Official EU label nameGlossary entry 343

4-NITRO-O-PHENYLENEDIAMINE

This record confirms an official common ingredient name for EU cosmetic product labelling. It does not by itself confirm that the substance is permitted, unrestricted or safe.

Global evidence snapshot

The resolved identity has matching regulatory evidence in 7 of 13 indexed market datasets: 7 country records and 1 EU Annex records. Every result and evidence gap is listed below.

7 markets with evidence

Markets checked

Markets with evidence

Evidence gaps

Resolved identifiers

Resolved substance identity

CAS:99-56-9

EC:202-766-3

Ingredient index records:

4-NITRO-O-PHENYLENEDIAMINE

Cosmetic functions: HAIR DYEING

4-nitro-o-phenylenediamine (CI 76020)

Inventory restriction note: Annex III/240

Open full local profile

8 matched or reported names

4-NITRO-O-PHENYLENEDIAMINE4-Nitro-o-Phenylenediamine4-Nitro-1,2-phenylenediamine4-Nitro-o-phenylenediamine (4-nitro-1,2-phenylenediamine)4-Nitro-1,2-phenylenediamine 4-Nitro-o-Phenylenediamine CAS No 99-56-9p-니트로-o-페닐렌디아민1)p-니트로-o-페닐렌디아민4-Nitro-1,2-phenylenediam- ine 4-Nitro-o-Phenylene diamine (CAS No. 99-56-9)

Regulatory evidence in all 13 markets

Open each matched record for its scope, concentration, conditions, warnings and official source version.

Show rows

Swipe or scroll horizontally to see dataset coverage and next actions.

Market	Result	Records	Dataset	Meaning / next action
European Union EU	Restricted	1Open record 1	Complete annex dataset Regulation (EC) 1223/2009 consolidated to 1 May 2026	Review every linked record and exact conditions.
Great Britain GB	Restricted	1Open record 1	Complete consolidated annex dataset GB retained Regulation 1223/2009 schedules, effective 15 August 2026	Review every linked record and exact conditions.
Canada CA	No local match	0	Complete Hotlist snapshot Health Canada Cosmetic Ingredient Hotlist, 13 August 2025	The Hotlist is an administrative compliance tool, not an exhaustive safety approval list.
New Zealand NZ	Restricted	1Open record 1	Complete schedules dataset Cosmetic Products Group Standard schedules effective 1 January 2026	Review every linked record and exact conditions.
ASEAN ASEAN	Restricted	1Open record 1	Complete regional annex dataset ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026	Review every linked record and exact conditions.
China CN	No local match	0	Complete prohibited catalogues plus official-source workflow NMPA 2021 banned catalogues plus dynamic IECIC List I/List II system current since 2025	IECIC listing is not blanket approval; absence may require the new cosmetic ingredient route, and restrictions are checked separately.
Japan JP	No local match	0	Complete Standards appendices dataset MHLW Standards for Cosmetics official English source and Japanese amendments checked for the imported snapshot	The Japanese text and subsequent notices are canonical; no local match is not a product-compliance conclusion.
South Korea KR	Prohibited	2Open record 1 Open record 2	Complete current appendix dataset MFDS Notice 2026-19, effective 18 March 2026	Review every linked record and exact conditions.
United States US	No local match	0	Complete enumerated federal ingredient rules eCFR Title 21 issue date 27 August 2026	FDA has no general approved-cosmetic-ingredient catalogue; absence from these sections is not approval or proof of safety.
Australia AU	No local match	0	Complete cosmetic-relevant Poisons Standard subset plus official workflow Therapeutic Goods (Poisons Standard—June 2026) Instrument 2026	An AICIS Inventory match is not cosmetic approval; no Inventory match can indicate a new, exempted, reported or confidential introduction.
Brazil BR	No local match	0	Complete prohibited dataset plus current restricted-list workflow ANVISA RDC 1.029/2026 and RDC 1.030/2026, published 15 June 2026	RDC 1.030/2026 amends rather than replaces the prohibited baseline, and the second restricted-list revision was still under consultation in July 2026.
India IN	Restricted	1Open record 1	Complete current Part 2 dataset plus official workflow for Parts 1, 3 and 4 Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)	Review every linked record and exact conditions.
Saudi Arabia SA	Restricted	1Open record 1	Complete official list index SFDA live prohibited/restricted lists, snapshot 30 August 2026	Review every linked record and exact conditions.

Matching market records and conditions

European Union

Regulation (EC) 1223/2009 consolidated to 1 May 2026

4-Nitro-o-PhenylenediamineAnnex III

Hair dye substance in oxidative hair dye products

Great Britain

GB retained Regulation 1223/2009 schedules, effective 15 August 2026

4-Nitro-o-PhenylenediamineRestricted

Hair dye substance in oxidative hair dye products · After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0,5% · To be printed on the label: The mixing ratio. Read and follow instructions. This product is not intended for use on person…

GB Cosmetics Regulation, Annex III, entry 240 · 2026-08-15

New Zealand

Cosmetic Products Group Standard schedules effective 1 January 2026

4-Nitro-o-phenylenediamine (4-nitro-1,2-phenylenediamine)Restricted

Product scope: Hair dye substance in oxidative hair dye products · Maximum concentration: After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.5% · Warnings: The mixing ratio. ⚠Hair colourants can cause severe allergic reactions. Re…

Schedule 5, reference 240, source row 291 · effective-2026-01-01

ASEAN

ASEAN Cosmetic Directive annexes 2026-1, 22 June 2026

4-Nitro-1,2-phenylenediamine 4-Nitro-o-Phenylenediamine CAS No 99-56-9Restricted

Hair dye substance in oxidative hair dye products Use for dyeing eyelashes and eyebrows is not permitted. · After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.5% Indonesia only: After mixing under oxidative conditions the maximum …

ASEAN Annex III, reference 265 · 2026-1

South Korea

MFDS Notice 2026-19, effective 18 March 2026

p-니트로-o-페닐렌디아민1)Prohibited

화장품 안전기준 등에 관한 규정, 별표 1, record 1-75 · 2026-19

p-니트로-o-페닐렌디아민Restricted

산화염모제에 1.5% · 기타 제품에는 사용금지

화장품 안전기준 등에 관한 규정, 별표 2, record 2-173 · 2026-19

India

Cosmetics Rules 2020 plus current BIS IS 4707 parts (1:2020, 2:2025, 3:2025, 4:2022)

4-Nitro-1,2-phenylenediam- ine 4-Nitro-o-Phenylene diamine (CAS No. 99-56-9)Restricted

Field of application/use: Hair dye substance in oxidative hair dye products | Other limitations/requirements: After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0.5 percent | Label conditions/warnings: To be printed on the label: Th…

IS 4707 (Part 2):2025 Annex B, entry 243 · IS 4707 (Part 2):2025, fifth revision

Saudi Arabia

SFDA live prohibited/restricted lists, snapshot 30 August 2026

4-Nitro-1,2-phenylenediamineRestricted

SFDA restricted list, page 25, row 1 · live-snapshot-2026-08-30

Exact Annex II–VI evidence

Annex IIIentry 240

Open full regulatory record

4-Nitro-o-Phenylenediamine

Product scope: Hair dye substance in oxidative hair dye products

Restrictions: After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 0,5%

Warnings: To be printing on the label: Hair colorants can cause severe allergic reactions.

Chemical identity and properties

PubChem 2D chemical structure for CAS 99-56-9

CAS 99-56-9PubChem CID 5111791

4-Nitro-1,2-phenylenediamine

4-nitro-1,2-phenylenediamine is the primary amino compound that is 1,2-phenylenediamine (o-phenylenediamine) substituted at the 4- (para-) position by a nitro group. It is a C-nitro compound and a primary amino compound. It is functionally related to a 1,2-phenylenediamine. — ChEBI

IUPAC name: 4-nitrobenzene-1,2-diamine

Molecular formula: C6H7N3O2
Molecular weight: 153.14 g/mol
Exact mass: 153.053826475 Da
XLogP3: 0.9
Topological polar surface area: 97.9 Å²
Hydrogen-bond donors: 2
Hydrogen-bond acceptors: 4
Covalent units: 1
Defined stereocentres: 0

Also known as

4-Nitro-o-phenylenediamine1,2-Diamino-4-nitrobenzene2-Amino-4-nitroanilinep-Nitro-o-phenylenediamine1,2-Benzenediamine, 4-nitro-4-Nitro-1,2-diaminobenzene3,4-Diaminonitrobenzene4-Nitro-1,2-benzenediamine

16 more reported names

4-Nopd4-Nop4-N-o-Pda4NDBNCI-C03941O-PHENYLENEDIAMINE, 4-NITRO-5A9AX7Y0TTC.I. 76020CI 76020NSC-5378CHEBI:67116RefChem:855316202-766-34-Nitrophenylenediamine4-NO4-Nitro-o-phenylene-diamine

Open full PubChem record PubChem annotations 3D structure image

External database identifiers

ChEBI:CHEBI:67116
ChEMBL:CHEMBL433721
EPA DTXSID:DTXSID9020958
PubMed:26198647
PubMed:23105714
PubMed:22589761
PubMed:22490278
PubMed:22394515
PubMed:22367028
PubMed:22244140
PubMed:22129271
PubMed:22043215
PubMed:21787689
PubMed:21784121
PubMed:21777684

Retrieved from NIH PubChem on 2026-08-31 by checksum-valid CAS matching. Chemical properties do not replace the regulatory decision on this page.

Additional authoritative substance research

Each link searches that source for this identity. A link is a research route, not a claim that the source holds an exact record. What each source is, and its legal weight

Cosmetic Ingredient Review safety assessments FDA Global Substance Registration System ILO/WHO International Chemical Safety Cards Japan NITE-CHRIP NIOSH Pocket Guide to Chemical Hazards OECD eChemPortal US EPA CompTox CTX APIs

Take this record further

Screen in a formula Open standalone comparison

Official source and scope

Imported from Commission Implementing Decision (EU) 2025/1175 (dataset version EU 2025/1175). The glossary supplies common ingredient names for the ingredient list required by Article 19(1)(g); it is not an approval or safety list.

Open official Decision