Official EU label nameGlossary entry 6397
CI 42045
This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.
Global evidence snapshot
The resolved identity has matching regulatory evidence in 1 of 13 indexed market datasets: 1 country records and 0 EU Annex records. Every result and evidence gap is listed below.
Markets checked
13
Markets with evidence
1
Evidence gaps
12
Resolved identifiers
2
A missing local match is not permission, approval or proof of safety. It means no strong identity match was resolved in that indexed dataset.
Resolved substance identity
CAS:129-17-9
EC:204-934-1
Ingredient index records:
CI 42045
Cosmetic functions: COLORANT
Hydrogen [4-[4-(diethylamino)-2',4'-disulphonatobenzhydrylidene]cyclohexa-2,5-dien-1-ylidene]diethylammonium, sodium salt
Inventory restriction note: IV/59 (CI 42045) II/1355 (Acid Blue 1; CI 42045: when used as a substance in hair dye products)
2 matched or reported names
CI 42045Hidróxido de N-(4-((4-(dietilamino)fenil)(2,4-dissulfofe nil)metileno)-2,5-ciclohexadien-1-ilideno )- N-etil-etanamínio, seu sal interno e seu sal de sódio (CI 42045), quando usado como substância que entra na composição de corantes capilares
Regulatory evidence in all 13 markets
Open each matched record for its scope, concentration, conditions, warnings and official source version.
Swipe or scroll horizontally to see dataset coverage and next actions.
| Market | Result | Records | Dataset | Meaning / next action |
|---|---|---|---|---|
| European Union EU | No local match | 0 | Complete annex dataset Regulation (EC) 1223/2009 consolidated to 1 May 2026 | No annex match only means that these five annexes did not return a match; CosIng identity data and other EU obligations still need review. |
| Great Britain GB | No local match | 0 | Complete consolidated annex dataset GB retained Regulation 1223/2009 schedules, effective 15 August 2026 | No annex match is not approval and does not cover Northern Ireland, which follows the applicable EU framework. |
| Canada CA | No local match | 0 | Complete Hotlist snapshot Health Canada Cosmetic Ingredient Hotlist, 13 August 2025 | The Hotlist is an administrative compliance tool, not an exhaustive safety approval list. |
| New Zealand NZ | No local match | 0 | Complete schedules dataset Cosmetic Products Group Standard schedules effective 1 January 2026 | The searchable spreadsheet is an aid; the legal Group Standard and incorporated notices remain authoritative. |
| ASEAN ASEAN | No local match | 0 | Complete regional annex dataset ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026 | Regional annex coverage does not replace member-state implementation dates, notifications or national deviations. |
| China CN | No local match | 0 | Complete prohibited catalogues plus official-source workflow NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025 | IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately. |
| Japan JP | No local match | 0 | Complete Standards appendices dataset MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot | The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion. |
| South Korea KR | No local match | 0 | Complete current appendix dataset MFDS Notice 2026-19, effective 18 March 2026 | Korean source wording is canonical and other positive lists/notices may still apply to the formulation. |
| United States US | No local match | 0 | Complete enumerated federal ingredient rules eCFR Title 21 issue date 27 August 2026 | FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety. |
| Australia AU | No local match | 0 | Complete cosmetic-relevant Poisons Standard subset plus official workflow Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026 | An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction. |
| Brazil BR | Prohibited | 1Open record 1 | Complete prohibited dataset plus current restricted-list workflow ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026 | Review every linked record and exact conditions. |
| India IN | No local match | 0 | Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4 Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022) | The standards are separate controlled publications; absence from a locally indexed excerpt is not permission. |
| Saudi Arabia SA | No local match | 0 | Complete official list index SFDA live prohibited/restricted lists, snapshot 30 August 2026 | No list match is not permission; Gulf/SFDA product, claim, notification and technical requirements still apply. |
No market rows match this filter.
Matching market records and conditions
Chemical identity and properties
- IUPAC name
- sodium 4-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]benzene-1,3-disulfonate
- Molecular formula
- C27H31N2NaO6S2
- Molecular weight
- 566.7 g/mol
- Exact mass
- 566.15212334 Da
- Topological polar surface area
- 137.0 Ų
- Hydrogen-bond donors
- 0
- Hydrogen-bond acceptors
- 7
- Covalent units
- 2
- Defined stereocentres
- 0
Also known as
Patent Blue VFBlue VRSAcid Blue VHexacol Blue VRSSulphanblauDisulphen BlauDisulphine VNAlphazurine 2G
16 more reported names
Hidacid Blue VLeather Blue GAmacid Blue VCarmine Blue VFCarmin Blue VSFenazo Blue XFPatent Blue VSXylene Blue VSC.I. Acid Blue 1, sodium saltC.I. Food Blue 3Erioglaucine SupraHexaco Blue VRSKiton Pure Blue V FQSodium Blue VRSBrilliant Blue GSDisulfine Blue VN
External database identifiers
- ChEBI:CHEBI:34906
- ChEMBL:CHEMBL1731183
- EPA DTXSID:DTXSID3026065
Evidence from additional scientific databases
NIH PubChem PUG-View
Exact identifier match8507
Attributed physical-property, hazard, environmental and use annotations.
- Color/Form: VIOLET POWDER Source: Hazardous Substances Data Bank (HSDB)
- Color/Form: Dark bluish-green powder Source: Hazardous Substances Data Bank (HSDB)
- Physical Description: Sulfan blue is a dark greenish-black powder. (NTP, 1992) Source: CAMEO Chemicals
- Physical Description: Liquid; Wet Solid Source: EPA Chemical Data Reporting (CDR)
- Physical Description: Violet or dark bluish-green solid; [HSDB] Violet powder; [MSDSonline] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Solubility: Soluble (>=10 mg/ml at 70 °F) (NTP, 1992) Source: CAMEO Chemicals
- Solubility: ONE G DISSOLVES IN 20 ML WATER @ 20 °C; PARTLY SOL IN ALCOHOL Source: Hazardous Substances Data Bank (HSDB)
- Solubility: 30 mg/ml in water; 30 mg/ml in 2-methoxyethanol; 7 mg/ml in ethanol Source: Hazardous Substances Data Bank (HSDB)
- IARC Carcinogenic Agent: Blue VRS Source: International Agency for Research on Cancer (IARC)
- IARC Carcinogenic Classes: Group 3: Not classifiable as to its carcinogenicity to humans Source: International Agency for Research on Cancer (IARC)
- IARC Monographs: Volume 16: (1978) Some Aromatic Amines and Related Nitro Compounds – Hair Dyes, Colouring Agents and Miscellaneous Industrial Chemicals; Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) Source: International Agency for Research on Cancer (IARC)
- Publication Year: 1987 Source: International Agency for Research on Cancer (IARC)
- Evaluation Year: 1987 Source: International Agency for Research on Cancer (IARC)
- First Aid: EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.; SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing. Gently wash all affected skin areas thoroughly with soap and water. If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.; INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air. IMMEDIATELY call a physician and be prepared to transport the victim to a hospital even if no symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop. Provide proper respiratory protection to rescuers entering an unknown atmosphere. Whenever possible, Self-Contained Breathing Ap Source: CAMEO Chemicals
- Note: This chemical does not meet GHS hazard criteria for 91.8% (2068 of 2253) of all reports. Source: European Chemicals Agency (ECHA)
- GHS Hazard Statements: Not Classified; Reported as not meeting GHS hazard criteria by 2068 of 2253 companies (only 8.2% companies provided GHS information). For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- ECHA C&L Notifications Summary: Aggregated GHS information provided per 2253 reports by companies from 7 notifications to the ECHA C&L Inventory.; Reported as not meeting GHS hazard criteria per 2068 of 2253 reports by companies.; There are 6 notifications provided by 185 of 2253 reports by companies with hazard statement code(s).; Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website. Source: European Chemicals Agency (ECHA)
- Environmental Bioconcentration: An estimated BCF value of 2 was calculated for C.I. Acid Blue 1(SRC), using a measured water solubility of 30,000 mg/l(1) and a recommended regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: TERRESTRIAL FATE: Based on a recommended classification scheme(1), an estimated Koc value of 15(SRC), determined from a measured water solubility(2) and a recommended regression-derived equation(3), indicates that C.I. Acid Blue 1 will have very high mobility in soil(SRC). Due to the ionic nature of C.I. Acid Blue 1, the retention of the dye by ion-exchange processes(4,SRC), particularly on clay surfaces, and adsorption at mineral surfaces such as geothite(5,SRC), may slow down or prevent leaching(SRC). As C.I. Acid Blue 1 is an ionic compound, volatilization of this compound will not be important from moist soil surfaces(4,SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: AQUATIC FATE: Based on a recommended classification scheme(1), an estimated Koc value of 15(SRC), determined from a measured water solubility(2) and a recommended regression-derived equation(1), indicates that C.I. Acid Blue 1 should not adsorb to suspended solids and sediment in water(SRC). However, due to the ionic nature of C.I. Acid Blue 1, the retention of the dye by ion-exchange processes(3,SRC), particularly on clay surfaces, and adsorption at mineral surfaces such as geothite(4,SRC), may lead to increased adsorption on some surfaces(SRC). As C.I. Acid Blue 1 is an ionic compound, volatilization from water surfaces is not expected(3,SRC). According to a classification scheme(5), an estimated BCF value of 2(1,SRC), from a measured water solubility(2), suggests that bioconcentration in aquatic organisms is low(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Environmental Fate: ATMOSPHERIC FATE: The ionic state of C.I. Acid Blue 1 makes this compound essentially non-volatile(1,SRC); therefore, this compound should exist in the particulate phase in the ambient atmosphere. Particulate-phase C.I. Acid Blue 1 may be physically removed from the air, mainly by wet deposition(SRC). Source: Hazardous Substances Data Bank (HSDB)
- Consumer Uses: Not Known or Reasonably Ascertainable Source: EPA Chemical Data Reporting (CDR)
- Sources/Uses: Used as dye (medicinal products, wool, silk, leather, jute, paper, phenol-formaldehyde resins, milled soaps, inks, methylated spirit wash, casein, and lymphography) and biological stain; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Restricted Notes: Formerly used as a food dye (not currently permitted for use in food in the US, Japan, or EU, but is reportedly still used in some countries); Accepted for use in cosmetics not in contact with mucous membranes; [HSDB] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Industrial Processes with risk of exposure: Pulp and Paper Processing [Category: Industry]; Leather Tanning and Processing [Category: Industry]; Textiles (Printing, Dyeing, or Finishing) [Category: Industry] Source: Haz-Map, Information on Hazardous Chemicals and Occupational Diseases
- Uses: COLORING MEDICINAL PRODUCTS Source: Hazardous Substances Data Bank (HSDB)
- Uses: USED TO DYE WOOL, SILK, LEATHER, JUTE; TO STAIN PAPER, TO COLOR PHENOL-FORMALDEHYDE RESINS, MILLED SOAPS; TO COLOR INKS & METHYLATED SPIRIT WASH, MASS COLORATION OF CASEIN; AS A BIOLOGICAL STAIN; HEAVY METAL SALTS OF THE FREE ACID ARE USED AS PIGMENTS; ALUMINUM SALTS USED TO COLOR PHARMACEUTICALS Source: Hazardous Substances Data Bank (HSDB)
- Uses: FOOD DYE (REPORTED NON-U.S. USE) Source: Hazardous Substances Data Bank (HSDB)
- Uses: Used to dye wool directly and silk from either a sulfuric acid or acetic acid bath. It dyes fully chromed leather a bright blue, prints wool and silk directly. Source: Hazardous Substances Data Bank (HSDB)
Mapped by: Existing checksum-valid CAS to unique PubChem CID match. Retrieved: 2026-08-31. Open source record
Scientific classifications and hazard annotations provide context and do not replace the market-specific regulatory decision shown above.
Additional source coverage and match status
| Source | Result | Checked |
|---|---|---|
| NIH PubChem PUG-View | Exact match | 2026-08-31 |
A recorded no-match is useful evidence that the source was checked; it is not a claim that the substance does not exist elsewhere.
Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.
Additional authoritative substance research
These source-specific lookups can add hazard, toxicology, identity and assessment context. A link is a research route, not a claim that the source contains an exact record.
Cosmetic Ingredient Review safety assessments
Expert Panel conclusions, assessed ingredient groups, use conditions, dates and report documents
Independent expert review considered by FDA; not a government approval or binding market rule
Research this identityFDA Global Substance Registration System
UNII identifiers, preferred names, substance types, codes and public substance relationships
Identity registry only; UNII availability does not imply FDA review or approval
Research this identityILO/WHO International Chemical Safety Cards
Hazards, symptoms, first aid, storage, incompatibilities and physical properties for covered chemicals
International occupational chemical-safety reference; not cosmetic-use approval
Research this identityJapan NITE-CHRIP
Chemical identity, Japanese and foreign legal lists, GHS hazards and exposure-related information
Chemical-management evidence; cosmetic status remains governed by the applicable MHLW standard and market rules
Research this identityNIOSH Pocket Guide to Chemical Hazards
REL, PEL, IDLH, properties, exposure routes, symptoms, target organs, first aid and measurement methods for covered workplace chemicals
US occupational-health guidance and limits; not a cosmetic ingredient decision
Research this identityOECD eChemPortal
Gateway to authority-owned physical-property, fate, ecotoxicity, toxicity, exposure and GHS records
Discovery gateway; each linked authority remains responsible for its data
Research this identityUS EPA CompTox CTX APIs
DTXSID identity, experimental and predicted properties, toxicity, bioactivity, exposure and environmental data
Scientific and computational evidence; predictions must remain labelled and do not determine cosmetic legality
Research this identityContinue the compliance check
1. Confirm identity
Match the supplier specification, CAS/EC identifiers and composition to this official label name. Similar wording is not proof of chemical equivalence.
2. Review restrictions
Check every exact Annex record shown above, plus CMR, nanomaterial, SCCS and later-amendment requirements that may apply.
3. Verify the formula
Evaluate concentration, product type, purity, warnings, claims and each target market before making a compliance decision.
Official source and scope
Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.
Open official Decision