InventoryRef 3214715/10/2010
BENZOPHENONE-8
2,2'-Dihydroxy-4-methoxybenzophenone
BENZOPHENONE-8 is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.
Regulatory evidence by market
This matrix separates verified ingredient rules from sources that are mapped but not yet imported. No imported rule does not mean the ingredient is permitted.
Swipe or scroll horizontally to see every column.
| Market | Evidence status | Records | Source language |
|---|---|---|---|
| European Union | Source mapped Inventory entry; no linked annex rule | 0 | English and EU languages |
| Great Britain | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Canada | Source mapped Official source mapped; ingredient rule not imported | 0 | English and French |
| New Zealand | Evidence linked Permitted list with conditions Open this evidence | 1 | English |
| ASEAN | Source mapped Official source mapped; ingredient rule not imported | 0 | English and national languages |
| China | Source mapped Official source mapped; ingredient rule not imported | 0 | Chinese with selected English material |
| Japan | Source mapped Official source mapped; ingredient rule not imported | 0 | Japanese; official English translation available |
| South Korea | Evidence linked Restricted Open this evidence | 1 | Korean with some English names |
| United States | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Australia | Source mapped Official source mapped; ingredient rule not imported | 0 | English |
| Brazil | Source mapped Official source mapped; ingredient rule not imported | 0 | Portuguese with INCI crosswalks |
| India | Source mapped Official source mapped; ingredient rule not imported | 0 | English and Hindi |
| Saudi Arabia | Source mapped Official source mapped; ingredient rule not imported | 0 | Arabic and English |
Chemical identity and properties
CAS 131-53-3PubChem CID 8569
2,2'-Dihydroxy-4-methoxybenzophenone
2,2'-Dihydroxy-4-methoxybenzophenone is a member of benzophenones. — ChEBI
- IUPAC name
- (2-hydroxy-4-methoxyphenyl)-(2-hydroxyphenyl)methanone
- Molecular formula
- C14H12O4
- Molecular weight
- 244.24 g/mol
- Exact mass
- 244.07355886 Da
- XLogP3
- 3.3
- Topological polar surface area
- 66.8 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 4
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
dioxybenzoneDioxybenzonSpectra-sorb UV 24Cyasorb UV 24(2-Hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)methanoneAdvastab 47Methanone, (2-hydroxy-4-methoxyphenyl)(2-hydroxyphenyl)-Dioxibenzona
16 more reported names
DioxibenzonumCyasorb UV 24 Light AbsorberUV 24DioxybenzonumNSC-56769Benzophenone, 2,2'-dihydroxy-4-methoxy-B762XZ551X(2-hydroxy-4-methoxy-phenyl)-(2-hydroxyphenyl)methanoneRefChem:440272205-026-8Benzophenone-8UF 22-(2-hydroxybenzoyl)-5-methoxyphenolBenzophenone-8;UV-242,2-Dihydroxy-4-Methoxybenzophenone2,2'-dihydroxy-4-methoxy benzophenone
External database identifiers
- ChEBI:CHEBI:34208
- ChEMBL:CHEMBL1326877
- EPA DTXSID:DTXSID3022403
- PubMed:37217011
- PubMed:32407875
- PubMed:28959646
- PubMed:28927721
- PubMed:27690075
- PubMed:25349334
- PubMed:23749905
- PubMed:23013281
- PubMed:22346740
- PubMed:21250822
- PubMed:20557889
- PubMed:19298877
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match8569
Attributed physical-property, hazard, environmental and use annotations.
- Boiling Point: 338 to 347 °F at 1 mmHg (NTP, 1992) Source: CAMEO Chemicals
- Boiling Point: 172.5 Source: DrugBank
- Boiling Point: BP: 172 °C at 1 mm Hg Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Yellow powder Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.39 g/cu cm at 22.7 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: 74 Source: DrugBank
- Melting Point: 68 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: MP: 70.6-77.2 °C Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: 2,2'-dihydroxy-4-methoxybenzophenone is a yellow powder. (NTP, 1992) Source: CAMEO Chemicals
- Physical Description: Dry Powder Source: EPA Chemical Data Reporting (CDR)
- Solubility: Practically insoluble in water Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Solubility in g/100 mL at 25 °C: ethanol 21.8; isopropanol 17; propylene glycol6.2; ethylene glycol 3.0; n-hexane 1.5 Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Freely soluble in alcohol, toluene Source: Hazardous Substances Data Bank (HSDB)
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
- Note: This chemical does not meet GHS hazard criteria for 9.8% (5 of 51) of reports. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H315 (84.3%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (84.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335 (80.4%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 51 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 5 of 51 reports by companies.; There are 7 notifications provided by 46 of 51 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Warning Source: Hazardous Substances Data Bank (HSDB)
- GHS Hazard Statements: H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: Hazardous Substances Data Bank (HSDB)
- Precautionary Statement Codes: P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement) Source: Hazardous Substances Data Bank (HSDB)
- Cosmetic Ingredient Review Finding(s): Safe in the present practices of use and concentration. Ingredient, concentration, and use information are available in documents discoverable at https://cir-reports.cir-safety.org Source: Cosmetic Ingredient Review (CIR)
- Toxicity Summary: IDENTIFICATION AND USE: 2,2'-Dihydroxy-4-methoxybenzophenone (dioxybenzone) is a solid, which is used as a benzophenone sunscreen agent. Many sunscreens contain UVA-absorbing avobenzone or a benzophenone (such as dioxybenzone, oxybenzone, or sulisobenzone), in addition to UVB-absorbing chemical ingredients (some of which also contribute to UVA protection). HUMAN STUDIES: There are no human toxicity studies available. Although it has been suggested that benzophenone derivatives may protect against photosensitivity reactions to photosensitizing drugs (e.g., chlordiazepoxide, chlorpromazine, demeclocycline, hydrochlorothiazide, nalidixic acid, nystatin, sulfisoxazole), most clinicians agree that these sunscreens provide, at most, only limited protection for patients who are sensitive to these drugs. ANIMAL STUDIES: Dioxybenzone was nonmutagenic when assayed directly and was weakly mutagenic with metabolic activation in Salmonella strain TA1537. Dioxybenzone was not mutagenic in vivo in the mouse micronucleus test. In mice, signs of toxicity including decreased activity, piloerection, and exophthalmus were observed at doses of 166-5000 mg/kg. Dioxybenzone given orally delayed skin tumo Source: Hazardous Substances Data Bank (HSDB)
- Environmental Bioconcentration: An estimated BCF of 40 was calculated in fish for 2,2'-dihydroxy-4-methoxybenzophenone(SRC), using an estimated log Kow of 3.82(1) and a regression-derived equation(1). According to a classification scheme(2), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1300(SRC), determined from a structure estimation method(2), indicates that 2,2'-dihydroxy-4-methoxybenzophenone is expected to have low mobility in soil(SRC). Volatilization of 2,2'-dihydroxy-4-methoxybenzophenone from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.0X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). 2,2'-Dihydroxy-4-methoxybenzophenone is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 2.0X10-7 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). Utilizing the CO2 Evolution Test, 0% CO2 Evolution was reached in 28 days(3) indicating that biodegradation is not an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1300(SRC), determined from a structure estimation method(2), indicates that 2,2'-dihydroxy-4-methoxybenzophenone is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.0X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). According to a classification scheme(4), an estimated BCF of 40(SRC), from an estimated log Kow of 3.82(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Utilizing the CO2 Evolution Test, 0% CO2 Evolution was reached in 28 days(5) indicating that biodegradation is not an important environmental fate process in water(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2,2'-dihydroxy-4-methoxybenzophenone, which has an estimated vapor pressure of 2.0X10-7 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), will exist in both the vapor and particulate phases in the ambient atmosphere. Vapor-phase 2,2'-dihydroxy-4-methoxybenzophenone is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 2 hours(SRC), calculated from its rate constant of 2.0X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(2). Particulate-phase 2,2'-dihydroxy-4-methoxybenzophenone may be removed from the air by wet and dry deposition(SRC). UV light absorbing substances, such as 2,2'-dihydroxy-4-methoxybenzophenone, accepted as a means of protecting skin against UV radiation damage, absorb UV light in the range of 285-400 nm(2) suggesting that this compound may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Industry Uses: UV stabilizer Source: EPA Chemical Data Reporting (CDR)
- Cosmetic Ingredient Review Link: CIR ingredient: Benzophenone-8 Source: Cosmetic Ingredient Review (CIR)
- Uses: Broad-spectrum sunscreens often contain a number of chemical ingredients that absorb UVA and UVB radiation. Many sunscreens contain UVA-absorbing avobenzone or a benzophenone (such as dioxybenzone, oxybenzone, or sulisobenzone), in addition to UVB-absorbing chemical ingredients (some of which also contribute to UVA protection). Source: Hazardous Substances Data Bank (HSDB)
- Uses: Cosmetic Ultraviolet Absorber: benzophenone-8. /From table/ Source: Hazardous Substances Data Bank (HSDB)
- Uses: MEDICATION Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Inventory details for BENZOPHENONE-8
INCI name
BENZOPHENONE-8
INN name
dioxybenzone
Description
2,2'-Dihydroxy-4-methoxybenzophenone
Record provenance
- Inventory reference
- 32147
- Imported identity
- BENZOPHENONE-8
- Source update
- 15/10/2010
Annex records for BENZOPHENONE-8
Key data
Official EU ingredient-name evidence
The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.
The 2 markets that hold a rule for this substance do not classify it the same way.
- restricted
- South Korea
- permitted on a positive list
- New Zealand
Related inventory evidence
Ingredients with overlapping formulation functions
Additional official and scientific sources
11 external databases to check this identity in
Each link searches that source for this identity. What each source is, and its legal weight
ECHA CHEM / Information on chemicalsPubChem PUG RESTEU Safety Gate cosmetic product alertsECHA CHEMUS EPA CompToxCosmetic Ingredient Review safety assessmentsFDA Global Substance Registration SystemILO/WHO International Chemical Safety CardsJapan NITE-CHRIPNIOSH Pocket Guide to Chemical HazardsOECD eChemPortal
How BENZOPHENONE-8 appears in the CosIng inventory
The CosIng inventory lists BENZOPHENONE-8 as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.
BENZOPHENONE-8 is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.
Frequently asked questions
BENZOPHENONE-8 is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.
According to the EU CosIng inventory, BENZOPHENONE-8 carries the following function designation(s):
CAS 131-53-3 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.
Use the INCI Checker to screen a full ingredient list across selected markets, or compare this substance across all supported market datasets.
Source note for BENZOPHENONE-8
This page reproduces the CosIng inventory entry for BENZOPHENONE-8 from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.
Use this inventory page to research BENZOPHENONE-8 and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.
Tools & next steps
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