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InventoryRef 3374206/08/2020

DROMETRIZOLE TRISILOXANE

Phenol,2-(2H-Benzotriazol-2-yl)-4-Methyl-6-(2-Methyl-3-(1,3,3,3-Tetramethyl-1-(Trimethylsilyl)Oxy)-Disiloxanyl)Propyl

DROMETRIZOLE TRISILOXANE is linked to 1 EU annex record on this page. Inventory note: VI/16.

Regulatory evidence by market

This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.

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MarketEvidence statusRecordsSource language
European UnionEvidence linked
Positive-list entry with conditions
Open this evidence
1English and EU languages
Great BritainEvidence linked
Permitted list with conditions
Open this evidence
1English
CanadaSource mapped
Official source mapped; ingredient rule not imported
0English and French
New ZealandEvidence linked
Permitted list with conditions
Open this evidence
1English
ASEANEvidence linked
Permitted list with conditions
Open this evidence
1English and national languages
ChinaSource mapped
Official source mapped; ingredient rule not imported
0Chinese with selected English material
JapanEvidence linked
Restricted
Open this evidence
1Japanese; official English translation available
South KoreaEvidence linked
Restricted
Open this evidence
1Korean with some English names
United StatesSource mapped
Official source mapped; ingredient rule not imported
0English
AustraliaSource mapped
Official source mapped; ingredient rule not imported
0English
BrazilSource mapped
Official source mapped; ingredient rule not imported
0Portuguese with INCI crosswalks
IndiaSource mapped
Official source mapped; ingredient rule not imported
0English and Hindi
Saudi ArabiaSource mapped
Official source mapped; ingredient rule not imported
0Arabic and English

Chemical identity and properties

PubChem 2D chemical structure for CAS 155633-54-8
CAS 155633-54-8PubChem CID 9848888

Drometrizole trisiloxane

Drometrizole trisiloxane is a photostable UVA and UVB light filter. The compound is a lipophilic benzotriazole derivative marketed as Meroxyl XL by L'Oreal, although sunscreens with drometrizole trisiloxane are currently only approved for use in the EU, Canada, Australia, and Japan, among other countries. Despite being used elsewhere in the world with relatively few reports of adverse reactions, the FDA continues to cite that the existing scientific record is not sufficient to establish the compound as being generally recognized as safe and effective for over-the-counter sunscreen use. DrugBank

IUPAC name
2-(benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[methyl-bis(trimethylsilyloxy)silyl]propyl]phenol
Molecular formula
C24H39N3O3Si3
Molecular weight
501.8 g/mol
Exact mass
501.22992172 Da
Topological polar surface area
69.4 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
5
Covalent units
1
Defined stereocentres
0

Also known as

SilatrizoleMexoryl XLOR 10154OR-101542-(2H-1,2,3-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-(2,2,4,6,6-pentamethyl-3,5-dioxa-2,4,6-trisilaheptan-4-yl)propyl]phenolPhenol, 2-(2H-benzotriazol-2-yl)-4-methyl-6-(2-methyl-3-(1,3,3,3-tetramethyl-1-((trimethylsilyl)oxy)-1-disiloxanyl)propyl)-Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-6-(2-methyl-3-(1,3,3,3-tetramethyl-1-((trimethylsilyl)oxy)disiloxanyl)propyl)-Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxanyl]propyl]-
16 more reported names
2-(2H-1,2,3-benzotriazol-2-yl)-4-methyl-6-(2-methyl-3-(2,2,4,6,6-pentamethyl-3,5-dioxa-2,4,6-trisilaheptan-4-yl)propyl)phenolRefChem:135828919-634-2Drometrizole trisiloxane [WHO-DD]2-(2H-Benzo[d][1,2,3]triazol-2-yl)-6-(3-(1,1,1,3,5,5,5-heptamethyltrisiloxan-3-yl)-2-methylpropyl)-4-methylphenolUNII-HC22845I1XDrometrizole trisiloxane [INCI]2-(2H-Benzo[d][1,2,3]triazol-2-yl)-6-[3-(1,1,1,3,5,5,5-heptamethyltrisiloxan-3-yl)-2-methylpropyl]-4-methylphenolEBC-27246HY-W419643DROMETRIZOLE TRISILOXANE [USP-RS]2-(2h-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl]phenolTS-10004DB-091411CS-0539357Drometrizole trisiloxane, analytical standard
External database identifiers

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for DROMETRIZOLE TRISILOXANE

INCI name

DROMETRIZOLE TRISILOXANE

Description

Phenol,2-(2H-Benzotriazol-2-yl)-4-Methyl-6-(2-Methyl-3-(1,3,3,3-Tetramethyl-1-(Trimethylsilyl)Oxy)-Disiloxanyl)Propyl

Record provenance

Inventory reference
33742
Imported identity
DROMETRIZOLE TRISILOXANE
Source update
06/08/2020
European Commission CosIng source notes

Key data

EC
Restriction
VI/16
Function
LIGHT STABILIZER
Protecting the cosmetic product from deterioration effects of light.
UV ABSORBER
Protecting the cosmetic product from the effects of UV-light.
UV FILTER
Exclusively or mainly intended to protect the skin and/or hair against certain UV radiation by absorbing, reflecting or scattering UV radiation. All authorised UV filters are substances in the positive list of Annex VI to the Cosmetics Regulation 1223/2009.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

The 6 markets that hold a rule for this substance do not classify it the same way.

restricted
JapanSouth Korea
permitted on a positive list
European UnionGreat BritainNew ZealandASEAN

See every substance the markets disagree about

Ingredients with overlapping formulation functions

Additional official and scientific sources

11 external databases to check this identity in

How DROMETRIZOLE TRISILOXANE appears in the CosIng inventory

The CosIng inventory lists DROMETRIZOLE TRISILOXANE as a cosmetic ingredient and this page links it to 1 annex record. The inventory entry captures names and identifiers, while the annex record shows where the substance is prohibited, restricted or positively listed in EU cosmetics law.

DROMETRIZOLE TRISILOXANE is also tagged with 3 cosmetic functions in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

DROMETRIZOLE TRISILOXANE appears in the EU CosIng inventory and has linked annex records. Check the annex records above for applicable restrictions, concentration limits and conditions of use. Annex II listing means prohibited; Annex III means restricted; Annexes IV, V and VI mean permitted under specified conditions.

The restriction field for DROMETRIZOLE TRISILOXANE reads: "VI/16". This is the restriction note recorded in the CosIng inventory for this ingredient. For authoritative conditions and limits, always refer to the linked annex entries above.

According to the EU CosIng inventory, DROMETRIZOLE TRISILOXANE carries the following function designation(s):

CAS 155633-54-8 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.

Source note for DROMETRIZOLE TRISILOXANE

This page combines the CosIng inventory entry for DROMETRIZOLE TRISILOXANE with 1 linked Annex II–VI record from the local dataset built from public European Commission cosmetic ingredient materials.

Use this inventory page to research DROMETRIZOLE TRISILOXANE and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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