N-acetyl-L-glutamic acid
N-acetyl-L-glutamic acid is an N-acyl-L-amino acid that is L-glutamic acid in which one of the amine hydrogens is substituted by an acetyl group. It has a role as a Saccharomyces cerevisiae metabolite and a human metabolite. It is a N-acetyl-L-amino acid and a N-acyl-L-glutamic acid. It is functionally related to a L-glutamic acid. It is a conjugate acid of a N-acetyl-L-glutamate(1-). — ChEBI
- IUPAC name
- (2S)-2-acetamidopentanedioic acid
- Molecular formula
- C7H11NO5
- Molecular weight
- 189.17 g/mol
- Exact mass
- 189.06372245 Da
- XLogP3
- -1.8
- Topological polar surface area
- 104.0 Ų
- Hydrogen-bond donors
- 3
- Hydrogen-bond acceptors
- 5
- Covalent units
- 1
- Defined stereocentres
- 1
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:17533
- ChEMBL:CHEMBL1234751
- EPA DTXSID:DTXSID3046534
- PubMed:29968805
- PubMed:22848442
- PubMed:22563224
- PubMed:22558239
- PubMed:22529931
- PubMed:22496890
- PubMed:22452987
- PubMed:22448977
- PubMed:22427966
- PubMed:22402285
- PubMed:22383952
- PubMed:22370950
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Melting Point: 199 °C Source: DrugBank
- Melting Point: 199 - 201 °C Source: Human Metabolome Database (HMDB)
- Physical Description: Solid Source: Human Metabolome Database (HMDB)
- Physical Description: White powder or white crystals; Savoury, cooked roasted Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: 52 mg/mL Source: Human Metabolome Database (HMDB)
- Solubility: Soluble Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: Sparingly soluble (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Note: This chemical does not meet GHS hazard criteria for 93.8% (15 of 16) of all reports. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 15 of 16 companies (only 6.2% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 16 reports by companies from 2 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 15 of 16 reports by companies.; There is 1 notification provided by 1 of 16 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Cosmetic Ingredient Review Conclusion: The panel concluded that the 115 amino acid alkyl amides listed below are safe in the present practices of use and concentration in cosmetics, when formulated to be non-irritating...Acetyl Glutamic Acid Source: Cosmetic Ingredient Review (CIR)
- Cosmetic Ingredient Review Finding(s): Safe for use in cosmetics, with qualifications Source: Cosmetic Ingredient Review (CIR)
- Cosmetic Ingredient Review Link: CIR ingredient: Acetyl Glutamic Acid Source: Cosmetic Ingredient Review (CIR)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.