Cyclohexanone
- IUPAC name
- cyclohexanone
- Molecular formula
- C6H10O
- Molecular weight
- 98.14 g/mol
- Exact mass
- 98.073164938 Da
- XLogP3
- 0.8
- Topological polar surface area
- 17.1 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 1
- Covalent units
- 1
- Defined stereocentres
- 0
Also known as
16 more reported names
External database identifiers
- ChEBI:CHEBI:17854
- ChEMBL:CHEMBL18850
- EPA DTXSID:DTXSID6020359
- PubMed:27633901
- PubMed:23125771
- PubMed:23094717
- PubMed:23072451
- PubMed:22952036
- PubMed:22952025
- PubMed:22871061
- PubMed:22853437
- PubMed:22828583
- PubMed:22795665
- PubMed:22750815
- PubMed:22712543
Evidence from additional scientific databases
NIH PubChem PUG-View
Attributed physical-property, hazard, environmental and use annotations.
- Autoignition Temperature: 788 °F (USCG, 1999) Source: CAMEO Chemicals
- Autoignition Temperature: 420 °C; 788 °F Source: Hazardous Substances Data Bank (HSDB)
- Autoignition Temperature: 420 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 312.1 °F at 760 mmHg (NTP, 1992) Source: CAMEO Chemicals
- Boiling Point: 155.4 °C Source: DrugBank
- Boiling Point: 155.6 °C @ 760 MM HG; 132.5 °C @ 400 MM HG; 110.3 °C @ 200 MM HG; 90.4 °C @ 100 MM HG; 77.5 °C @ 60 MM HG; 67.8 °C @ 40 MM HG; 52.5 °C @ 20 MM HG; 38.7 °C @ 10 MM HG; 26.4 °C @ 5 MM HG; 1.4 °C @ 1.0 MM HG Source: Hazardous Substances Data Bank (HSDB)
- Boiling Point: 154.00 to 156.00 °C. @ 760.00 mm Hg Source: Human Metabolome Database (HMDB)
- Boiling Point: 156 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Boiling Point: 154-156 °C Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Boiling Point: 312 °F Source: Occupational Safety and Health Administration (OSHA)
- Boiling Point: 155.43 °C @760 [mm Hg] Source: PAC Chemical Database, U.S. Department of Energy
- Boiling Point: 312 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- Color/Form: OILY LIQUID Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: WATER-WHITE TO PALE YELLOW LIQUID Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Water-white to pale-yellow liquid ... Source: Hazardous Substances Data Bank (HSDB)
- Density: 0.945 at 68 °F (USCG, 1999) - Less dense than water; will float Source: CAMEO Chemicals
- Density: 0.9421 @ 25 °C/4 °C; 0.9478 @ 20 °C/4 °C Source: Hazardous Substances Data Bank (HSDB)
- Density: Relative density (water = 1): 0.95 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Density: 0.947-0.950 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Density: 0.95 Source: Occupational Safety and Health Administration (OSHA)
- Density: 0.9421 @25 °C Source: PAC Chemical Database, U.S. Department of Energy
- Density: 0.95 Source: The National Institute for Occupational Safety and Health (NIOSH)
- pKa: 11.3 Source: DrugBank
- Flash Point: 111 °F (NTP, 1992) Source: CAMEO Chemicals
- Flash Point: 44 °C Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Flash Point: 111 °F (44 °C) (closed cup) Source: Hazardous Substances Data Bank (HSDB)
- Flash Point: 44 °C c.c. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Flash Point: 146 °F Source: Occupational Safety and Health Administration (OSHA)
- Flash Point: 111 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- LogP: 0.81 Source: DrugBank
- LogP: Log Kow= 0.81 Source: Hazardous Substances Data Bank (HSDB)
- LogP: 0.81 Source: Human Metabolome Database (HMDB)
- LogP: 0.81 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: 3 °F (NTP, 1992) Source: CAMEO Chemicals
- Melting Point: -31 °C Source: DrugBank
- Melting Point: -31 °C Source: Hazardous Substances Data Bank (HSDB)
- Melting Point: -31 °C Source: Human Metabolome Database (HMDB)
- Melting Point: -32.1 °C Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Melting Point: -49 °F Source: Occupational Safety and Health Administration (OSHA)
- Melting Point: -27.9 °C Source: PAC Chemical Database, U.S. Department of Energy
- Melting Point: -49 °F Source: The National Institute for Occupational Safety and Health (NIOSH)
- Odor: ODOR REMINISCENT OF PEPPERMINT & ACETONE Source: Hazardous Substances Data Bank (HSDB)
- Odor: ... Peppermint- or acetone-like odor. Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Cyclohexanone appears as a colorless to pale yellow liquid with a pleasant odor. Less dense than water. Flash point 111 °F. Vapors heavier than air. Used to make nylon, as a chemical reaction medium, and as a solvent. Source: CAMEO Chemicals
- Physical Description: Liquid; CBI Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Water-white to pale-yellow liquid with a peppermint- or acetone-like odor; [NIOSH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Physical Description: Liquid Source: Human Metabolome Database (HMDB)
- Physical Description: COLOURLESS OILY LIQUID WITH CHARACTERISTIC ODOUR. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Physical Description: Oily liquid; odour reminiscent of peppermint and acetone Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Physical Description: Water-white to pale-yellow liquid with a peppermint- or acetone-like odor. Source: Occupational Safety and Health Administration (OSHA)
- Physical Description: Water-white to pale-yellow liquid with a peppermint- or acetone-like odor. Source: The National Institute for Occupational Safety and Health (NIOSH)
- Refractive Index: INDEX OF REFRACTION: 1.4507 @ 20 °C Source: Hazardous Substances Data Bank (HSDB)
- Refractive Index: 1.447-1.453 Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: 50 to 100 mg/mL at 64 °F (NTP, 1992) Source: CAMEO Chemicals
- Solubility: 25000 mg/L (at 25 °C) Source: DrugBank
- Solubility: SOLUBILITY OF WATER IN CYCLOHEXANONE: 87 G/L AT 20 °C. Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 150 G/L IN WATER @ 10 °C; 50 G/L IN WATER @ 30 °C Source: Hazardous Substances Data Bank (HSDB)
- Solubility: SOL IN ACETONE; ETHYL ETHER; ETHANOL; WATER Source: Hazardous Substances Data Bank (HSDB)
- Solubility: SOLUBLE IN ALCOHOL, ETHER, AND OTHER COMMON ORGANIC SOLVENTS Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 25 mg/mL at 25 °C Source: Human Metabolome Database (HMDB)
- Solubility: Solubility in water, g/100ml at 20 °C: 8.7 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Solubility: water; ether; chloroform; organic solvents Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: Miscible at room temperature (in ethanol) Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
- Solubility: 15% Source: The National Institute for Occupational Safety and Health (NIOSH)
- Vapor Pressure: 5.2 mmHg at 77 °F ; 10 mmHg at 101.7 °F (NTP, 1992) Source: CAMEO Chemicals
- Vapor Pressure: 5.0 [mmHg] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Vapor Pressure: 5 mm Hg at 26.4 °C Source: Hazardous Substances Data Bank (HSDB)
- Vapor Pressure: Vapor pressure, Pa at 20 °C: 500 Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Vapor Pressure: 5 mmHg Source: Occupational Safety and Health Administration (OSHA)
- Vapor Pressure: 7.5 [mm Hg] @36 °C Source: PAC Chemical Database, U.S. Department of Energy
- Vapor Pressure: 5 mmHg Source: The National Institute for Occupational Safety and Health (NIOSH)
- Viscosity: 2.2 mPa.s (=cP) @ 25 °C Source: Hazardous Substances Data Bank (HSDB)
- IARC Carcinogenic Agent: Cyclohexanone Source: International Agency for Research on Cancer (IARC)
- IARC Carcinogenic Classes: Group 3: Not classifiable as to its carcinogenicity to humans Source: International Agency for Research on Cancer (IARC)
- IARC Monographs: Volume 47: (1989) Some Organic Solvents, Resin Monomers and Related Compounds, Pigments and Occupational Exposures in Paint Manufacture and Painting; Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Part 1, Part 2, Part 3) Source: International Agency for Research on Cancer (IARC)
- Publication Year: 1999 Source: International Agency for Research on Cancer (IARC)
- Evaluation Year: 1998 Source: International Agency for Research on Cancer (IARC)
- Exposure Routes: The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. Source: ILO-WHO International Chemical Safety Cards (ICSCs)
- Exposure Routes: inhalation, skin absorption, ingestion, skin and/or eye contact Source: The National Institute for Occupational Safety and Health (NIOSH)
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. IMMEDIATELY call a hospital or poison control center even if no symptoms (such as redness or irritation) develop. IMMEDIATELY transport the victim to a hospital for treatment after washing the affected areas.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whene Source: CAMEO Chemicals
- ERG2024, Guide 127 (Cyclohexanone): General First Aid:; · Call 911 or emergency medical service.; · Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.; · Move victim to fresh air if it can be done safely.; · Administer oxygen if breathing is difficult.; · If victim is not breathing:; -- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.; -- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).; -- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.; · Remove and isolate contaminated clothing and shoes.; · For minor skin contact, avoid spreading material on unaffected skin.; · In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.; · For severe burns, immediate medical attention is required.; · Effects of exposure (inhalation, ingestion, Source: Emergency Response Guidebook (ERG)
- First Aid: (General first aid procedures); Eye: Irrigate immediately - If this chemical contacts the eyes, immediately wash (irrigate) the eyes with large amounts of water, occasionally lifting the lower and upper lids. Get medical attention immediately.; Skin: Water flush promptly - If this chemical contacts the skin, flush the contaminated skin with water promptly. If this chemical penetrates the clothing, immediately remove the clothing and flush the skin with water promptly. If irritation persists after washing, get medical attention.; Breathing: Respiratory support; Swallow: Medical attention immediately - If this chemical has been swallowed, get medical attention immediately. Source: The National Institute for Occupational Safety and Health (NIOSH)
- Signal: Warning Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H332: Harmful if inhaled [Warning Acute toxicity, inhalation] Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P271, P280, P303+P361+P353, P304+P340, P317, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: Regulation (EC) No 1272/2008 of the European Parliament and of the Council
- Signal: Danger Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: H226 (> 99.9%): Flammable liquid and vapor [Warning Flammable liquids]; H302 (32.1%): Harmful if swallowed [Warning Acute toxicity, oral]; H312 (31.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]; H315 (17.9%): Causes skin irritation [Warning Skin corrosion/irritation]; H318 (31.6%): Causes serious eye damage [Danger Serious eye damage/eye irritation]; H332 (99.6%): Harmful if inhaled [Warning Acute toxicity, inhalation] Source: European Chemicals Agency (ECHA)
- Precautionary Statement Codes: P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P354+P338, P317, P321, P330, P332+P317, P362+P364, P370+P378, P403+P235, and P501 (click each P-code to see the statement) Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 4081 reports by companies from 32 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Signal: Danger Source: NITE-CMC
- GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H317: May cause an allergic skin reaction [Warning Sensitization, Skin]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure] Source: NITE-CMC
- Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P272, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P316, P318, P319, P321, P330, P332+P317, P333+P317, P337+P317, P361+P364, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- GHS Hazard Statements: H226: Flammable liquid and vapor [Warning Flammable liquids]; H302: Harmful if swallowed [Warning Acute toxicity, oral]; H305: May be harmful if swallowed and enters airways [Warning Aspiration hazard]; H311: Toxic in contact with skin [Danger Acute toxicity, dermal]; H315: Causes skin irritation [Warning Skin corrosion/irritation]; H319: Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H331: Toxic if inhaled [Danger Acute toxicity, inhalation]; H335: May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]; H336: May cause drowsiness or dizziness [Warning Specific target organ toxicity, single exposure; Narcotic effects]; H341: Suspected of causing genetic defects [Warning Germ cell mutagenicity]; H351: Suspected of causing cancer [Warning Carcinogenicity]; H361: Suspected of damaging fertility or the unborn child [Warning Reproductive toxicity]; H370: Causes damage to organs [Danger Specific target organ toxicity, single exposure]; H371: May cause damage to organs [Warning Specific target organ toxicity, single exposure]; H372: Causes damage to organs through prolonged or repeated exposure [ Source: NITE-CMC
- Precautionary Statement Codes: P203, P210, P233, P240, P241, P242, P243, P260, P261, P262, P264, P264+P265, P270, P271, P280, P301+P316, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P308+P316, P316, P318, P319, P321, P330, P331, P332+P317, P337+P317, P361+P364, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) Source: NITE-CMC
- NFPA Health Rating: 1 - Materials that, under emergency conditions, can cause significant irritation. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Fire Rating: 2 - Materials that must be moderately heated or exposed to relatively high ambient temperatures before ignition can occur. Materials would not under normal conditions form hazardous atmospheres with air, but under high ambient temperatures or under moderate heating could release vapor in sufficient quantities to produce hazardous atmospheres with air. Source: Hazardous Substances Data Bank (HSDB)
- NFPA Instability Rating: 0 - Materials that in themselves are normally stable, even under fire conditions. Source: Hazardous Substances Data Bank (HSDB)
- Target Organs: Eyes, skin, respiratory system, central nervous system, liver, kidneys Source: The National Institute for Occupational Safety and Health (NIOSH)
- Environmental Bioconcentration: The bioconcentration factor (BCF) for cyclohexanone can be estimated to be 2.4 based on the log Kow of 0.81(1) and a recommended regression equation(2). This BCF indicates that cyclohexanone will not bioconcentrate in aquatic organisms(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Bioconcentration: Based on a water solubility of 23,000 mg/l at 20 °C(1) and a log Kow of 0.81(2), the log BCF for cyclohexanone has been estimated to be 0.14 and 0.39, respectively, from recommended regression equations(1,3,SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Cyclohexanone is estimated to be highly mobile in soil(1,3,SRC). In view of its moderate vapor pressure(2) and low adsorption to soil(3), it would be expected to volatilize from surface soil. Although data are lacking, it may also undergo direct photolysis on the soil surface(4). Cyclohexanone is readily biodegradable according to aerobic screening tests(5-12) and therefore would be expected to biodegrade in soil(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: If released in water, cyclohexanone would be slowly lost by volatilization. Its estimated half-lives in a model river and model lake are 4.1 and 33 days, respectively(1,2). Cyclohexanone is readily biodegradable according to aerobic screening tests(6) and in a die-away test performed using microorganisms from river water(3) and therefore, may be expected to biodegrade in natural waters. Adsorption to sediment(2,4) and bioconcentration(2,5) in aquatic organisms should be minimal(2) based upon its high water solubility(4) and low octanol/water partition coefficient(5). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: In the atmosphere, cyclohexanone will degrade by reacting with photochemically-produced hydroxyl radicals. Its estimated half-life resulting from this reaction is 1.3 days(1,2). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Intermediate; Not Known or Reasonably Ascertainable; Cleaning agent; Other; Solvent Source: EPA Chemical Data Reporting (CDR)
- Industry Uses: Cleaning agent; Plasticizer; Corrosion inhibitor; Diluent; Not Known or Reasonably Ascertainable; Intermediate; Dispersing agent; Solvent; Binder; Monomers; Fuel Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Has many uses as an industrial solvent; used as a paint remover and in printing inks; [ACGIH] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Painting (Solvents) [Category: Paint]; Working with Glues and Adhesives [Category: Other]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: The active ingredient is no longer contained in any registered pesticide products ... "cancelled." Source: Hazardous Substances Data Bank (HSDB)
- Uses: SOLVENT FOR CELLULOSE ACETATE, NITROCELLULOSE, WAXES, FAT, VINYL RESINS, CRUDE RUBBER, NATURAL RESINS, SHELLAC, DDT; IN PREPN OF CYCLOHEXANONE RESINS. 2,4-DINITROPHENYLHYDRAZONE DERIV AS STANDARD IN ELEMENTAL ANALYSIS. Source: Hazardous Substances Data Bank (HSDB)
- Uses: METAL DEGREASING SOLVENT FOR LACQUERS, RESINS AND INSECTICIDES Source: Hazardous Substances Data Bank (HSDB)
- Uses: SOLVENT FOR PVC POLYMERS & COPOLYMERS, LACQUERS; SPOT REMOVER AND DEGREASER FOR LEATHER Source: Hazardous Substances Data Bank (HSDB)
- Uses: Over 96% of all cyclohexanone produced is oxidized to adipic acid (for the manufacture of nylon 66) or converted to caprolactam (for the manufacture of nylon 6). Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.