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CAS 1188-37-0 may appear across multiple EU annex records. The CAS lookup page shows all Annex II–VI entries sharing this identifier, useful for identifying cross-annex regulatory status of the same chemical substance.

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InventoryRef 3157715/10/2010

ACETYL GLUTAMIC ACID

N-acetylglutamic acid

ACETYL GLUTAMIC ACID is listed in the EU CosIng inventory, but no direct annex records are linked on this page yet.

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Regulatory evidence by market

No rule for this ingredient has been imported for any of the 13 markets tracked here.

That describes this inventory, not the law. No imported rule is not evidence that an ingredient is permitted: a rule may exist under another name or identifier, or in a dataset not yet imported here.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 1188-37-0

CAS 1188-37-0PubChem CID 70914

N-acetyl-L-glutamic acid

N-acetyl-L-glutamic acid is an N-acyl-L-amino acid that is L-glutamic acid in which one of the amine hydrogens is substituted by an acetyl group. It has a role as a Saccharomyces cerevisiae metabolite and a human metabolite. It is a N-acetyl-L-amino acid and a N-acyl-L-glutamic acid. It is functionally related to a L-glutamic acid. It is a conjugate acid of a N-acetyl-L-glutamate(1-). — ChEBI

IUPAC name: (2S)-2-acetamidopentanedioic acid

Molecular formula: C7H11NO5
Molecular weight: 189.17 g/mol
Exact mass: 189.06372245 Da
XLogP3: -1.8
Topological polar surface area: 104.0 Å²
Hydrogen-bond donors: 3
Hydrogen-bond acceptors: 5
Covalent units: 1
Defined stereocentres: 1

Also known as

acetylglutamic acidAcetyl-L-glutamic acidN-acetyl-L-glutamateAcetyl glutamic acidAc-Glu-OHL-N-Acetylglutamic acidL-Glutamic acid, N-acetyl-Glutamic acid, N-acetyl-, L-

16 more reported names

N-Ac-Glu-OHMA61H539YZCHEBI:17533N-acetyl-L-glutaminic acidFEMA NO. 4752N-ACETYL-S-GLUTAMIC ACID(2S)-2-(acetylamino)pentanedioic acidRefChem:1113280214-708-4N-AcetylglutamateGlutamic acid, N-acetyl-(S)-2-(acetylamino)pentanedioic acidNLG(S)-2-acetamidopentanedioic acidN-Acetyl-L-glutamicAcidAc-Glu

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:17533
ChEMBL:CHEMBL1234751
EPA DTXSID:DTXSID3046534
PubMed:29968805
PubMed:22848442
PubMed:22563224
PubMed:22558239
PubMed:22529931
PubMed:22496890
PubMed:22452987
PubMed:22448977
PubMed:22427966
PubMed:22402285
PubMed:22383952
PubMed:22370950

Evidence from additional scientific databases

NIH PubChem PUG-View

Exact identifier match70914

Attributed physical-property, hazard, environmental and use annotations.

Melting Point: 199 °C Source: DrugBank
Melting Point: 199 - 201 °C Source: Human Metabolome Database (HMDB)

Physical Description: Solid Source: Human Metabolome Database (HMDB)
Physical Description: White powder or white crystals; Savoury, cooked roasted Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Solubility: 52 mg/mL Source: Human Metabolome Database (HMDB)
Solubility: Soluble Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Solubility: Sparingly soluble (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)

Note: This chemical does not meet GHS hazard criteria for 93.8% (15 of 16) of all reports. Source: European Chemicals Agency (ECHA)
GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 15 of 16 companies (only 6.2% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
ECHA C&L Notifications Summary: Aggregated GHS information provided per 16 reports by companies from 2 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 15 of 16 reports by companies.; There is 1 notification provided by 1 of 16 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)

Cosmetic Ingredient Review Conclusion: The panel concluded that the 115 amino acid alkyl amides listed below are safe in the present practices of use and concentration in cosmetics, when formulated to be non-irritating...Acetyl Glutamic Acid Source: Cosmetic Ingredient Review (CIR)
Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)

Cosmetic Ingredient Review Link: CIR ingredient: Acetyl Glutamic Acid Source: Cosmetic Ingredient Review (CIR)

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status

Source	Result	Checked
NIH PubChem PUG-View	Exact match	2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Inventory details for ACETYL GLUTAMIC ACID

INCI name

ACETYL GLUTAMIC ACID

Description

N-acetylglutamic acid

Record provenance

Inventory reference: 31577
Imported identity: ACETYL GLUTAMIC ACID
Source update: 15/10/2010

European Commission CosIng source notes

Annex records for ACETYL GLUTAMIC ACID

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Key data

CAS

1188-37-0

214-708-4

Restriction

—

Function

SKIN CONDITIONING: Maintaining the skin in good condition.

Official EU ingredient-name evidence

The ingredient name exactly matches the official 2025 EU glossary of common ingredient names.

#627 · ACETYL GLUTAMIC ACID

Ingredients with overlapping formulation functions

ACETYL FARNESYLCYSTEINEREDUCING, SKIN CONDITIONING

ACETYL GALACTOSAMINEHUMECTANT, SKIN CONDITIONING

ACETYL GLUCOSAMINESKIN CONDITIONING

ACETYL GLUCOSAMINE ETHYL ETHERHUMECTANT, SKIN CONDITIONING

ACETYL GLUTAMINESKIN CONDITIONING

ACETYL GLYCERYL RICINOLEATESKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

ACETYL GLYCYL BETA-ALANINESKIN CONDITIONING

ACETYL HEPTAPEPTIDE-19 AMIDESKIN CONDITIONING

Additional official and scientific sources

11 external databases to check this identity in

Each link searches that source for this identity. What each source is, and its legal weight

ECHA CHEM / Information on chemicals PubChem PUG REST EU Safety Gate cosmetic product alerts ECHA CHEM US EPA CompTox Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal

How ACETYL GLUTAMIC ACID appears in the CosIng inventory

The CosIng inventory lists ACETYL GLUTAMIC ACID as a cosmetic ingredient and this page links it to 0 annex records. The inventory entry captures names and identifiers, while the annex records show where the substance is prohibited, restricted or positively listed in EU cosmetics law.

ACETYL GLUTAMIC ACID is also tagged with 1 cosmetic function in the official data. Function labels describe intended use, but they do not replace regulatory review of linked annex records before formulation or labelling work.

Frequently asked questions

ACETYL GLUTAMIC ACID is listed in the EU CosIng ingredient inventory with no direct annex restriction records linked at this time. Absence of an annex link does not guarantee unrestricted use — always verify against the current official CosIng database before formulating.

According to the EU CosIng inventory, ACETYL GLUTAMIC ACID carries the following function designation(s):

SKIN CONDITIONING

CAS 1188-37-0 may appear across multiple EU annex records. Viewing the CAS lookup page shows all Annex II–VI entries sharing this identifier, which is useful for identifying cross-annex regulatory status of the same chemical substance.

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Source note for ACETYL GLUTAMIC ACID

This page reproduces the CosIng inventory entry for ACETYL GLUTAMIC ACID from public European Commission cosmetic ingredient materials and shows linked identifiers even when no direct annex match is currently attached.

Use this inventory page to research ACETYL GLUTAMIC ACID and compare linked records, but verify restrictions and legal status against the current official source text and law before making regulatory decisions.

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