULIN, its identifiers or nearby name variants.