Official EU label nameGlossary entry 8587
DIETHYLENE GLYCOL
This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.
Global evidence snapshot
The resolved identity has matching regulatory evidence in 11 of 13 indexed market datasets: 14 country records and 1 EU Annex records. Every result and evidence gap is listed below.
Markets checked
13
Markets with evidence
11
Evidence gaps
2
Resolved identifiers
2
Resolved substance identity
CAS:111-46-6
EC:203-872-2
Ingredient index records:
DIETHYLENE GLYCOL
Cosmetic functions: FRAGRANCE, PERFUMING, SOLVENT, VISCOSITY CONTROLLING
2,2'-Oxydiethanol; DEG
Inventory restriction note: II/1370 III/186
14 matched or reported names
DIETHYLENE GLYCOL2,2'-oxydiethanol
Diethylene glycol (DEG)Diethylene glycol (DEG); 2,2′-oxydiethanol for traces level, see Annex IIIDiethylene glycolDiethylene glycol (DEG) or 2,2'-oxydiethanol, for traces level see Schedule 5, entry 186Diethylene glycol (DEG; 2,2′-oxydiethanol)Diethylene glycol (except if it is present as unavoidable trace limit二甘醇 — Diethylene glycol （DEG） （CAS No. 111-46-6）디에칠렌글라이콜 (다만, 비의도적 잔류물로서 0.1% 이하인 경우는 제외)Dietileno glicol, para traços ver em outras listas de substâncias-oxydiethanol for traces level, Annex B (CAS No. 111-46-6) Diethylene glycol (DEG); 2,2′ seeDiethylene glycol (DEG) (CAS No. 111-46-6) - 2,2’ oxydiethanolDiethylene glycol (DEG); 2,2'-oxydiethanol for traces level, see Annex III2,2'-oxydiethanol Diethylene glycol (DEG)
Regulatory evidence in all 13 markets
Open each matched record for its scope, concentration, conditions, warnings and official source version.
Swipe or scroll horizontally to see dataset coverage and next actions.
| Market | Result | Records | Dataset | Meaning / next action |
|---|---|---|---|---|
| European Union EU | Restricted | 1Open record 1 | Complete annex dataset Regulation (EC) 1223/2009 consolidated to 1 May 2026 | Review every linked record and exact conditions. |
| Great Britain GB | Prohibited | 2Open record 1Open record 2 | Complete consolidated annex dataset GB retained Regulation 1223/2009 schedules, effective 15 August 2026 | Review every linked record and exact conditions. |
| Canada CA | Restricted | 1Open record 1 | Complete Hotlist snapshot Health Canada Cosmetic Ingredient Hotlist, 13 August 2025 | Review every linked record and exact conditions. |
| New Zealand NZ | Prohibited | 2Open record 1Open record 2 | Complete schedules dataset Cosmetic Products Group Standard schedules effective 1 January 2026 | Review every linked record and exact conditions. |
| ASEAN ASEAN | Prohibited | 1Open record 1 | Complete regional annex dataset ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026 | Review every linked record and exact conditions. |
| China CN | Prohibited | 1Open record 1 | Complete prohibited catalogues plus official-source workflow NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025 | Review every linked record and exact conditions. |
| Japan JP | No local match | 0 | Complete Standards appendices dataset MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot | The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion. |
| South Korea KR | Prohibited | 1Open record 1 | Complete current appendix dataset MFDS Notice 2026-19, effective 18 March 2026 | Review every linked record and exact conditions. |
| United States US | No local match | 0 | Complete enumerated federal ingredient rules eCFR Title 21 issue date 27 August 2026 | FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety. |
| Australia AU | Prohibited | 1Open record 1 | Complete cosmetic-relevant Poisons Standard subset plus official workflow Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026 | Review every linked record and exact conditions. |
| Brazil BR | Prohibited | 1Open record 1 | Complete prohibited dataset plus current restricted-list workflow ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026 | Review every linked record and exact conditions. |
| India IN | Prohibited | 2Open record 1Open record 2 | Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4 Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022) | Review every linked record and exact conditions. |
| Saudi Arabia SA | Prohibited | 2Open record 1Open record 2 | Complete official list index SFDA live prohibited/restricted lists, snapshot 30 August 2026 | Review every linked record and exact conditions. |
No market rows match this filter.
Matching market records and conditions
Great Britain
GB retained Regulation 1223/2009 schedules, effective 15 August 2026Canada
Health Canada Cosmetic Ingredient Hotlist, 13 August 2025New Zealand
Cosmetic Products Group Standard schedules effective 1 January 2026Diethylene glycol (DEG) or 2,2'-oxydiethanol, for traces level see Schedule 5, entry 186Prohibited
Schedule 4, reference 1370, source row 1449 · effective-2026-01-01
Diethylene glycol (DEG; 2,2′-oxydiethanol)Restricted
Product scope: As traces in ingredients · Maximum concentration: 0.1%
Schedule 5, reference 186, source row 220 · effective-2026-01-01
ASEAN
ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026China
NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025South Korea
MFDS Notice 2026-19, effective 18 March 2026Australia
Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026Brazil
ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026India
Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)-oxydiethanol for traces level, Annex B (CAS No. 111-46-6) Diethylene glycol (DEG); 2,2′ seeProhibited
Must not form part of the composition of cosmetic products. Apply the general trace and safety notes published after Annex A.
IS 4707 (Part 2):2025 Annex A, entry 1343 · IS 4707 (Part 2):2025, fifth revision
Diethylene glycol (DEG) (CAS No. 111-46-6) - 2,2’ oxydiethanolRestricted
Field of application/use: As traces in ingredients 0.1 percent
IS 4707 (Part 2):2025 Annex B, entry 181 · IS 4707 (Part 2):2025, fifth revision
Saudi Arabia
SFDA live prohibited/restricted lists, snapshot 30 August 2026Exact Annex II–VI evidence
Annex IIIentry 186
Open full regulatory recordDIETHYLENE GLYCOL
Product scope: As traces in ingredients
Maximum concentration: 0.1%
Chemical identity and properties
- IUPAC name
- 2-(2-hydroxyethoxy)ethanol
- Molecular formula
- C4H10O3
- Molecular weight
- 106.12 g/mol
- Exact mass
- 106.062994177 Da
- XLogP3
- -1.3
- Topological polar surface area
- 49.7 Ų
- Hydrogen-bond donors
- 2
- Hydrogen-bond acceptors
- 3
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
2,2'-Oxydiethanol2,2'-OxybisethanolDiglycolDiethylenglykolDigolBis(2-hydroxyethyl) ether2-Hydroxyethyl etherGlycol ether
16 more reported names
Ethanol, 2,2'-oxybis-Ethylene diglycolDigenosDicolBrecolane ndgDeactivator EDissolvant APV2,2'-Oxyethanol1,5-Dihydroxy-3-oxapentane3-Oxapentane-1,5-diolDihydroxydiethyl etherTL4N3-Oxapentamethylene-1,5-diolBis(beta-hydroxyethyl) ether2,2'-Dihydroxydiethyl ether3-Oxa-1,5-pentanediol
External database identifiers
- ChEBI:CHEBI:46807
- ChEMBL:CHEMBL1235226
- EPA DTXSID:DTXSID8020462
- PubMed:36087010
- PubMed:35385781
- PubMed:25622337
- PubMed:23827505
- PubMed:22954530
- PubMed:22606114
- PubMed:22247651
- PubMed:22016655
- PubMed:21935381
- PubMed:21856646
- PubMed:21804082
- PubMed:21730503
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match8117
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: 444 °F (USCG, 1999) Source: CAMEO Chemicals
- Autoignition Temperature: 444 °F Source: Hazardous Substances Data Bank (HSDB)
- Autoignition Temperature: 229 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 473 °F at 760 mmHg (NTP, 1992) Source: CAMEO Chemicals
- Boiling Point: 245.8 °C Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 245 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Color/Form: Colorless syrupy liquid Source: Hazardous Substances Data Bank (HSDB)
- Density: 1.118 at 68 °F (USCG, 1999) - Denser than water; will sink Source: CAMEO Chemicals
- Density: 1.1197 g/cu cm at 15 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: Relative density (water = 1): 1.12 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Density: 1.12 @ 15°C Source: PAC Chemical Database, U.S. Department of Energy
- Flash Point: 290 °F (NTP, 1992) Source: CAMEO Chemicals
- Flash Point: 124 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Flash Point: 280 to 290 °F (open cup) /from table/ Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 124 °C c.c. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- LogP: -1.47 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: 14 °F (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: -10.4 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -6.5 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -10.4 °C Source: PAC Chemical Database, U.S. Department of Energy
- Odor: Practically odorless Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Diethylene glycol appears as a colorless liquid. Denser than water. Contact may slightly irritate skin, eyes and mucous membranes. May be slightly toxic by ingestion. Used to make other chemicals. Source: CAMEO Chemicals
- Physical Description: CBI; Liquid; Wet Solid; Liquid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Very hygroscopic, colorless liquid; [Hawley] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: ODOURLESS COLOURLESS VISCOUS HYGROSCOPIC LIQUID. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Refractive Index: Index of refraction = 1.4472 at 20 °C/D Source: Hazardous Substances Data Bank (HSDB)
- Solubility: greater than or equal to 100 mg/mL at 68 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: Immiscible with toluene, petroleum, linseed or castor oil Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in chloroform Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Soluble in ethanol, ethyl ether Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Miscible with alcohol, ether, acetone, ethylene glycol; practically insoluble in benzene, carbon tetrachloride Source: Hazardous Substances Data Bank (HSDB)
- Solubility: Solubility in water: miscible Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Vapor Pressure: less than 0.01 mmHg at 68 °F ; 0.01 mmHg at 86 °F (NTP, 1992) Source: CAMEO Chemicals
- Vapor Pressure: 0.0057 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: VP: 1 mm Hg at 91.8 °C Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: 5.7X10-3 mm Hg at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: Vapor pressure, Pa at 20 °C: 2.7 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Vapor Pressure: 0.0057 [mm Hg] @25 °C Source: PAC Chemical Database, U.S. Department of Energy
- Viscosity: 0.30 cP at 25 °C Source: Hazardous Substances Data Bank (HSDB)
- Exposure Routes: The substance can be absorbed into the body by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Apparatus (SCBA) shou Source: CAMEO Chemicals
- Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Warning Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 5754 reports by companies from 38 notifications to the ECHA C&L Inventory.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
- Precautionary Statement Codes: P203, P260, P264, P270, P280, P318, P319, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- Signal: Warning Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- GHS Hazard Statements: H302: Harmful if swallowed [Warning Acute toxicity, oral] Source: Hazardous Chemical Information System (HCIS), Safe Work Australia
- NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Fire Rating: 1 - Materials that must be preheated before ignition can occur. Materials require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
- Environmental Bioconcentration: An estimated BCF of 3 was calculated in fish for diethylene glycol(SRC), using an estimated log Kow of -1.5(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that diethylene glycol is expected to have very high mobility in soil(SRC). Volatilization of diethylene glycol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 2.0X10-9 atm-cu m/mole(SRC), using a fragment constant estimation method(3). Diethylene glycol is not expected to volatilize from dry soil surfaces(SRC) based upon a vapor pressure of 5.7X10-3 mm Hg at 25 °C(4). Diethylene glycol was readily biodegraded in a sandy loam(5) suggesting that biodegradation is an important environmental fate process in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1(SRC), determined from a structure estimation method(2), indicates that diethylene glycol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 2.0X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(6), an estimated BCF of 3(SRC), from an estimated log Kow of -1.5(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is low(SRC). Diethylene glycol was biodegraded partially from river water within 7 days at 20 °C, but under winter conditions of river flow and temperature (less than 8 °C) degradation was minimal(9). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), diethylene glycol, which has a vapor pressure of 5.7X10-3 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase diethylene glycol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 17 hrs(SRC), calculated from its rate constant of 3.0X10-11 cu cm/molecule-sec at 25 °C(3). Diethylene glycol degraded 5.5% by light at a wavelength greater than 290 nm over a period of 17 hours(4) and therefore may be susceptible to direct photolysis by sunlight(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Hydraulic fluids; Plasticizer; Stabilizing agent; Catalyst; Not Known or Reasonably Ascertainable; Corrosion inhibitor; Soil amendments (fertilizers); Adhesion/cohesion promoter; Intermediate; Solvent; Anti-adhesive/cohesive; Anti-freeze agent; Other; Freeze-thaw additive; Lubricating agent; Processing aids not otherwise specified; Monomers; Fuel agents; Heat transferring agent Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Fuel agents; Heat transferring agent; Processing aids not otherwise specified; Surfactant (surface active agent); Monomers; Wetting agent (non-aqueous); Other; CBI; Lubricating agent; Freeze-thaw additive; Solvent; Anti-freeze agent; Anti-adhesive/cohesive; Adhesion/cohesion promoter; Intermediate; Emulsifier; Catalyst; Corrosion inhibitor; Filler; Not Known or Reasonably Ascertainable; Hydraulic fluids; Dehydrating agent (desiccant) Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used as a humectant (tobacco, casein, synthetic sponges, composition corks, glues, gelatin, and paper products), a dehydrating agent (plasticizers, surfactants, and natural gas), a lubricating and finishing agent (wool, worsted, cotton, rayon, and silk), a solvent for vat dyes, an intermediate (triethylene glycol and diethylene glycol dinitrate), a petroleum extraction solvent, and a monomer (unsaturated polyester resins and polyols for polyurethane); Also used in lacquers, cosmetics, antifreeze solutions for sprinkler systems; water seals for gas tanks, brake fluids, lubricants, mold release agents, and inks; [HSDB] Used mainly to produce unsaturated polyester resins, polyols, and polyurethanes; [Reference #1] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Petroleum Production and Refining [Category: Industry]; Pulp and Paper Processing [Category: Industry]; Painting (Solvents) [Category: Paint]; Working with Glues and Adhesives [Category: Other]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: Production of polyurethane and unsaturated polyester resins, triethylene glycol; textile softener; petroleum solvent extraction; dehydration of natural gas, plasticizers, and surfactants; solvent for nitrocellulose and many dyes and oils; humectant for tobacco, casein, synthetic sponges, paper products; cork compositions, bookbinding adhesives, dyeing assistant, cosmetics, antifreeze solutions. Source: Hazardous Substances Data Bank (HSDB)
- Uses: In antifreeze soln for sprinkler systems; for water seals for gas tank; lubricating and finishing agent for wool, worsted, cotton, rayon and silk; solvent for vat dyes; in composition corks, glues, gelatin, casein, and pastes to prevent drying out. Source: Hazardous Substances Data Bank (HSDB)
- Uses: Diethylene glycol is used in gas conditioning and in the permanent antifreeze formulations; as a constituent of brake fluids, lubricants, mold release agents, and inks; as a softening agent for textiles; as a plasticizer for cork, adhesives, paper, packaging materials, and coatings; as an intermediate in the prodn of explosive diethylene glycol dinitrate; and as an intermediate in the production of certain resins, morpholine, and diethylene glycol esters and ethers. Source: Hazardous Substances Data Bank (HSDB)
- Uses: In lacquer industry and in cosmetics Source: Hazardous Substances Data Bank (HSDB)
- Uses: For more Uses (Complete) data for DIETHYLENE GLYCOL (9 total), please visit the HSDB record page. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
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Official source and scope
Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.
Open official Decision