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Official EU label nameGlossary entry 8984

DIMETHYL MEA

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

0 markets with evidence
Markets checked
13
Markets with evidence
0
Evidence gaps
13
Resolved identifiers
2

A missing local match is not permission, approval or proof of safety. It means no strong identity match was resolved in that indexed dataset.

Resolved substance identity

CAS:108-01-0
EC:203-542-8
Ingredient index records:
DIMETHYL MEA
Cosmetic functions: BUFFERING

2-Dimethylaminoethanol; N,N-Dimethyl-2-aminoethanol

Inventory restriction note: III/62

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1 matched or reported name
DIMETHYL MEA

Regulatory evidence in all 13 markets

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MarketResultRecordsDatasetMeaning / next action
European Union
EU
No local match0
Complete annex dataset
Regulation (EC) 1223/2009 consolidated to 1 May 2026
No annex match only means that these five annexes did not return a match; CosIng identity data and other EU obligations still need review.
Great Britain
GB
No local match0
Complete consolidated annex dataset
GB retained Regulation 1223/2009 schedules, effective 15 August 2026
No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework.
Canada
CA
No local match0
Complete Hotlist snapshot
Health Canada Cosmetic Ingredient Hotlist, 13 August 2025
The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.
New Zealand
NZ
No local match0
Complete schedules dataset
Cosmetic Products Group Standard schedules effective 1 January 2026
The searchable spreadsheet is an aid; the legal Group Standard and incorporated notices remain authoritative.
ASEAN
ASEAN
No local match0
Complete regional annex dataset
ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026
Regional annex coverage does not replace member-state implementation dates, notifications or national deviations.
China
CN
No local match0
Complete prohibited catalogues plus official-source workflow
NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025
IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.
Japan
JP
No local match0
Complete Standards appendices dataset
MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot
The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.
South Korea
KR
No local match0
Complete current appendix dataset
MFDS Notice 2026-19, effective 18 March 2026
Korean source wording is canonical and other positive lists/notices may still apply to the formulation.
United States
US
No local match0
Complete enumerated federal ingredient rules
eCFR Title 21 issue date 27 August 2026
FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety.
Australia
AU
No local match0
Complete cosmetic-relevant Poisons Standard subset plus official workflow
Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026
An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.
Brazil
BR
No local match0
Complete prohibited dataset plus current restricted-list workflow
ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026
RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.
India
IN
No local match0
Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4
Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)
The standards are separate controlled publications; absence from a locally indexed excerpt is not permission.
Saudi Arabia
SA
No local match0
Complete official list index
SFDA live prohibited/restricted lists, snapshot 30 August 2026
No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply.
No market rows match this filter.

Chemical identity and properties

PubChem 2D chemical structure for CAS 108-01-0
CAS 108-01-0PubChem CID 7902

2-(Dimethylamino)ethanol

IUPAC name
2-(dimethylamino)ethanol
Molecular formula
C4H11NO
Molecular weight
89.14 g/mol
Exact mass
89.084063974 Da
XLogP3
-0.4
Topological polar surface area
23.5 Ų
Hydrogen-bond donors
1
Hydrogen-bond acceptors
2
Covalent units
1
Defined stereocentres
0

Also known as

DeanolN,N-DimethylethanolamineDimethylaminoethanol2-DIMETHYLAMINOETHANOLNorcholineBimanolLiparonVaresal
16 more reported names
N,N-DimethylaminoethanolPropamine A(2-Hydroxyethyl)dimethylamineKalpur PDimethylmonoethanolamineEthanol, 2-(dimethylamino)-DimethylaminoaethanolN,N-Dimethyl-2-hydroxyethylamine2-(N,N-Dimethylamino)ethanolAmietol M 21N,N-Dimethyl-2-aminoethanolN-DimethylaminoethanolTexacat DMEDimethyl(2-hydroxyethyl)amineDimethyl(hydroxyethyl)amineDimethylaethanolamin
Open full PubChem recordPubChem annotations3D structure image
External database identifiers

Evidence from additional scientific databases

NIH PubChem PUG-View
Exact identifier match7902

Attributed physical-property, hazard, environmental and use annotations.

  • First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whene Source: CAMEO Chemicals
  • ERG2024, Guide 132 (2-Dimethylaminoethanol): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
  • Signal: Danger Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H312: Harmful in contact with skin [Warning Acute toxicity, dermal]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P260, P261, P264, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
  • Note: This chemical does not meet GHS hazard criteria for 0.2% (2 of 1289) of reports. Source: European Chemicals Agency (ECHA)
  • Signal: Danger Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H226 (99.8%): Flammable liquid and vapor [Warning Flammable liquids]; H302+H312 (23.9%): Harmful if swallowed or in contact with skin [Warning Acute toxicity, oral; acute toxicity, dermal]; H302 (99.8%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (99.8%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H314 (99.8%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H318 (37.6%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H331 (34.2%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H332 (65.6%): Harmful if inhaled [Warning Acute toxicity, inhalation]; H335 (38.6%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] Source: European Chemicals Agency (ECHA)
  • Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P317, P319, P321, P330, P362+P364, P363, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
  • ECHA C&L Notifications Summary: Aggregated GHS information provided per 1289 reports by companies from 46 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Reported as not meeting GHS hazard criteria per 2 of 1289 reports by companies.; There are 45 notifications provided by 1287 of 1289 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
  • GHS Hazard Statements: H402: Harmful to aquatic life [Hazardous to the aquatic environment, acute hazard] Source: NITE-CMC
  • Precautionary Statement Codes: P273, and P501 (click each P-code to see the statement) Source: NITE-CMC
  • Signal: Danger Source: NITE-CMC
  • GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H318: Causes serious eye damage [Danger Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H373: May causes damage to organs through prolonged or repeated exposure [Warning Specific target organ toxicity, repeated exposure] Source: NITE-CMC
  • NFPA Health Rating: 3 - Materials that, under emergency conditions, can cause serious or permanent injury. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
  • NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
  • Toxicity Summary: IDENTIFICATION AND USE: 2-Dimethylaminoethanol (DMAE) is a colorless liquid. DMAE has been used as an ingredient in skin care, and in cognitive function- and mood-enhancing products. Deaner(DMAE p-acetamidobenzoate) was a U.S. prescription drug for more than 20 years until 1983 when it was withdrawn from the market. It was used to treat children with learning and behavior problems. A large number of dietary supplements contain DMAE. The predominant form, when specified, is DMAE bitartrate. DMAE has applications in the chemical and pharmaceutical industries. HUMAN EXPOSURE AND TOXICITY: Severe respiratory symptoms were observed in a single painter exposed to spray paint containing DMAE. Wheal and flare responses occurred after exposure of human volunteers to DMAE but it was interpreted as an irritant. DMAE tartrate administered orally to humans produced mild mental stimulation. At 20 mg/day, there was a gradual increase in muscle tone and perhaps an increased frequency of convulsions in susceptible individuals. Larger doses produced insomnia, muscle tenseness, and spontaneous muscle twitches. Serious cholinergic side effects were reported in a 37-yr-old woman with tardive dyskinesia Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for 2-dimethylaminoethanol(SRC), using a log Kow of -0.55(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that 2-dimethylaminoethanol is expected to have very high mobility in soil(SRC). The pKa of 2-dimethylaminoethanol is 9.3(3). At pH 8.2, 20% will be the free amine. Thus, this compound will exist almost entirely in the cation form in the environment and cations generally adsorb to organic carbon and clay more strongly than their neutral counterparts(4). As a result, 2-dimethylaminoethanol may have greater adsorption and less mobility than its estimated Koc value indicates. Volatilization of 2-dimethylaminoethanol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.8X10-9 atm-cu m/mole(SRC), using a fragment constant estimation method(2). 2-Dimethylaminoethanol may volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 3.18 mm Hg at 25 °C(5). A 60.5% of theoretical BOD in two weeks using activated sludge in the Japanese MITI test indicates that 2-dimethylaminoethanol is readily biodegradable(6) and suggests that biodegradation is an important environme Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that 2-dimethylaminoethanol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 1.8X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). According to a classification scheme(4), an estimated BCF of 3(SRC), from its log Kow of -0.55(5) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). A 60.5% of theoretical BOD in two weeks using activated sludge in the Japanese MITI test indicates that 2-dimethylaminoethanol is readily biodegradable(6) and suggests that biodegradation is an important environmental fate process in soil(SRC). Results of another screening test found that 2-dimethylaminoethanol biodegrades readily(7). 2-Dimethylaminoethanol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). Source: Hazardous Substances Data Bank (HSDB)
  • Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 2-dimethylaminoethanol, which has a vapor pressure of 3.18 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 2-dimethylaminoethanol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 4.3 hours(SRC), calculated from its rate constant of 9.0X10-11 cu cm/molecule-sec at 25 °C(3). Vapor-phase 2-dimethylaminoethanol is also degraded in the atmosphere by reaction with ozone(SRC); the half-life for this reaction in air is estimated to be 1.7 days(SRC), calculated from its rate constant of 6.71X10-18 cu cm/molecule-sec at 25 °C(3). Source: Hazardous Substances Data Bank (HSDB)
  • Consumer Uses: Processing aids, specific to petroleum production; Emulsifier; Catalyst; Corrosion inhibitor; Not Known or Reasonably Ascertainable; Monomers; pH regulating agent; Solvent Source: EPA Chemical Data Reporting (CDR)
  • Industry Uses: Processing aids, specific to petroleum production; Intermediate; Not Known or Reasonably Ascertainable; Corrosion inhibitor; Catalyst; Emulsifier; pH regulating agent; Monomers; Polymerization promoter Source: EPA Chemical Data Reporting (CDR)
  • Sources/Uses: Used as a curing agent for polyurethanes and epoxy resins; used as a chemical intermediate for pharmaceuticals, dyes, corrosion inhibitors, and emulsifiers; also used as an additive to boiler water, paint removers, and amino resins; [HSDB] Has been used therapeutically as a CNS stimulant; [Merck Index # 2843] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Industrial Processes with risk of exposure: Painting (Pigments, Binders, and Biocides) [Category: Paint]; Plastic Composites Manufacturing [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
  • Uses: CHEM INT FOR ANTIHISTAMINES AND LOCAL ANESTHETICS; CATALYST FOR CURING EPOXY RESINS AND POLYURETHANES; PH CONTROL AGENT FOR BOILER WATER TREATMENT Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Solvent and ligand in organic synthesis; accelerator in epoxy resin formulations. As corrosion inhibitor in steel-reinforced concrete. Salts as dietary supplement, tonic. In cosmetics as antiwrinkle and skin firming agent. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Intermediate in the synthesis of dyestuffs, textile auxiliaries, pharmaceuticals, and corrosion inhibitors; curing epoxy, amine, and polyamide resins; emulsifier in paints and coatings. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Used to scavenge hydrochloric acid which is released when methylene chloride decomposes after use as a paint or varnish remover Source: Hazardous Substances Data Bank (HSDB)
  • Uses: For more Uses (Complete) data for 2-DIMETHYLAMINOETHANOL (9 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
  • Uses: Use (kg; approx.) in Germany (2009): >750; Consumption (g per capita; approx.) in Germany (2009): 0.00916; Excretion rate: 1; Calculated removal (%): 92.1 Source: NORMAN Suspect List Exchange

Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record

Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.

Additional source coverage and match status
SourceResultChecked
NIH PubChem PUG-ViewExact match2026-08-31

A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

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Cosmetic Ingredient Review safety assessments

Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents

Independent expert review considered by FDA; not a government approval or binding market rule

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FDA Global Substance Registration System

UNII identifiers, preferred names, substance types, codes and public substance relationships

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ILO/WHO International Chemical Safety Cards

Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals

International occupational chemical-safety reference; not cosmetic-use approval

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Japan NITE-CHRIP

Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information

Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules

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NIOSH Pocket Guide to Chemical Hazards

REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals

US occupational-health guidance and limits; not a cosmetic ingredient decision

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OECD eChemPortal

Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records

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US EPA CompTox CTX APIs

DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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