Official EU label nameGlossary entry 656

ACETYL HEXAPEPTIDE-8

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 0 of 13 indexed market datasets: 0 country records and 0 EU Annex records. Every result and evidence gap is listed below.

0 markets with evidence

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Evidence gaps

Resolved identifiers

Resolved substance identity

CAS:616204-22-9

Ingredient index records:

ACETYL HEXAPEPTIDE-8

Cosmetic functions: HUMECTANT, SKIN CONDITIONING

Acetyl hexapeptide-8 is the synthetic peptide consisting of arginine, methionine, and acetylated glutamic acid residues

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1 matched or reported name

ACETYL HEXAPEPTIDE-8

Official name structure and source evidence

This section separates facts supplied by external records from structure derived only from the exact official label wording.

Structured interpretation of the official EU INCI label

Matchedlabel-analysis-v1 · EU 2025/1175

The official label identifies a peptide- or protein-related cosmetic material.

Identity type inferred from wording: peptide_or_protein

This structure is derived only from the official label wording. It does not establish composition, concentration, chemical equivalence, safety or regulatory permission.

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Regulatory evidence across markets

None of the 13 markets tracked here holds an imported rule under the name ACETYL HEXAPEPTIDE-8.

That is a statement about this inventory, not about the law: no imported rule is not evidence that a substance is permitted. A rule may exist under a different name, under a CAS or EC number this glossary entry does not carry, or in a dataset not yet imported.

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Chemical identity and properties

PubChem 2D chemical structure for CAS 616204-22-9

CAS 616204-22-9PubChem CID 71587772

Acetyl hexapeptide-3

Argireline has been used in trials studying the treatment of wrinkles. — DrugBank

IUPAC name: (4S)-4-acetamido-5-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]hex-5-enoic acid

Molecular formula: C35H62N14O11S
Molecular weight: 887.0 g/mol
Exact mass: 886.44432002 Da
XLogP3: -5.2
Topological polar surface area: 472.0 Å²
Hydrogen-bond donors: 14
Hydrogen-bond acceptors: 15
Covalent units: 1
Defined stereocentres: 6

Also known as

Acetyl Hexapeptide-8Argireline NPHexapeptide 3L4EL31FWILAcetyl hexapeptide 3Acetyl-glu-glu-met-gln-arg-arg-amidel-Argininamide, N-acetyl-l-alpha-glutamyl-l-alpha-glutamyl-l-methionyl-l-glutaminyll-l-arginyl-RefChem:552452

10 more reported names

ACETYL HEXAPEPTIDE-8 [INCI]ACETYL HEXAPEPTIDE-3 [WHO-DD]801-648-4926-238-3L-ARGININAMIDE, N-ACETYL-L-.ALPHA.-GLUTAMYL-L-.ALPHA.-GLUTAMYL-L-METHIONYL-L-GLUTAMINYLL-L-ARGINYL-ARGIRELINEUNII-L4EL31FWILBotulinoidAcetyl Hexapeptide-8 (Powder)Acetyl Hexapeptide-8 (Liquid)

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External database identifiers

EPA DTXSID:DTXSID201021291

Retrieved from NIH PubChem on 2026-09-02 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal US EPA CompTox CTX APIs

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Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

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